Serum fatty acid profile does not reflect seafood intake in adolescents with atopic eczema
Article first published online: 23 JUN 2014
© 2014 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
How to Cite
Barman, M., Jonsson, K., Sandin, A., Wold, A. E. and Sandberg, A.-S. (2014), Serum fatty acid profile does not reflect seafood intake in adolescents with atopic eczema. Acta Paediatrica. doi: 10.1111/apa.12690
- Article first published online: 23 JUN 2014
- Accepted manuscript online: 16 MAY 2014 07:47AM EST
- Manuscript Accepted: 13 MAY 2014
- Manuscript Revised: 23 APR 2014
- Manuscript Received: 19 FEB 2014
- Swedish Research Council. Grant Number: 521-213-3154
- Swedish Research Council for Environmental, Agricultural Sciences and Spatial Planning (FORMAS). Grant Number: 216-2009-752
- Västra Götaland Region
- Centre for Environment and Sustainability
- Research and Development Departments of the Jämtland and Norrbotten County Councils
- ThC Bergh Foundation
- Atopic eczema;
- Fatty acids;
- Polyunsaturated fatty acids
Long-chain polyunsaturated fatty acids (LCPUFAs) are immunomodulatory, but their role in allergy development is controversial. We investigated whether proportions of LCPUFAs in serum phospholipids were related to allergic diagnosis, seafood intake and LCPUFA proportions in cord blood.
Serum was obtained from 148 birth cohort children at 13 years of age. Forty had atopic eczema, 53 had respiratory allergy, and 55 were nonallergic. Proportions of LCPUFAs were determined in serum phospholipids; cord blood from 128 of the individuals was previously analysed. Seafood intake was estimated using questionnaires.
Allergic and nonallergic individuals did not differ significantly regarding individual LCPUFAs. However, arachidonic acid over docosahexaenoic acid (DHA) ratio was higher in allergic, compared with nonallergic, adolescents. In nonallergic individuals, LCPUFA proportions in cord serum and adolescent serum correlated weakly. In individuals with atopic eczema and respiratory allergy, these correlations were weak or absent. A moderate correlation between seafood intake and serum DHA was seen in nonallergic individuals and those with respiratory allergy, but not in those with atopic eczema.
Serum LCPUFA pattern was similar in allergic and nonallergic adolescents. Fatty acid metabolism may be altered in atopic eczema subjects, suggested by poor correlations between fatty acid intake and serum levels.