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Relative contribution of foetal and post-natal nutritional periods on feeding regulation in adult rats

Authors

  • A. Martin Agnoux,

    1. INRA, UMR1280, Physiologie des Adaptations Nutritionnelles, Nantes, France
    2. Université de Nantes, UMR 1280, Physiologie des Adaptations Nutritionnelles, Nantes, France
    3. IMAD, Institut des Maladies de l'Appareil Digestif, CRNH (Centre de Recherche en Nutrition Humaine), Nantes, France
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  • M. -C. Alexandre-Gouabau,

    1. INRA, UMR1280, Physiologie des Adaptations Nutritionnelles, Nantes, France
    2. Université de Nantes, UMR 1280, Physiologie des Adaptations Nutritionnelles, Nantes, France
    3. IMAD, Institut des Maladies de l'Appareil Digestif, CRNH (Centre de Recherche en Nutrition Humaine), Nantes, France
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  • G. Le Dréan,

    1. INRA, UMR1280, Physiologie des Adaptations Nutritionnelles, Nantes, France
    2. Université de Nantes, UMR 1280, Physiologie des Adaptations Nutritionnelles, Nantes, France
    3. IMAD, Institut des Maladies de l'Appareil Digestif, CRNH (Centre de Recherche en Nutrition Humaine), Nantes, France
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  • J. -P. Antignac,

    1. LUNAM université, Oniris, Laboratoire d'Etude des Résidus et Contaminants dans les Aliments (LABERCA), USC INRA 1329, Nantes, France
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  • P. Parnet

    Corresponding author
    1. INRA, UMR1280, Physiologie des Adaptations Nutritionnelles, Nantes, France
    2. Université de Nantes, UMR 1280, Physiologie des Adaptations Nutritionnelles, Nantes, France
    3. IMAD, Institut des Maladies de l'Appareil Digestif, CRNH (Centre de Recherche en Nutrition Humaine), Nantes, France
    • Correspondence: P. Parnet, UMR 1280 Physiologie des Adaptations Nutritionnelles, CHU Hotel Dieu HNB1, Place Alexis Ricordeau, F-44093 Nantes Cedex, France. E-mail: Patricia.parnet@univ-nantes.fr

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Abstract

Aim

The aim of this study was to assess the contribution of both foetal and/or post-natal nutritional periods on feeding regulation in adult rats.

Methods

Body weight gain, adipose tissue development, food preferences and feeding pattern under regular chow or Western diets were characterized on four experimental groups of rats: pups born from protein-restricted dams (R) and weaned by control (RC) or R dams (RR) and pups born from control dams weaned by C (CC) or R dams (CR).

Results

Rats born with intrauterine growth restriction (IUGR) and fed a Western diet at adulthood appeared predisposed to body weight gain and more fat accretion, whereas CR rats, despite their preference for high-fat diet and their hyperphagia for Western diet, did not show significant increase in fat tissue. Daytime food intakes, as well as their speed of ingestion, were found modified in RC and RR. Alterations in the hypothalamic appetite regulatory mechanisms were investigated through neuropeptide expression analysis. IUGR rats showed altered expression of key elements of leptin and NPY signalling, while CR rats exhibited lesser expression of enterostatin, MC4r and HT-1Br mRNA.

Conclusion

Altogether, these results indicate that peri-natal nutrition has different lasting effects on feeding pattern and hypothalamic appetite regulation, depending on the time window insult.

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