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Compartmentation of cAMP signalling in cardiomyocytes in health and disease

Authors

  • R. K. Perera,

    1. Emmy Noether Group of the DFG, Department of Cardiology and Pneumology, European Heart Research Insitute Göttingen, Georg August University Medical Center, University of Göttingen, Göttingen, Germany
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  • V. O. Nikolaev

    Corresponding author
    • Emmy Noether Group of the DFG, Department of Cardiology and Pneumology, European Heart Research Insitute Göttingen, Georg August University Medical Center, University of Göttingen, Göttingen, Germany
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Correspondence: V. O. Nikolaev, Emmy Noether Group of the DFG, Department of Cardiology and Pneumology, Georg August University Medical Center, Robert-Koch-Str. 40, D-37075 Göttingen, Germany.

E-mail: viacheslav.nikolaev@med.uni-goettingen.de

Abstract

3′,5′-cyclic adenosine monophosphate (cAMP) is a ubiquitous second messenger critically involved in the regulation of heart function. It has been shown to act in discrete subcellular signalling compartments formed by differentially localized receptors, phosphodiesterases and protein kinases. Cardiac diseases such as hypertrophy or heart failure are associated with structural and functional remodelling of these microdomains which leads to changes in cAMP compartmentation. In this review, we will discuss recent key findings which provided new insights into cAMP compartmentation in cardiomyocytes with a particular focus on its alterations in heart disease.

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