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Figure S1

Diagnostic plots. (A) Observed (OBS) vs. population predicted concentrations (PRED). (B) OBS vs. individual predicted concentrations (IPRED). (C) conditional weighted residuals (CWRES) vs. time. (D) CWRES vs. PRED

Figure S2

Mirror plots. Observed (DV) vs. population prediction (PRED). Observed (DV) vs. individual prediction (IPRED)

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