Epstein–Barr virus patterns in US Burkitt lymphoma tumors from the SEER residual tissue repository during 1979–2009
Article first published online: 23 APR 2013
© 2013 APMIS Published by Blackwell Publishing Ltd.
Volume 122, Issue 1, pages 5–15, January 2014
How to Cite
Epstein–Barr virus patterns in US Burkitt lymphoma tumors from the SEER residual tissue repository during 1979–2009. APMIS 2014; 122: 5–15., , , , , , , , , , , , , , , , .
- Issue published online: 27 DEC 2013
- Article first published online: 23 APR 2013
- Manuscript Accepted: 18 FEB 2013
- Manuscript Received: 9 OCT 2012
- Intramural Research Program of the Division of Cancer Epidemiology and Genetics
- National Cancer Institute
- National Institutes of Health
- Department of Health and Human Services. Grant Numbers: HHSN261200900444P, HHSN261200900586P, NO1-PC-35143, NO1-PC-35137, N01-PC-35139 N01-PC-2010-00035
- California Department of Health Services
- Centers for Disease Control and Prevention. Grant Number: 1U58DP000807-3
- Non-hodgkin lymphoma;
- burkitt lymphoma;
- epstein-barr virus;
Burkitt lymphoma (BL) occurs at all ages, but the patterns of Epstein–Barr virus (EBV) positivity in relation to human immunodeficiency virus (HIV), immunoprofiles and age have not been fully explored. BL tissues from residual tissue repositories, and two academic centers in the United States were examined by expert hematopathologists for morphology, immunohistochemistry, MYC rearrangement, EBV-encoded RNA (EBER), and diagnosed according to the 2008 WHO lymphoma classification. Analysis was done using frequency tables, Chi-squared statistics, and Student's t-test. Of 117 cases examined, 91 were confirmed as BL. The age distribution was 26%, 15%, 19%, and 29% for 0–19, 20–34, 35–59, 60+ years, and missing in 11%. MYC rearrangement was found in 89% and EBER positivity in 29% of 82 cases with results. EBER positivity varied with age (from 13% in age group 0–19 to 55% in age group 20–34, and fell to 25% in age group 60+ years, p = 0.08); with race (56% in Blacks/Hispanics vs 21% in Whites/Asians/Pacific Islanders, p = 0.006); and by HIV status (64% in HIV positive vs 22% in HIV negative cases, p = 0.03). EBER positivity was demonstrated in about one-third of tumors and it was strongly associated with race and HIV status, and marginally with age-group.