The prevalence of oesophageal eosinophilia and eosinophilic oesophagitis: a prospective study in unselected patients presenting to endoscopy
Article first published online: 26 FEB 2013
© 2013 Blackwell Publishing Ltd
Alimentary Pharmacology & Therapeutics
Volume 37, Issue 8, pages 825–832, April 2013
How to Cite
Aliment Pharmacol Ther 2013; 37: 825–832
- Issue published online: 18 MAR 2013
- Article first published online: 26 FEB 2013
- Manuscript Accepted: 6 FEB 2013
- Manuscript Revised: 5 FEB 2013
- Manuscript Revised: 9 OCT 2012
- Manuscript Received: 19 SEP 2012
- National Institutes of Health. Grant Number: NCI R01 116845
- Houston VA HSR&D Center of Excellence. Grant Number: HFP90-020
- Texas Digestive Disease Center. Grant Number: DK58338
- NIDDK. Grant Number: K24-04-107
Oesophageal eosinophilia (EE) is encountered in clinical practice as oesophageal biopsies are being obtained in patients with GI symptoms other than classical symptoms of eosinophilic oesophagitis (EoE). The prevalence, determinants and clinical relevance of EE identified irrespective of symptoms are unclear.
To determine the prevalence and risk factors of EE with or without EoE in a nonselected group of patients undergoing endoscopy and in primary care patients.
A cross-sectional study in a single VA centre in which we obtained at least one oesophageal biopsy from patients presenting to elective endoscopy, as well as a sample of patients eligible for screening colonoscopy recruited from primary care clinics. EE was defined by >15 eosinophils in a single HPF; and EoE was defined as definite, probable or none depending on the presence of EE, acid-suppressive therapy and oesophageal symptoms.
EE was identified in 33 of 1357 patients (2.4%, 95% CI: 1.7–3.4); of whom 9 had definite EoE (0.66%, 95% CI: 0.23–1.10), 17 had probable EoE (1.25%), and the only 7 patients had EE without EoE. The prevalence of EE was 2.3% among patients undergoing elective endoscopy and 0.1% among patients eligible for screening colonoscopy. Seasonal allergies (adjusted OR: 2.78; 95% CI: 1.26–6.11) and oesophageal strictures (4.50; 0.90–22.40) were associated with EE.
The prevalence of EE was 2.3% among unselected patients presenting to endoscopy most of whom have EoE. EE was present in 0.1% in primary care patients none of whom had EoE.