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References

  • 1
    Johne R, Buck CB, Allander T, Atwood WJ, Garcea RL, Imperiale MJ, et al. Taxonomical developments in the family Polyomaviridae. Arch Virol 2011;156:162734.
  • 2
    Melnick JL. Papova virus group. Science 1962;135:112830.
  • 3
    Knowles WA. Serendipity – the fortuitous discovery of BK virus. In: Khalili K, Stoner GL, editors. Human Polyomaviruses: Molecular and Clinical Perspectives. New York: John Wiley & Sons, 2002: 4551.
  • 4
    Gardner SD, Field AM, Coleman DV, Hulme B. New human papovavirus (B.K.) isolated from urine after renal transplantation. Lancet 1971;1:12537.
  • 5
    Padgett BL, Walker DL, ZuRhein GM, Eckroade RJ, Dessel BH. Cultivation of papova-like virus from human brain with progressive multifocal leucoencephalopathy. Lancet 1971;1:125760.
  • 6
    Allander T, Andreasson K, Gupta S, Bjerkner A, Bogdanovic G, Persson MA, et al. Identification of a third human polyomavirus. J Virol 2007;81:41306.
  • 7
    Gaynor AM, Nissen MD, Whiley DM, Mackay IM, Lambert SB, Wu G, et al. Identification of a novel polyomavirus from patients with acute respiratory tract infections. PLoS Pathog 2007;3:e64.
  • 8
    Feng H, Shuda M, Chang Y, Moore PS. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science 2008;319:1096100.
  • 9
    Schowalter RM, Pastrana DV, Pumphrey KA, Moyer AL, Buck CB. Merkel cell polyomavirus and two previously unknown polyomaviruses are chronically shed from human skin. Cell Host Microbe 2010;7:50915.
  • 10
    van der Meijden ME, Janssens RW, Lauber C, Bouwes Bavinck JN, Gorbalenya AE, Feltkamp MC. Discovery of a new human polyomavirus associated with trichodysplasia spinulosa in an immunocompromized patient. PLoS Pathog 2010;6:e1001024.
  • 11
    Scuda N, Hofmann J, Calvignac-Spencer S, Ruprecht K, Liman P, Kuhn J, et al. A novel human polyomavirus closely related to the african green monkey-derived lymphotropic polyomavirus. J Virol 2011;85:458690.
  • 12
    Buck CB, Phan GQ, Raiji MT, Murphy PM, McDermott DH, McBride AA. Complete genome sequence of a tenth human polyomavirus. J Virol 2012;86:10887.
  • 13
    Siebrasse EA, Reyes A, Lim ES, Zhao G, Mkakosya RS, Manary MJ, et al. Identification of MW polyomavirus, a novel polyomavirus in human stool. J Virol 2012;86:103216.
  • 14
    Yu G, Greninger AL, Isa P, Phan TG, Martinez MA, de la Luz Sanchez M, et al. Discovery of a novel polyomavirus in acute diarrheal samples from children. PLoS ONE 2012;7:e49449.
  • 15
    Lim ES, Reyes A, Antonio M, Saha D, Ikumapayi UN, Adeyemi M, et al. Discovery of STL polyomavirus, a polyomavirus of ancestral recombinant origin that encodes a unique T antigen by alternative splicing. Virology 2013;436:295303.
  • 16
    Korup S, Rietscher J, Calvignac-Spencer S, Trusch F, Hofmann J, Moens U, et al. Identification of a novel human polyomavirus in organs of the gastrointestinal tract. PLoS ONE 2013;8:e58021.
  • 17
    Takemoto KK, Mullarkey MF. Human papovavirus, BK strain: biological studies including antigenic relationship to simian virus 40. J Virol 1973;12:62531.
  • 18
    Li TC, Takeda N, Kato K, Nilsson J, Xing L, Haag L, et al. Characterization of self-assembled virus-like particles of human polyomavirus BK generated by recombinant baculoviruses. Virology 2003;311:11524.
  • 19
    Clever J, Dean DA, Kasamatsu H. Identification of a DNA binding domain in simian virus 40 capsid proteins Vp2 and Vp3. J Biol Chem 1993;268:2087783.
  • 20
    Cole CN. Polyomavirinae: the viruses and their replication. In: Fields BN, Knipe DM, Howley PM, editors. Fields Virology. Philadelphia: Lippincott-Raven,1996:19972025.
  • 21
    Meneguzzi G, Pignatti PF, Barbanti-Brodano G, Milanesi G. Minichromosome from BK virus as a template for transcription in vitro. Proc Natl Acad Sci USA 1978;75:112630.
  • 22
    Abend JR, Joseph AE, Das D, Campbell-Cecen DB, Imperiale MJ. A truncated T antigen expressed from an alternatively spliced BK virus early mRNA. J Gen Virol 2009;90:123845.
  • 23
    Pipas JM. Common and unique features of T antigens encoded by the polyomavirus group. J Virol 1992;66:397985.
  • 24
    Farrell MP, Mantyjarvi RA, Pagano JS. T antigen of BK papovavirus in infected and transformed cells. J Virol 1978;25:8717.
  • 25
    Seo GJ, Fink LH, O'Hara B, Atwood WJ, Sullivan CS. Evolutionarily conserved function of a viral microRNA. J Virol 2008;82:98238.
