As part of AP&T's peer-review process, a technical check of this meta-analysis was performed by Dr Y. Yuan. This article was accepted for publication after full peer-review.
Systematic Review with Meta-analysis
Systematic review with meta-analysis: coffee consumption and the risk of cirrhosis
Version of Record online: 25 JAN 2016
© 2016 John Wiley & Sons Ltd
Alimentary Pharmacology & Therapeutics
Volume 43, Issue 5, pages 562–574, March 2016
How to Cite
Kennedy, O. J., Roderick, P., Buchanan, R., Fallowfield, J. A., Hayes, P. C. and Parkes, J. (2016), Systematic review with meta-analysis: coffee consumption and the risk of cirrhosis. Alimentary Pharmacology & Therapeutics, 43: 562–574. doi: 10.1111/apt.13523
- Issue online: 3 FEB 2016
- Version of Record online: 25 JAN 2016
- Manuscript Accepted: 20 DEC 2015
- Manuscript Revised: 17 DEC 2015
- Manuscript Revised: 3 DEC 2015
- Manuscript Revised: 10 NOV 2015
- Manuscript Received: 27 OCT 2015
Liver cirrhosis is a large burden on global health, causing over one million deaths per year. Observational studies have reported an inverse association between coffee and cirrhosis.
To perform a systematic review and meta-analysis to characterise the relationship between coffee consumption and cirrhosis.
We searched for studies published until July 2015 that reported odds ratios, relative risks (RR) or hazard ratios for cirrhosis stratified by coffee consumption. We calculated RRs of cirrhosis for an increase in daily coffee consumption of two cups for each study and overall. We performed analyses by study design, type of cirrhosis and mortality. We assessed the risk of bias in each study and the overall quality of evidence for the effect of coffee on cirrhosis.
We identified five cohort studies and four case–control studies involving 1990 cases and 432 133 participants. We observed a dose–response in most studies and overall. The pooled RR of cirrhosis for a daily increase in coffee consumption of two cups was 0.56 (95% CI 0.44–0.68; I2 83.3%). The RR pooled from cohort studies for a daily increase of two cups was 0.58 (95% CI 0.41–0.76; I2 91.1%) and from case–control studies it was 0.52 (95% CI 0.40–0.63; I2 0.0%). The pooled RR of alcoholic cirrhosis for a daily increase of two cups was 0.62 (95% CI 0.51–0.73; I2 0%) and of death from cirrhosis it was 0.55 (95% CI 0.35–0.74; I2 90.3%).
This meta-analysis suggests that increasing coffee consumption may substantially reduce the risk of cirrhosis.