Frequent overexpression of ErbB – receptor family members in brain metastases of non-small cell lung cancer patients
Version of Record online: 12 JUN 2013
© 2013 APMIS. Published by John Wiley & Sons Ltd
Volume 121, Issue 12, pages 1144–1152, December 2013
How to Cite
Frequent overexpression of ErbB – receptor family members in brain metastases of non-small cell lung cancer patients. APMIS 2013; 121: 1144–1152., , , , , , , , , , , .
- Issue online: 25 NOV 2013
- Version of Record online: 12 JUN 2013
- Manuscript Accepted: 3 FEB 2013
- Manuscript Received: 19 DEC 2012
- Brain metastases;
- lung cancer;
- non-small cell lung cancer;
The ErbB receptor family has been implicated in brain metastases (BM) formation in various cancer types and specific targeted therapies are available. We investigated the overexpression of EGFR, HER2 and HER3 in BM of non-small cell lung cancer (NSCLC) patients to get a better insight on pathobiology of BM and potential drugable targets. We performed immunohistochemical analysis of EGFR, HER2 and HER3 on tissue microarrays of 131 NSCLC-BM. Fifty-one of 131 (38.9%) specimens were considered as positive for EGFR overexpression, 12/131 (9.2%) for HER2 and 27/131 (20.6%) for HER3 respectively. Sixty-nine of 131 (52.7%) of the cases showed overexpression of at least one marker. Four of 131 (3.1%) were positive for all three markers. Strong correlation was observed between HER2 and HER3 overexpression (p = 0.009; Chi-square test after Bonferroni-Holmes correction). No statistically significant correlation of EGFR, HER2 or HER3 overexpression with clinico-pathological parameters including overall survival times was observed. We observed overexpression of ErbB receptor family members, which represent established therapeutic targets in various primary tumours, in approximately half of NSCLC-BM. Further studies should investigate the role of the ErbB pathway in development of and as a therapeutic target in BM of NSCLC patients.