  • 26
    Bauman Y, Nachmani D, Vitenshtein A, Tsukerman P, Drayman N, Stern-Ginossar N, et al. An identical miRNA of the human JC and BK polyoma viruses targets the stress-induced ligand ULBP3 to escape immune elimination. Cell Host Microbe 2011;9:93102.
  • 27
    Rinaldo CH, Traavik T, Hey A. The agnogene of the human polyomavirus BK is expressed. J Virol 1998;72:62336.
  • 28
    Gerits N, Moens U. Agnoprotein of mammalian polyomaviruses. Virology 2012;432:31626.
  • 29
    Unterstab G, Gosert R, Leuenberger D, Lorentz P, Rinaldo CH, Hirsch HH. The polyomavirus BK agnoprotein co-localizes with lipid droplets. Virology 2010;399:32231.
  • 30
    Cioni MM, Mittelholzer C, Wenli M, Hirsch HH. Comparing effects of BK virus agnoprotein and herpes simplex-1 ICP47 on MHC-I and MHC-II expression. Clin Dev Immunol 2013;2013:626823.
  • 31
    Daniels R, Sadowicz D, Hebert DN. A very late viral protein triggers the lytic release of SV40. PLoS Pathog 2007;3:e98.
  • 32
    Raghava S, Giorda KM, Romano FB, Heuck AP, Hebert DN. The SV40 late protein VP4 is a viroporin that forms pores to disrupt membranes for viral release. PLoS Pathog 2011;7:e1002116.
  • 33
    Markowitz RB, Dynan WS. Binding of cellular proteins to the regulatory region of BK virus DNA. J Virol 1988;62:338898.
  • 34
    Moens U, Johansen T, Johnsen JI, Seternes OM, Traavik T. Noncoding control region of naturally occurring BK virus variants: sequence comparison and functional analysis. Virus Genes 1995;10:26175.
  • 35
    Randhawa P, Zygmunt D, Shapiro R, Vats A, Weck K, Swalsky P, et al. Viral regulatory region sequence variations in kidney tissue obtained from patients with BK virus nephropathy. Kidney Int 2003;64:7437.
  • 36
    Gosert R, Rinaldo CH, Funk GA, Egli A, Ramos E, Drachenberg CB, et al. Polyomavirus BK with rearranged noncoding control region emerge in vivo in renal transplant patients and increase viral replication and cytopathology. J Exp Med 2008;205:84152.
  • 37
    Olsen GH, Andresen PA, Hilmarsen HT, Bjorang O, Scott H, Midtvedt K, et al. Genetic variability in BK virus regulatory regions in urine and kidney biopsies from renal-transplant patients. J Med Virol 2006;78:38493.
  • 38
    Hanssen RC, Hansen H, Traavik T. Human endothelial cells allow passage of an archetypal BK virus (BKV) strain – a tool for cultivation and functional studies of natural BKV strains. Arch Virol 2005;150:144958.
  • 39
    Egli A, Infanti L, Dumoulin A, Buser A, Samaridis J, Stebler C, et al. Prevalence of polyomavirus BK and JC infection and replication in 400 healthy blood donors. J Infect Dis 2009;199:83746.
  • 40
    Sharma PM, Gupta G, Vats A, Shapiro R, Randhawa PS. Polyomavirus BK non-coding control region rearrangements in health and disease. J Med Virol 2007;79:1199207.
  • 41
    Carr MJ, McCormack GP, Mutton KJ, Crowley B. Unique BK virus non-coding control region (NCCR) variants in hematopoietic stem cell transplant recipients with and without hemorrhagic cystitis. J Med Virol 2006;78:48593.
  • 42
    Yoshiike K, Takemoto KK. Studies with BK virus and monkey lymphotropic papovavirus. In: Salzman NP, editor. The Papovaviridae. New York: Plenum Publishing Corp., 1986: 295326.
  • 43
    Dugan AS, Eash S, Atwood WJ. An N-linked glycoprotein with alpha(2,3)-linked sialic acid is a receptor for BK virus. J Virol 2005;79:144425.
  • 44
    Low JA, Magnuson B, Tsai B, Imperiale MJ. Identification of gangliosides GD1b and GT1b as receptors for BK virus. J Virol 2006;80:13616.
  • 45
    Eash S, Querbes W, Atwood WJ. Infection of vero cells by BK virus is dependent on caveolae. J Virol 2004;78:1158390.
  • 46
    Nakanishi A, Li PP, Qu Q, Jafri QH, Kasamatsu H. Molecular dissection of nuclear entry-competent SV40 during infection. Virus Res 2007;124:22630.
  • 47
    Maraldi NM, Barbanti-Brodano G, Portolani M, La Placa M. Ultrastructural aspects of BK virus uptake and replication in human fibroblasts. J Gen Virol 1975;27:7180.
  • 48
    Harris KF, Christensen JB, Imperiale MJ. BK virus large T antigen: interactions with the retinoblastoma family of tumor suppressor proteins and effects on cellular growth control. J Virol 1996;70:237886.
  • 49
    White MK, Khalili K. Interaction of retinoblastoma protein family members with large T-antigen of primate polyomaviruses. Oncogene 2006;25:528693.
  • 50
    Cuesta I, Nunez-Ramirez R, Scheres SH, Gai D, Chen XS, Fanning E, et al. Conformational rearrangements of SV40 large T antigen during early replication events. J Mol Biol 2010;397:127686.
