This uncommissioned review article was subject to full peer-review.
Review article: a comparison of glucagon-like peptides 1 and 2
Article first published online: 5 NOV 2012
© 2012 Blackwell Publishing Ltd
Alimentary Pharmacology & Therapeutics
Volume 37, Issue 1, pages 18–36, January 2013
How to Cite
Janssen, P., Rotondo, A., Mulé, F. and Tack, J. (2013), Review article: a comparison of glucagon-like peptides 1 and 2. Alimentary Pharmacology & Therapeutics, 37: 18–36. doi: 10.1111/apt.12092
- Issue published online: 4 DEC 2012
- Article first published online: 5 NOV 2012
- Manuscript Accepted: 29 SEP 2012
- Manuscript Revised: 20 SEP 2012
- Manuscript Revised: 9 JUL 2012
- Manuscript Received: 12 JUN 2012
- NPS Pharmaceuticals
- Ministero dell'Istruzione
Recent advancements in understanding the roles and functions of glucagon-like peptide 1 (GLP-1) and 2 (GLP-2) have provided a basis for targeting these peptides in therapeutic strategies.
To summarise the preclinical and clinical research supporting the discovery of new therapeutic molecules targeting GLP-1 and GLP-2.
This review is based on a comprehensive PubMed search, representing literature published during the past 30 years related to GLP-1 and GLP-2.
Although produced and secreted together primarily from L cells of the intestine in response to ingestion of nutrients, GLP-1 and GLP-2 exhibit distinctive biological functions that are governed by the expression of their respective receptors, GLP-1R and GLP-2R. Through widespread expression in the pancreas, intestine, nervous tissue, et cetera, GLP-1Rs facilitates an incretin effect along with effects on appetite and satiety. GLP-1 analogues resistant to degradation by dipeptidyl peptidase-IV and inhibitors of dipeptidyl peptidase-IV have been developed to aid treatment of diabetes and obesity. The GLP-2R is expressed almost exclusively in the stomach and bowel. The most apparent role for GLP-2 is its promotion of growth and function of intestinal mucosa, which has been targeted for therapies that promote repair and adaptive growth. These are used as treatments for intestinal failure and related conditions.
Our growing understanding of the biology and function of GLP-1, GLP-2 and corresponding receptors has fostered further discovery of fundamental biological function as well as new categories of potent therapeutic medicines.