Intestinal morphology assessments of rats fed phytic acid extract from sweet potato (Ipomoea batatas) and IP6
Version of Record online: 19 DEC 2012
Copyright © 2012 The Korean Society for Cytopathology, The Korean Society for Legal Medicine, The Korean Society of Oral and Maxillofacial Pathology, The Korean Society of Pathologists, The Korean Society of Toxicological Pathology, The Korean Society of Veterinary Pathology and Wiley Publishing Asia Pty Ltd
Basic and Applied Pathology
Volume 5, Issue 4, pages 84–90, December 2012
How to Cite
Dilworth, L., Gardner, M., Asemota, H. and Omoruyi, F. (2012), Intestinal morphology assessments of rats fed phytic acid extract from sweet potato (Ipomoea batatas) and IP6. Basic and Applied Pathology, 5: 84–90. doi: 10.1111/baap.12000
- Issue online: 19 DEC 2012
- Version of Record online: 19 DEC 2012
- Manuscript Accepted: 6 SEP 2012
- Manuscript Received: 7 NOV 2011
- University of The West Indies, Mona Campus
- phytic acid;
- sweet potato
Background and aim
Zinc deficiency due to low intake or unavailability by bioactive compounds may lead to morphological changes in the intestines resulting in disruptions in gut function. This study aims to assess effects of phytic acid on gut morphology of rats.
Diets supplemented with sweet potato phytate extract were fed to Wistar rats in zinc-deficient and zinc-sufficient states for 4 weeks. Similar test animals also had diets supplemented with the commercially available sodium phytate salt (IP6) for comparison. At the end of the feeding period, body weights, feed intake and markers of intestinal function were assessed.
Acute zinc deficiency adversely affected the glycocalyx, goblet and Paneth cells within the small intestine. This may eventually lead to compromisation of the gut's immune system and further reductions in its metabolic and absorptive capacity. This was further aggravated by sweet potato phytate extract consumption. IP6 supplementation on the other hand, increased surface amplification in the jejunum resulting in increased gut transit time and more efficient absorption of nutrients.
To minimize compromisation of the gut's immune, absorptive and metabolic functions, adequate zinc supplementation is necessary especially if foods rich in phytates are included in the diet. Supplementation of the diet with IP6 seems to offset some of these effects with maximum benefits observed if the diet is properly supplemented with essential minerals.