  • 51
    Seemayer CA, Seemayer NH, Durmuller U, Gudat F, Schaub S, Hirsch HH, et al. BK virus large T and VP-1 expression in infected human renal allografts. Nephrol Dial Transplant 2008;12:375261.
  • 52
    Drachenberg CB, Papadimitriou JC, Wali R, Cubitt CL, Ramos E. BK polyoma virus allograft nephropathy: ultrastructural features from viral cell entry to lysis. Am J Transplant 2003;3:138392.
  • 53
    Nickeleit V, Singh HK, Mihatsch MJ. Polyomavirus nephropathy: morphology, pathophysiology, and clinical management. Curr Opin Nephrol Hypertens 2003;12:599605.
  • 54
    Li R, Sharma BN, Linder S, Gutteberg TJ, Hirsch HH, Rinaldo CH. Characteristics of polyomavirus BK (BKPyV) infection in primary human urothelial cells. Virology 2013;440:4150.
  • 55
    Nukuzuma S, Takasaka T, Zheng HY, Zhong S, Chen Q, Kitamura T, et al. Subtype I BK polyomavirus strains grow more efficiently in human renal epithelial cells than subtype IV strains. J Gen Virol 2006;87:1893901.
  • 56
    Olsen GH, Hirsch HH, Rinaldo CH. Functional analysis of polyomavirus BK non-coding control region quasispecies from kidney transplant recipients. J Med Virol 2009;81:195967.
  • 57
    Myhre MR, Olsen GH, Gosert R, Hirsch HH, Rinaldo CH. Clinical polyomavirus BK variants with agnogene deletion are non-functional but rescued by trans-complementation. Virology 2010;398:1220.
  • 58
    Broekema NM, Imperiale MJ. Efficient propagation of archetype BK and JC polyomaviruses. Virology 2012;422:23541.
  • 59
    Gorrill T, Feliciano M, Mukerjee R, Sawaya BE, Khalili K, White MK. Activation of early gene transcription in polyomavirus BK by human immunodeficiency virus type 1 Tat. J Gen Virol 2006;87:155766.
  • 60
    Hirsch HH, Steiger J. Polyomavirus BK. Lancet Infect Dis 2003;3:61123.
  • 61
    Knowles WA, Pipkin P, Andrews N, Vyse A, Minor P, Brown DW, et al. Population-based study of antibody to the human polyomaviruses BKV and JCV and the simian polyomavirus SV40. J Med Virol 2003;71:11523.
  • 62
    Chesters PM, Heritage J, McCance DJ. Persistence of DNA sequences of BK virus and JC virus in normal human tissues and in diseased tissues. J Infect Dis 1983;147:67684.
  • 63
    Kling CL, Wright AT, Katz SE, McClure GB, Gardner JS, Williams JT, et al. Dynamics of urinary polyomavirus shedding in healthy adult women. J Med Virol 2012;84:145963.
  • 64
    Polo C, Perez JL, Mielnichuck A, Fedele CG, Niubo J, Tenorio A. Prevalence and patterns of polyomavirus urinary excretion in immunocompetent adults and children. Clin Microbiol Infect 2004;10:6404.
  • 65
    Hirsch HH, Randhawa P, Practice TIDCo. BK polyomavirus in solid organ transplantation. Am J Transplant2013;13(Suppl 4):17988.
  • 66
    Hirsch HH, Knowles W, Dickenmann M, Passweg J, Klimkait T, Mihatsch MJ, et al. Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients. N Engl J Med 2002;347:48896.
  • 67
    Singh HK, Donna TB, Nickeleit V. Viral Haufen are urinary biomarkers of polyomavirus nephropathy: new diagnostic strategies utilizing negative staining electron microscopy. Ultrastruct Pathol 2009;33:22235.
  • 68
    Knowles WA, Gibson PE, Gardner SD. Serological typing scheme for BK-like isolates of human polyomavirus. J Med Virol 1989;28:11823.
  • 69
    Jin L, Gibson PE, Knowles WA, Clewley JP. BK virus antigenic variants: sequence analysis within the capsid VP1 epitope. J Med Virol 1993;39:506.
  • 70
    Zheng HY, Nishimoto Y, Chen Q, Hasegawa M, Zhong S, Ikegaya H, et al. Relationships between BK virus lineages and human populations. Microbes Infect 2007;9:20413.
  • 71
    Nishimoto Y, Zheng HY, Zhong S, Ikegaya H, Chen Q, Sugimoto C, et al. An Asian origin for subtype IV BK virus based on phylogenetic analysis. J Mol Evol 2007;65:10311.
  • 72
    Luo C, Hirsch HH, Kant J, Randhawa P. VP-1 quasispecies in human infection with polyomavirus BK. J Med Virol 2012;84:15261.
  • 73
    Kean JM, Rao S, Wang M, Garcea RL. Seroepidemiology of human polyomaviruses. PLoS Pathog 2009;5:e1000363.
  • 74
    Coleman DV, Mackenzie EF, Gardner SD, Poulding JM, Amer B, Russell WJ. Human polyomavirus (BK) infection and ureteric stenosis in renal allograft recipients. J Clin Pathol 1978;31:33847.
