NICE clinical guideline (CG152): the management of Crohn's disease in adults, children and young people

Authors


Correspondence to:

Prof. J. F. Mayberry, Department of Digestive Diseases, University Hospitals of Leicester NHS Trust, Leicester, LE1 5WW, UK.

E-mail: johnfmayberry@yahoo.co.uk

Abstract

Background

The guideline offers best practice advice on the care of adults, children and young people with Crohn's disease.

Aim

To provide clinically effective and cost-effective evidence-based recommendations to guide clinical practice in a clinical guideline commissioned by the National Institute for Health and Clinical Excellence (NICE).

Methods

A systematic review of the evidence including critical appraisal, meta-analysis and cost-effectiveness modelling.

Results

Thirty-one evidence-based recommendations covering induction and maintenance therapy are available. Five key priorities for implementation are identified together with nine future research recommendations. Three guideline versions are available: short (containing just the recommendations), full (containing the full evidence base) and an Understanding NICE guidance for patients and carers. Algorithms have been produced together with a NICE pathway and implementation tools.

Conclusion

These are the first evidence-based clinical and cost-effectiveness guidelines for Crohn's disease in the United Kingdom.

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