W. Qiu and F. Zhou contributed equally to this work.
Overexpression of nucleolin and different expression sites both related to the prognosis of gastric cancer
Article first published online: 14 JUN 2013
© 2013 APMIS. Published by John Wiley & Sons Ltd
Volume 121, Issue 10, pages 919–925, October 2013
How to Cite
Overexpression of nucleolin and different expression sites both related to the prognosis of gastric cancer. APMIS 2013; 121: 919–925., , , , , , , .
- Issue published online: 20 SEP 2013
- Article first published online: 14 JUN 2013
- Manuscript Accepted: 27 APR 2013
- Manuscript Received: 8 NOV 2012
- Shandong Natural Science Foundation. Grant Number: Y2006C23
- Shandong Excellent Young Scientist Research Award Fund Project. Grant Numbers: 2006BSB14114, BS2010YY013
- Shandong Tackle Key Problems in Science and Technology. Grant Number: 2010GSF10245
- Gastric cancer;
- expression sites;
The aim of this study was to investigate the expression of nucleolin in tumorous tissues and corresponding non-malignant tissues in gastric cancer (GC), and the correlation of different expression sites with clinicopathologic parameters and prognosis. Immunohistochemistry was used for detecting the expression levels of nucleolin in GC tissues and corresponding non-malignant tissues from 124 gastrectomy specimens with stage I–III. Staining results were correlated with clinicopathologic features and survival. Both GC tissues and corresponding non-malignant tissues showed nucleolar staining for nucleolin. Nucleolin expression was higher in GC tissues than in non-malignant tissues. Among the 124 GCs, 85 (68.5%) were nucleolin-high. No significant correlation between nucleolin expression and other clinicopathologic parameters was found. The Cox univariate analysis indicated that both cytoplasmic staining and nucleolar staining of nucleolin expression correlated with patients' prognosis (log-rank, p < 0.0001; p = 0.0075, respectively). It was concluded in the study that nucleolin was overexpressed in GCs. A high level of nucleolar expression of nucleolin was an independent prognostic marker for better survival while high cytoplasmic staining was closely associated with worse prognosis for GC patients.