  • 75
    Mackenzie EF, Poulding JM, Harrison PR, Amer B. Human polyoma virus (HPV)–a significant pathogen in renal transplantation. Proc Eur Dial Transplant Assoc 1978;15:35260.
  • 76
    Purighalla R, Shapiro R, McCauley J, Randhawa P. BK virus infection in a kidney allograft diagnosed by needle biopsy. Am J Kidney Dis 1995;26:6713.
  • 77
    Binet I, Nickeleit V, Hirsch HH, Prince O, Dalquen P, Gudat F, et al. Polyomavirus disease under new immunosuppressive drugs: a cause of renal graft dysfunction and graft loss. Transplantation 1999;67:91822.
  • 78
    Nickeleit V, Hirsch HH, Binet IF, Gudat F, Prince O, Dalquen P, et al. Polyomavirus infection of renal allograft recipients: from latent infection to manifest disease. J Am Soc Nephrol 1999;10:10809.
  • 79
    Randhawa PS, Finkelstein S, Scantlebury V, Shapiro R, Vivas C, Jordan M, et al. Human polyoma virus-associated interstitial nephritis in the allograft kidney. Transplantation 1999;67:1039.
  • 80
    Ramos E, Drachenberg CB, Portocarrero M, Wali R, Klassen DK, Fink JC, et al. BK virus nephropathy diagnosis and treatment: experience at the University of Maryland Renal Transplant Program. Clin Transpl 2002;14353.
  • 81
    Sharma SG, Nickeleit V, Herlitz LC, de Gonzalez AK, Stokes MB, Singh HK, et al. BK polyoma virus nephropathy in the native kidney. Nephrol Dial Transplant 2013;28:62031.
  • 82
    Brennan DC, Aguado JM, Potena L, Jardine AG, Legendre C, Saemann MD, et al. Effect of maintenance immunosuppressive drugs on virus pathobiology: evidence and potential mechanisms. Rev Med Virol 2013;23:97125.
  • 83
    Hirsch HH. Polyoma and papilloma virus infections after hematopoietic stem cell or solid organ transplantation In: Bowden P, Ljungman P, Snydman DR, editors. Transplant Infections. New York: Lippincott Williams & Wilkins, 2010: 46582.
  • 84
    Funk GA, Gosert R, Comoli P, Ginevri F, Hirsch HH. Polyomavirus BK replication dynamics in vivo and in silico to predict cytopathology and viral clearance in kidney transplants. Am J Transplant 2008;8:236877.
  • 85
    Azzi A, Cesaro S, Laszlo D, Zakrzewska K, Ciappi S, de Santis R, et al. Human polyomavirus BK (BKV) load and haemorrhagic cystitis in bone marrow transplantation patients. J Clin Virol 1999;14:7986.
  • 86
    Binet I, Nickeleit V, Hirsch HH. Polyomavirus infection in transplant recipients. Curr Opin Organ Transplant 2000;5:2106.
  • 87
    Kinnaird AN, Anstead GM. Hemorrhagic cystitis and possible neurologic disease from BK virus infection in a patient with AIDS. Infection 2010;38:1247.
  • 88
    Rajpoot DK, Gomez A, Tsang W, Shanberg A. Ureteric and urethral stenosis: a complication of BK virus infection in a pediatric renal transplant patient. Pediatr Transplant 2007;11:4335.
  • 89
    Chang CY, Gangji A, Chorneyko K, Kapoor A. Urological manifestations of BK polyomavirus in renal transplant recipients. Can J Urol 2005;12:282936.
  • 90
    van Aalderen MC, Yapici U, van der Pol JA, de Reijke TM, van Donselaar-van der Pant KA, Florquin S, et al. Polyomavirus BK in the pathogenesis of bladder cancer. Neth J Med 2013;71:268.
  • 91
    Hwang YY, Sim J, Leung AY, Lie AK, Kwong YL. BK virus-associated bilateral ureteric stenosis after haematopoietic SCT: viral kinetics and successful treatment. Bone Marrow Transplant 2013;48:7456.
  • 92
    Khan H, Oberoi S, Mahvash A, Sharma M, Rondon G, Alousi A, et al. Reversible ureteral obstruction due to polyomavirus infection after percutaneous nephrostomy catheter placement. Biol Blood Marrow Transplant 2011;17:15515.
  • 93
    van Gorder MA, Della PP, Henson JW, Sachs DH, Cosimi AB, Colvin RB. Cynomolgus polyoma virus infection: a new member of the polyoma virus family causes interstitial nephritis, ureteritis, and enteritis in immunosuppressed cynomolgus monkeys. Am J Pathol 1999;154:127384.
  • 94
    Brennan DC, Agha I, Bohl DL, Schnitzler MA, Hardinger KL, Lockwood M, et al. Incidence of BK with tacrolimus versus cyclosporine and impact of preemptive immunosuppression reduction. Am J Transplant 2005;5:58294.
  • 95
    Hirsch HH. BK virus: opportunity makes a pathogen. Clin Infect Dis 2005;41:35460.
  • 96
    Bratt G, Hammarin AL, Grandien M, Hedquist BG, Nennesmo I, Sundelin B, et al. BK virus as the cause of meningoencephalitis, retinitis and nephritis in a patient with AIDS. AIDS 1999;13:10715.
