Monitoring Doppler patterns and clinical parameters may predict feeding tolerance in intrauterine growth-restricted infants
Article first published online: 3 OCT 2013
©2013 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd
Volume 102, Issue 11, pages e519–e523, November 2013
How to Cite
Bozzetti, V., Paterlini, G., Gazzolo, D., Van Bel, F., Visser, G. H., Roncaglia, N. and Tagliabue, P. E. (2013), Monitoring Doppler patterns and clinical parameters may predict feeding tolerance in intrauterine growth-restricted infants. Acta Paediatrica, 102: e519–e523. doi: 10.1111/apa.12380
- Issue published online: 3 OCT 2013
- Article first published online: 3 OCT 2013
- Accepted manuscript online: 8 AUG 2013 09:30AM EST
- Manuscript Accepted: 1 AUG 2013
- Manuscript Revised: 4 JUN 2013
- Manuscript Received: 21 FEB 2013
- Stella Cometa
- Let's Improve Perinatal Life Foundations
- Doppler velocimetry;
- Feeding tolerance;
- Full enteral feeding;
- Intrauterine growth restriction;
- Minimal enteral feeding
To detect predictors of feeding tolerance in intrauterine growth restriction (IUGR) infants with or without brain-sparing effect (BS).
We conducted a case–control study in 70 IUGR infants (35 IUGR with BS, matched for gestational age with 35 IUGR infants with no BS). BS was classified as pulsatility index (PI) ratio [umbilical artery (UAPI) to middle cerebral artery (MCAPI) (U/C ratio)] > 1. Clinical parameters of feeding tolerance – days to achieve full enteral feeding (FEF) – were compared between the IUGR with BS and IUGR without BS infants. Age at the start of minimal enteral feeding (MEF) was analysed.
Achievement of FEF was significantly shorter in IUGR infants without BS than in IUGR with BS. IUGR with BS started MEF later than IUGR without BS infants. Significant correlation of MEF and FEF with UA PI, U/C ratio and CRIB score was found. Multiple linear regression analysis showed significant correlations with CRIB score and caffeine administration (MEF only), and sepsis (FEF only) and U/C ratio (for both).
Impaired gut function can be early detected by monitoring Doppler patterns and clinical parameters.