As part of AP&T's peer-review process, a technical check of this meta-analysis was performed by Dr Y. Yuan.
Meta-analysis: Barrett's oesophagus and the risk of colonic tumours
Article first published online: 19 NOV 2012
© 2012 Blackwell Publishing Ltd
Alimentary Pharmacology & Therapeutics
Volume 37, Issue 4, pages 401–410, February 2013
How to Cite
Andrici, J., Tio, M., Cox, M. R. and Eslick, G. D. (2013), Meta-analysis: Barrett's oesophagus and the risk of colonic tumours. Alimentary Pharmacology & Therapeutics, 37: 401–410. doi: 10.1111/apt.12146
- Issue published online: 22 JAN 2013
- Article first published online: 19 NOV 2012
- Manuscript Accepted: 27 OCT 2012
- Manuscript Revised: 8 OCT 2012
- Manuscript Revised: 5 AUG 2012
- Manuscript Received: 8 JUL 2012
Barrett's oesophagus (BO) is a premalignant condition associated with oesophageal adenocarcinoma. Although speculation exists, it is currently unclear if BO is associated with an increased risk of colonic tumours.
To conduct a meta-analysis of studies reporting the prevalence of colonic tumours in patients with BO vs. controls and thus quantify the risk of colonic tumours associated with BO.
A search was conducted through Medline, PubMed, Embase, and Current Contents Connect to 7 October 2012. We calculated pooled odds ratios (OR) and 95% confidence intervals (CI) using a random-effects model for the risk of all colonic tumours associated with BO, as well as for the subgroups of colorectal cancer (CRC) and benign adenomatous tumours.
In total, 11 studies, with 2580 BO cases, met our inclusion criteria. BO was associated with an increased risk of any colonic tumours (OR: 1.96; 95% CI: 1.56–2.46). BO was associated with an increased risk of benign adenomatous tumours (OR: 1.69; 95% CI: 1.20–2.39), as well as an increased risk of CRC (OR: 1.90; 95% CI: 1.35–2.67). No statistically significant heterogeneity was observed. Publication bias was not present.
Barrett's oesophagus was associated with an increased risk of both benign adenomatous colonic tumours and colorectal cancer. Barrett's oesophagus had a stronger association with colorectal cancer than with benign colonic tumours. Further prospective cohort studies are needed to confirm the relationship.