Hospital- and community-associated methicillin-resistant Staphylococcus aureus: a 6-year surveillance study of invasive infections in Chinese children
Version of Record online: 10 SEP 2013
©2013 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd
Volume 102, Issue 11, pages 1081–1086, November 2013
How to Cite
Qiao, Y., Dong, F., Song, W., Wang, L., Yang, Y. and Shen, X. (2013), Hospital- and community-associated methicillin-resistant Staphylococcus aureus: a 6-year surveillance study of invasive infections in Chinese children. Acta Paediatrica, 102: 1081–1086. doi: 10.1111/apa.12386
- Issue online: 3 OCT 2013
- Version of Record online: 10 SEP 2013
- Accepted manuscript online: 12 AUG 2013 09:37AM EST
- Manuscript Accepted: 6 AUG 2013
- Manuscript Revised: 1 AUG 2013
- Manuscript Received: 27 MAR 2013
- National Natural Science Foundation of China. Grant Number: 81171648
- National Natural Science Foundation of China and the Research Grants Council of Hong Kong Joint Research Scheme. Grant Number: 81061160509
- Invasive infection;
- Methicillin-resistant Staphylococcus aureus
To investigate and compare the characteristics of invasive hospital-associated (HA) and community-associated (CA) methicillin-resistant Staphylococcus aureus (MRSA) infections in Chinese children.
Clinical data on 59 paediatric patients with invasive MRSA isolated from the normally sterile sites between 2006 and 2011 were obtained from the clinical MRSA surveillance database of Beijing Children's Hospital. The molecular characteristics of the invasive MRSA strains were then analysed.
Invasive MRSA infections rose from 0.89 per 10 000 admissions in 2006 to 3.75 in 2011, with a notable increase in invasive CA-MRSA infections from 0 to 2.43 over the same period. The median age of the CA patients (n = 29) was 0.33 years, compared with 1.17 years for the HA patients (n = 30). Multisite infection, severe pneumonia and empyema were found in 55.2%, 73.1% and 61.5% of CA children and in 30%, 32% and 24% of HA patients, respectively. ST59-MRSA-IVa accounted for 40.7% of all isolates and the Panton–Valentine leukocidin (PVL) gene carriage rate was significantly higher in patients with necrotizing pneumonia and osteoarthritis than in those with other diseases.
The incidence of paediatric invasive MRSA infection, particularly CA-MRSA infection, increased in Chinese children between 2006 and 2011. The invasive infections caused by CA-MRSA occurred more frequently in younger children with more severe pneumonia or empyema.