  • 97
    Stoner GL, Alappan R, Jobes DV, Ryschkewitsch CF, Landry ML. BK virus regulatory region rearrangements in brain and cerebrospinal fluid from a leukemia patient with tubulointerstitial nephritis and meningoencephalitis. Am J Kidney Dis 2002;39:110212.
  • 98
    Behzad-Behbahani A, Klapper PE, Vallely PJ, Cleator GM. BK virus DNA in CSF of immunocompetent and immunocompromised patients. Arch Dis Child 2003;88:1745.
  • 99
    Lopes da Silva R, Ferreira I, Teixeira G, Cordeiro D, Mafra M, Costa I, et al. BK virus encephalitis with thrombotic microangiopathy in an allogeneic hematopoietic stem cell transplant recipient. Transpl Infect Dis 2011;13:1617.
  • 100
    Behre G, Becker M, Christopeit M. BK virus encephalitis in an allogeneic hematopoietic stem cell recipient. Bone Marrow Transplant 2008;42:499.
  • 101
    Friedman DP, Flanders AE. MR imaging of BK virus encephalitis. AJNR Am J Neuroradiol 2006;27:10168.
  • 102
    Lesprit P, Chaline-Lehmann D, Authier FJ, Ponnelle T, Gray F, Levy Y. BK virus encephalitis in a patient with AIDS and lymphoma. AIDS 2001;15:11969.
  • 103
    Voltz R, Jager G, Seelos K, Fuhry L, Hohlfeld R. BK virus encephalitis in an immunocompetent patient. Arch Neurol 1996;53:1013.
  • 104
    Vallbracht A, Lohler J, Gossmann J, Gluck T, Petersen D, Gerth HJ, et al. Disseminated BK type polyomavirus infection in an AIDS patient associated with central nervous system disease. Am J Pathol 1993;143:2939.
  • 105
    Green J, Saigal G, Rojas CP, Post MJ. Rare presentation of BK encephalitis in a child: imaging and pathological findings. Pediatr Radiol 2012;42:11458.
  • 106
    Pereira T, Rojas CP, Garcia-Buitrago MT, Chandar J, Abitbol C, Seeherunvong W, et al. A child with BK virus infection: inadequacy of current therapeutic strategies. Pediatr Transplant 2012;16:E26974.
  • 107
    Hix JK, Braun WE, Isada CM. Delirium in a renal transplant recipient associated with BK virus in the cerebrospinal fluid. Transplantation 2004;78:14078.
  • 108
    Daveson KL, Ong CW, Bowden S, Koina ME, Hallam LA. BK virus-associated progressive multifocal leukoencephalopathy. Med J Aust 2013;198:2168.
  • 109
    Marshall J, Smith AE, Cheng SH. Monoclonal antibody specific for BK virus large-T antigen allows discrimination among the different papovaviral large-T antigens. Oncogene 1991;6:16736.
  • 110
    Zambrano A, Villarreal LP. A monoclonal antibody specific for BK virus large T-antigen (clone BK.T-1) also binds the human Ku autoantigen. Oncogene 2002;21:572532.
  • 111
    Dalianis T, Hirsch HH. BK polyomavirus and transformation. In: Robertson ES, editor. Cancer Associated Viruses. New York: Springer Science + Business Media, 2012: 41932.
  • 112
    Abend JR, Jiang M, Imperiale MJ. BK virus and human cancer: innocent until proven guilty. Semin Cancer Biol 2009;19:25260.
  • 113
    Dalianis T, Hirsch HH. Human polyomaviruses in disease and cancer. Virology 2013;437:6372.
  • 114
    Bouvard V, Baan RA, Grosse Y, Lauby-Secretan B, El Ghissassi F, Benbrahim-Tallaa L, et al. Carcinogenicity of malaria and of some polyomaviruses. Lancet Oncol 2012;13:33940.
  • 115
    Robles C, Viscidi R, Malats N, Silverman DT, Tardon A, Garcia-Closas R, et al. Bladder cancer and seroreactivity to BK, JC and Merkel cell polyomaviruses: the Spanish bladder cancer study. Int J Cancer 2013;133:597603.
  • 116
    Petrogiannis-Haliotis T, Sakoulas G, Kirby J, Koralnik IJ, Dvorak AM, Monahan-Earley R, et al. BK-related polyomavirus vasculopathy in a renal-transplant recipient. N Engl J Med 2001;345:12505.
  • 117
    Medeiros PV, Abagge KT, Carvalho VO, Bonfim CM, Raboni SM. Polyomavirus BK: possibly associated skin eruption in a patient with hemorrhagic cystitis. Pediatr Dermatol 2011;28:767.
  • 118
    Sandler ES, Aquino VM, Goss Shohet E, Hinrichs S, Krisher K. BK papova virus pneumonia following hematopoietic stem cell transplantation. Bone Marrow Transplant 1997;20:1635.
  • 119
    Randhawa P, Ho A, Shapiro R, Vats A, Swalsky P, Finkelstein S, et al. Correlates of quantitative measurement of BK polyomavirus (BKV) DNA with clinical course of BKV infection in renal transplant patients. J Clin Microbiol 2004;42:117680.
  • 120
    Trofe-Clark J, Sparkes T, Gentile C, Van Deerlin V, Sawinski D, Bloom RD. BK virus genotype variance and discordant BK viremia PCR assay results. Am J Transplant 2013;13:11123.
