Caesarean section and allergic manifestations: insufficient evidence of association found in population-based study of children aged 1 to 4 years
Article first published online: 2 AUG 2013
©2013 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd
Volume 102, Issue 10, pages 982–989, October 2013
How to Cite
Pyrhönen, K., Näyhä, S., Hiltunen, L. and Läärä, E. (2013), Caesarean section and allergic manifestations: insufficient evidence of association found in population-based study of children aged 1 to 4 years. Acta Paediatrica, 102: 982–989. doi: 10.1111/apa.12342
- Issue published online: 4 SEP 2013
- Article first published online: 2 AUG 2013
- Accepted manuscript online: 4 JUL 2013 11:01AM EST
- Manuscript Accepted: 1 JUL 2013
- Manuscript Revised: 28 MAY 2013
- Manuscript Received: 11 DEC 2012
- Caesarean section;
To provide evidence on the association between caesarean section and allergic manifestations in an unselected child population.
Research focused on all children aged from one to 4 years (N = 4779), born between April 2001 and March 2005 and living in the province of South Karelia, Finland. They were identified from the nationwide population register. Questionnaire data on 3181 participants were individually merged with allergy test results (skin prick tests, IgE antibodies and open food challenges) from all patient records.
Compared with vaginal delivery, the adjusted relative incidence of positive allergy tests (with 95% confidence intervals, CI) in children born by caesarean section was 1.14 (0.79, 1.65) for food, 1.16 (0.66, 2.05) for animals, 0.94 (0.46, 1.92) for pollen and 1.19 (0.87, 1.63) for any allergens. The corresponding adjusted prevalence odds ratios (with 95% CI) of physician-diagnosed allergic manifestations were 1.15 (0.80, 1.63) for food allergy, 0.90 (0.47, 1.59) for pollen allergy or hay fever, 1.00 (0.75, 1.31) for atopic eczema, 0.96 (0.53, 1.65) for asthma and 1.08 (0.85, 1.38) for any allergic manifestation.
Insufficient evidence was found in our population for any association between birth by caesarean section and allergic manifestations. Further evidence from unselected populations, with longer follow-up periods, is needed.