The association between serological and dietary vitamin D levels and hepatitis C-related liver disease risk differs in African American and white males
Article first published online: 26 MAY 2013
© Published 2013. This article is a US Government work and is in the public domain in the USA.
Alimentary Pharmacology & Therapeutics
Volume 38, Issue 1, pages 28–37, July 2013
How to Cite
White, D. L., Tavakoli-Tabasi, S., Kanwal, F., Ramsey, D. J., Hashmi, A., Kuzniarek, J., Patel, P., Francis, J. and El-Serag, H. B. (2013), The association between serological and dietary vitamin D levels and hepatitis C-related liver disease risk differs in African American and white males. Alimentary Pharmacology & Therapeutics, 38: 28–37. doi: 10.1111/apt.12341
- Issue published online: 6 JUN 2013
- Article first published online: 26 MAY 2013
- Manuscript Accepted: 1 MAY 2013
- Manuscript Revised: 11 APR 2013
- Manuscript Revised: 2 APR 2013
- Manuscript Received: 19 MAR 2013
- Clinical Research and Development Merit Review Award. Grant Number: H-22934
- NIH/National Institute of Diabetes and Digestive and Kidney Diseases. Grant Numbers: K24 DK081736-01, K01 DK078154-03, DK56338
- Houston VA HSR&D Center of Excellence. Grant Number: HFP90-020
Vitamin D may affect the severity of HCV-related liver disease.
To examine the association between serum vitamin D levels and advanced liver disease in a multiethnic US cohort of HCV patients, and account for dietary and supplemental intake.
We measured serum 25-hydroxyvitamin D levels and used FibroSURE-ActiTest to assess hepatic pathology in a cohort of HCV-infected male veterans. We estimated and adjusted for daily intake of vitamin D from diet using a Dietary History Questionnaire, and dispensed prescriptions prior to study enrolment. We used race-stratified logistic regression analyses to evaluate the relationship between serum vitamin D levels and risk of advanced fibrosis (F3/F4–F4) and advanced inflammation (A2/A3–A3).
A total of 163 African American (AA) and 126 White non-Hispanics were studied. Overall, ~44% of AAs and 15% of Whites were vitamin D deficient (<12 ng/mL) or insufficient (12–19 ng/mL); 4% of AAs and 9% of White patients had an elevated level (>50 ng/mL). Among AAs, patients with elevated serum vitamin D levels had significantly higher odds of advanced fibrosis (OR = 12.91, P = 0.03) than those with normal levels. In contrast, AAs with insufficient or deficient levels had > two-fold excess risk of advanced inflammation (P = 0.06). Among White males there was no association between vitamin D levels and advanced fibrosis (F3/F4–F4) or inflammation (A2/A3–A3) risk.
We observed potential differences in the association between vitamin D levels and degree of HCV-related hepatic fibrosis between White and African American males. Additional research is necessary to confirm that high serum vitamin D levels may be associated with advanced fibrosis risk in African American males, and to evaluate whether racial differences exist in HCV-infected females.