  • 121
    Randhawa P, Kant J, Shapiro R, Tan H, Basu A, Luo C. Impact of genomic sequence variability on quantitative PCR assays for diagnosis of polyomavirus BK infection. J Clin Microbiol 2011;49:40726.
  • 122
    Dumoulin A, Hirsch HH. Reevaluating and optimizing polyomavirus BK and JC real-time PCR assays to detect rare sequence polymorphisms. J Clin Microbiol 2011;49:13828.
  • 123
    Hirsch HH, Brennan DC, Drachenberg CB, Ginevri F, Gordon J, Limaye AP, et al. Polyomavirus-associated nephropathy in renal transplantation: interdisciplinary analyses and recommendations. Transplantation 2005;79:127786.
  • 124
    Sar A, Worawichawong S, Benediktsson H, Zhang J, Yilmaz S, Trpkov K. Interobserver agreement for Polyomavirus nephropathy grading in renal allografts using the working proposal from the 10th Banff Conference on Allograft Pathology. Hum Pathol 2011;42:201824.
  • 125
    Koskenvuo M, Dumoulin A, Lautenschlager I, Auvinen E, Mannonen L, Anttila VJ, et al. BK polyomavirus-associated hemorrhagic cystitis among pediatric allogeneic bone marrow transplant recipients: treatment response and evidence for nosocomial transmission. J Clin Virol 2013;56:7781.
  • 126
    Erard V, Kim HW, Corey L, Limaye A, Huang ML, Myerson D, et al. BK DNA viral load in plasma: evidence for an association with hemorrhagic cystitis in allogeneic hematopoietic cell transplant recipients. Blood 2005;106:11302.
  • 127
    Drew RJ, Walsh A, Ni Laoi B, Conneally E, Crowley B. BK virus (BKV) plasma dynamics in patients with BKV-associated hemorrhagic cystitis following allogeneic stem cell transplantation. Transpl Infect Dis 2013;15:27682.
  • 128
    Rinaldo CH, Hirsch HH. Antivirals for the treatment of polyomavirus BK replication. Expert Rev Anti Infect Ther 2007;5:10515.
  • 129
    Hardinger KL, Koch MJ, Bohl DJ, Storch GA, Brennan DC. BK-virus and the impact of pre-emptive immunosuppression reduction: 5-year results. Am J Transplant 2010;10:40715.
  • 130
    Schaub S, Hirsch HH, Dickenmann M, Steiger J, Mihatsch MJ, Hopfer H, et al. Reducing immunosuppression preserves allograft function in presumptive and definitive polyomavirus-associated nephropathy. Am J Transplant 2010;10:261523.
  • 131
    Ginevri F, Azzi A, Hirsch HH, Basso S, Fontana I, Cioni M, et al. Prospective monitoring of polyomavirus BK replication and impact of pre-emptive intervention in pediatric kidney recipients. Am J Transplant 2007;7:272735.
  • 132
    Menter T, Mayr M, Schaub S, Mihatsch MJ, Hirsch HH, Hopfer H. Pathology of resolving polyomavirus-associated nephropathy. Am J Transplant 2013. doi: 10.1002/ajt.12218.
  • 133
    Johnston O, Jaswal D, Gill JS, Doucette S, Fergusson DA, Knoll GA. Treatment of polyomavirus infection in kidney transplant recipients: a systematic review. Transplantation 2010;89:105770.
  • 134
    Held TK, Biel SS, Nitsche A, Kurth A, Chen S, Gelderblom HR, et al. Treatment of BK virus-associated hemorrhagic cystitis and simultaneous CMV reactivation with cidofovir. Bone Marrow Transplant 2000;26:34750.
  • 135
    Bjorang O, Tveitan H, Midtvedt K, Broch LU, Scott H, Andresen PA. Treatment of polyomavirus infection with cidofovir in a renal-transplant recipient. Nephrol Dial Transplant 2002;17:20235.
  • 136
    Cihlar T, Chen MS. Identification of enzymes catalyzing two-step phosphorylation of cidofovir and the effect of cytomegalovirus infection on their activities in host cells. Mol Pharmacol 1996;50:150210.
  • 137
    De Clercq E. The acyclic nucleoside phosphonates from inception to clinical use: historical perspective. Antiviral Res 2007;75:113.
  • 138
    Xiong X, Smith JL, Chen MS. Effect of incorporation of cidofovir into DNA by human cytomegalovirus DNA polymerase on DNA elongation. Antimicrob Agents Chemother 1997;41:5949.
  • 139
    Farasati NA, Shapiro R, Vats A, Randhawa P. Effect of leflunomide and cidofovir on replication of BK virus in an in vitro culture system. Transplantation 2005;79:1168.
  • 140
    Bernhoff E, Gutteberg TJ, Sandvik K, Hirsch HH, Rinaldo CH. Cidofovir inhibits polyomavirus BK replication in human renal tubular cells downstream of viral early gene expression. Am J Transplant 2008;8:141322.
  • 141
    Izzedine H, Launay-Vacher V, Deray G. Antiviral drug-induced nephrotoxicity. Am J Kidney Dis 2005;45:80417.
  • 142
    Rinaldo CH, Gosert R, Bernhoff E, Finstad S, Hirsch HH. 1-O-hexadecyloxypropyl cidofovir (CMX001) effectively inhibits polyomavirus BK replication in primary human renal tubular epithelial cells. Antimicrob Agents Chemother 2010;54:471422.
