The human polyomaviruses: from orphans and mutants to patchwork family
Article first published online: 19 JUN 2013
© 2013 APMIS. Published by John Wiley & Sons Ltd
Volume 121, Issue 8, pages 681–684, August 2013
How to Cite
The human polyomaviruses: from orphans and mutants to patchwork family. APMIS 2013; 121: 681–4., .
- Issue published online: 9 JUL 2013
- Article first published online: 19 JUN 2013
- Manuscript Accepted: 5 MAY 2013
- Manuscript Received: 30 APR 2013
- Human polyomavirus;
- persistent infection;
- viral coexistence
For almost 40 years, polyomavirus JC and BK were the only known human polyomaviruses but in the last 7 years, increased interest and innovative molecular screening techniques have led to the identification of 10 previously unknown polyomaviruses in humans. Two of these, Merkel cell polyomavirus and Trichodysplasia spinulosa polyomavirus, have also been found to cause disease in immunocompromised patients. Seroprevalence studies indicate that human polyomaviruses are transmitted independently of one another in humans and carry different risks of exposure and reexposure throughout life. The potential coexistence of 12 or more different polyomavirus species in the same host and possibly even in the same organ raises the question of potential interactions. Careful review of polyomavirus biology may facilitate new discoveries concerning these formerly underestimated viral agents and their influence on human health.