  • 143
    Painter W, Robertson A, Trost LC, Godkin S, Lampert B, Painter G. First pharmacokinetic and safety study in humans of the novel lipid antiviral conjugate CMX001, a broad-spectrum oral drug active against double-stranded DNA viruses. Antimicrob Agents Chemother 2012;56:272634.
  • 144
    Williams JW, Mital D, Chong A, Kottayil A, Millis M, Longstreth J, et al. Experiences with leflunomide in solid organ transplantation. Transplantation 2002;73:35866.
  • 145
    Knight DA, Hejmanowski AQ, Dierksheide JE, Williams JW, Chong AS, Waldman WJ. Inhibition of herpes simplex virus type 1 by the experimental immunosuppressive agent leflunomide. Transplantation 2001;71:1704.
  • 146
    Waldman WJ, Knight DA, Blinder L, Shen J, Lurain NS, Miller DM, et al. Inhibition of cytomegalovirus in vitro and in vivo by the experimental immunosuppressive agent leflunomide. Intervirology 1999;42:4128.
  • 147
    Foster PF, Wright F, McLean D, Schultz M, Romani L, Bannayan G, et al. Leflunomide administration as an adjunct in treatment of BK-polyoma viral disease in kidney allografts [abstract]. Am J Transplant 2003; 3(Suppl 5): A 421.
  • 148
    Poduval RD, Kadambi PV, Javaid B, Meehan SM,Harland RC, Foster PF. Leflunomide: a potential new therapeutic agent for BK nephropathy [abstract]. Am J Transplant 2003; 3(Suppl 5): A 189.
  • 149
    Leca N, Muczynski KA, Jefferson JA, de Boer IH, Kowalewska J, Kendrick EA, et al. Higher levels of leflunomide are associated with hemolysis and are not superior to lower levels for BK virus clearance in renal transplant patients. Clin J Am Soc Nephrol 2008;3:82935.
  • 150
    Bernhoff E, Tylden GD, Kjerpeseth LJ, Gutteberg TJ, Hirsch HH, Rinaldo CH. Leflunomide inhibition of BK virus replication in renal tubular epithelial cells. J Virol 2010;84:21506.
  • 151
    Josephson MA, Gillen D, Javaid B, Kadambi P, Meehan S, Foster P, et al. Treatment of renal allograft polyoma BK virus infection with leflunomide. Transplantation 2006;81:70410.
  • 152
    Dheir H, Sahin S, Uyar M, Gurkan A, Turunc V, Kacar S, et al. Intensive polyoma virus nephropathy treatment as a preferable approach for graft surveillance. Transplant Proc 2011;43:86770.
  • 153
    Teschner S, Gerke P, Geyer M, Wilpert J, Krumme B, Benzing T, et al. Leflunomide therapy for polyomavirus-induced allograft nephropathy: efficient BK virus elimination without increased risk of rejection. Transplant Proc 2009;41:25338.
  • 154
    Bansal S, Lucia MS, Wiseman A. A case of polyomavirus-associated nephropathy presenting late after transplantation. Nat Clin Pract Nephrol 2008;4:2837.
  • 155
    Jung YH, Moon KC, Ha JW, Kim SJ, Ha IS, Cheong HI, et al. Leflunomide therapy for BK virus allograft nephropathy after pediatric kidney transplantation. Pediatr Transplant 2013;17:E504.
  • 156
    O'Donnell PH, Swanson K, Josephson MA, Artz AS, Parsad SD, Ramaprasad C, et al. BK virus infection is associated with hematuria and renal impairment in recipients of allogeneic hematopoetic stem cell transplants. Biol Blood Marrow Transplant 2009;15:103848.
  • 157
    Faguer S, Hirsch HH, Kamar N, Guilbeau-Frugier C, Ribes D, Guitard J, et al. Leflunomide treatment for polyomavirus BK-associated nephropathy after kidney transplantation. Transpl Int 2007;20:9629.
  • 158
    Andriole VT. Fleroxacin: the newly introduced once-daily quinoline. Int J Antimicrob Agents 1994;4(Suppl 2):S16.
  • 159
    Ali SH, Chandraker A, DeCaprio JA. Inhibition of Simian virus 40 large T antigen helicase activity by fluoroquinolones. Antivir Ther 2007;12:16.
  • 160
    Ferrazzi E, Peracchi M, Biasolo MA, Faggionato O, Stefanelli S, Palu G. Antiviral activity of gyrase inhibitors norfloxacin, coumermycin A1 and nalidixic acid. Biochem Pharmacol 1988;37:18856.
  • 161
    Portolani M, Pietrosemoli P, Cermelli C, Mannini-Palenzona A, Grossi MP, Paolini L, et al. Suppression of BK virus replication and cytopathic effect by inhibitors of prokaryotic DNA gyrase. Antiviral Res 1988;9:20518.
  • 162
    Leung AY, Chan MT, Yuen KY, Cheng VC, Chan KH, Wong CL, et al. Ciprofloxacin decreased polyoma BK virus load in patients who underwent allogeneic hematopoietic stem cell transplantation. Clin Infect Dis 2005;40:52837.
  • 163
    Randhawa PS. Anti-BK virus activity of ciprofloxacin and related antibiotics. Clin Infect Dis 2005;41:13667.
  • 164
    Sharma BN, Li R, Bernhoff E, Gutteberg TJ, Rinaldo CH. Fluoroquinolones inhibit human polyomavirus BK (BKV) replication in primary human kidney cells. Antiviral Res 2011;92:11523.
  • 165
    Gabardi S, Waikar SS, Martin S, Roberts K, Chen J, Borgi L, et al. Evaluation of fluoroquinolones for the prevention of BK viremia after renal transplantation. Clin J Am Soc Nephrol 2010;5:1298304.
  • 166
    Miller AN, Glode A, Hogan KR, Schaub C, Kramer C, Stuart RK, et al. Efficacy and safety of ciprofloxacin for prophylaxis of polyomavirus BK virus-associated hemorrhagic cystitis in allogeneic hematopoietic stem cell transplantation recipients. Biol Blood Marrow Transplant 2011;17:117681.
  • 167
    Wojciechowski D, Chanda R, Chandran S, Lee B, Webber A, Macaraig M, et al. Ciprofloxacin prophylaxis in kidney transplant recipients reduces BK virus infection at 3 months but not at 1 year. Transplantation 2012;94:111723.
  • 168
    Koukoulaki M, Apostolou T, Hadjiconstantinou V, Drakopoulos S. Impact of prophylactic administration of ciprofloxacin on BK polyoma virus replication. Transpl Infect Dis 2008;10:44951.
  • 169
    Gelfand EW. Intravenous immune globulin in autoimmune and inflammatory diseases. N Engl J Med 2012;367:201525.
  • 170
    Randhawa PS, Schonder K, Shapiro R, Farasati N, Huang Y. Polyomavirus BK neutralizing activity in human immunoglobulin preparations. Transplantation 2010;89:14625.
  • 171
    Sener A, House AA, Jevnikar AM, Boudville N, McAlister VC, Muirhead N, et al. Intravenous immunoglobulin as a treatment for BK virus associated nephropathy: one-year follow-up of renal allograft recipients. Transplantation 2006;81:11720.
  • 172
    Sharma AP, Moussa M, Casier S, Rehman F, Filler G, Grimmer J. Intravenous immunoglobulin as rescue therapy for BK virus nephropathy. Pediatr Transplant 2009;13:1239.
  • 173
    Anyaegbu EI, Almond PS, Milligan T, Allen WR, Gharaybeh S, Al-Akash SI. Intravenous immunoglobulin therapy in the treatment of BK viremia and nephropathy in pediatric renal transplant recipients. Pediatr Transplant 2012;16:E1924.
  • 174
    Filler G, Licht C, Haig A.Native kidney BK virus nephropathy associated with acute lymphocytic leukemia. Pediatr Nephrol 2013;28:97981.
  • 175
    Wadei HM, Rule AD, Lewin M, Mahale AS, Khamash HA, Schwab TR, et al. Kidney transplant function and histological clearance of virus following diagnosis of polyomavirus-associated nephropathy (PVAN). Am J Transplant 2006l;6:102532.
  • 176
    Maggiore U, Medici MC, Vaglio A, Buzio C. Increased viral load after intravenous immunoglobulin therapy for BK virus-associated nephropathy. Transpl Infect Dis 2010;12:4702.
  • 177
    Bohl DL, Brennan DC, Ryschkewitsch C, Gaudreault-Keener M, Major EO, Storch GA. BK virus antibody titers and intensity of infections after renal transplantation. J Clin Virol 2008;43:1849.
  • 178
    Orbach H, Katz U, Sherer Y, Shoenfeld Y. Intravenous immunoglobulin: adverse effects and safe administration. Clin Rev Allergy Immunol 2005;29:17384.
  • 179
    Ortiz A, Justo P, Sanz A, Melero R, Caramelo C, Guerrero MF, et al. Tubular cell apoptosis and cidofovir-induced acute renal failure. Antivir Ther 2005;10:18590.
  • 180
    Focosi D, Maggi F, Pistolesi D, Benedetti E, Papineschi F, Galimberti S, et al. Hyperbaric oxygen therapy in BKV-associated hemorrhagic cystitis refractory to intravenous and intravesical cidofovir: case report and review of literature. Leuk Res 2009;33:55660.
  • 181
    Savva-Bordalo J, Pinho Vaz C, Sousa M, Branca R, Campilho F, Resende R, et al. Clinical effectiveness of hyperbaric oxygen therapy for BK-virus-associated hemorrhagic cystitis after allogeneic bone marrow transplantation. Bone Marrow Transplant 2012;47:10958.
  • 182
    Bogris SL, Johal NS, Hussein I, Duffy PG, Mushtaq I. Is it safe to use aluminum in the treatment of pediatric hemorrhagic cystitis? A case discussion of aluminum intoxication and review of the literature. J Pediatr Hematol Oncol 2009;31:2858.
  • 183
    Joseph CM, Bowley DM, Pitcher GJ. Formalin treatment of refractory hemorrhagic cystitis. J Pediatr Urol 2005;1:3657.
  • 184
    Leuenberger D, Andresen PA, Gosert R, Binggeli S, Strom EH, Bodaghi S, et al. Human polyomavirus type 1 (BK virus) agnoprotein is abundantly expressed but immunologically ignored. Clin Vaccine Immunol 2007;14:95968.