Translation Section


Generics, chemisimilars and biosimilars: is clinical testing fit for purpose? inline image

John B. Warren

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Between subjects variability in haemoglobin and dose are not associated with the erythropoiesis-stimulating agent used to treat anaemia in dialysis: a meta-analysis inline image

Juan José Pérez-Ruixo, Mercedes Cucala-Ramos, Ester García-Gonzalo, Beatriz Del Val Romero & Neus Valveny

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Risk: benefit of treating high blood pressure in older adults inline image

Omar Mukhtar & Stephen H. D. Jackson

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Paediatric use of mycophenolate mofetil inline image

Heather J. Downing, Munir Pirmohamed, Michael W. Beresford & Rosalind L. Smyth

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Differences between opioids: pharmacological, experimental, clinical and economical perspectives inline image

Asbjørn M. Drewes, Rasmus D. Jensen, Lecia M. Nielsen, Joanne Droney, Lona L. Christrup, Lars Arendt-Nielsen, Julia Riley & Albert Dahan

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Inhaled and systemic corticosteroid response in severe asthma assessed by alveolar nitric oxide: a randomized crossover pilot study of add-on therapy inline image

Peter A. Williamson, Philip M. Short, Sriram Vaidyanathan & Brian J. Lipworth

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Safety, tolerability and pharmacokinetics of single and multiple doses of a novel sigma-1 receptor antagonist in three randomized phase I studies inline image

Montserrat Abadias, Marisol Escriche, Anna Vaqué, Mariano Sust & Gregorio Encina

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A phase 1, randomized, placebo-controlled, dose-escalation study of an anti-IL-13 monoclonal antibody in healthy subjects and mild asthmatics inline image

Peter Hodsman, Claire Ashman, Anthony Cahn, Erika De Boever, Nicholas Locantore, Adrian Serone & Isabelle Pouliquen

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Effects of manidipine vs. amlodipine on intrarenal haemodynamics in patients with arterial hypertension inline image

Christian Ott, Markus P. Schneider, Ulrike Raff, Martin Ritt, Kristina Striepe, Marco Alberici & Roland E. Schmieder

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A contrast in safety, pharmacokinetics and pharmacodynamics across age groups after a single 50 mg oral dose of the γ-secretase inhibitor avagacestat inline image

Gary Tong, Jun-Sheng Wang, Oleksandr Sverdlov, Shu-Pang Huang, Randy Slemmon, Robert Croop, Lorna Castaneda, Huidong Gu, Oi Wong, Hewei Li, Robert M. Berman, Christina Smith, Charles F. Albright & Randy Dockens

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Disease progression model in subjects with mild cognitive impairment from the Alzheimer's disease neuroimaging initiative: CSF biomarkers predict population subtypes inline image

Mahesh N. Samtani, Nandini Raghavan, Yingqi Shi, Gerald Novak, Michael Farnum, Victor Lobanov, Tim Schultz, Eric Yang, Allitia DiBernardo, Vaibhav A. Narayan & the Alzheimer's Disease Neuroimaging Initiative

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Developmental pharmacokinetics of propylene glycol in preterm and term neonates inline image

Roosmarijn F. W. De Cock, Catherijne A. J. Knibbe, Aida Kulo, Jan de Hoon, Rene Verbesselt, Meindert Danhof & Karel Allegaert

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Apple juice greatly reduces systemic exposure to atenolol inline image

Hyewon Jeon, In-Jin Jang, SeungHwan Lee, Kyoichi Ohashi, Tsutomu Kotegawa, Ichiro Ieiri, Joo-Youn Cho, Seo Hyun Yoon, Sang-Goo Shin, Kyung-Sang Yu & Kyoung Soo Lim

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The ciprofloxacin target AUC : MIC ratio is not reached in hospitalized patients with the recommended dosing regimens inline image

Michiel Haeseker, Leo Stolk, Fred Nieman, Christian Hoebe, Cees Neef, Cathrien Bruggeman & Annelies Verbon

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Pharmacokinetics and tolerability of SRT2104, a first-in-class small molecule activator of SIRT1, after single and repeated oral administration in man inline image

Ethan Hoffmann, Jeff Wald, Siva Lavu, John Roberts, Claire Beaumont, Jon Haddad, Peter Elliott, Christoph Westphal & Eric Jacobson

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Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjects inline image

Zahid Ali, Bart Laurijssens, Thor Ostenfeld, Simon McHugh, Anastasia Stylianou, Paul Scott-Stevens, Louise Hosking, Odile Dewit, Jill C. Richardson & Chao Chen

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The pharmacokinetics and pharmacodynamics of single dose (R)- and (S)-warfarin administered separately and together: relationship to VKORC1 genotype inline image

John Maddison, Andrew A. Somogyi, Berit P. Jensen, Heather M. James, Melanie Gentgall & Paul E. Rolan

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Impact of the CYP2C8 *3 polymorphism on the drug–drug interaction between gemfibrozil and pioglitazone inline image

Christina L. Aquilante, Lisa A. Kosmiski, David W. A. Bourne, Lane R. Bushman, Elizabeth B. Daily, Kyle P. Hammond, Charles W. Hopley, Rajendra S. Kadam, Alexander T. Kanack, Uday B. Kompella, Merry Le, Julie A. Predhomme, Joseph E. Rower & Maha S. Sidhom

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Patterns of toxicity and factors influencing severity in acute adult trimipramine poisoning inline image

Karen Gutscher, Christine Rauber-Lüthy, Marina Haller, Michèle Braun, Hugo Kupferschmidt, Gerd A. Kullak-Ublick & Alessandro Ceschi

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Regional differences in symptomatic fever management among paediatricians in Switzerland: the results of a cross-sectional Web-based survey inline image

Sebastiano A. G. Lava, Giacomo D. Simonetti, Alessandra Ferrarini, Gian Paolo Ramelli & Mario G. Bianchetti

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Effects of clopidogrel and itraconazole on the disposition of efavirenz and its hydroxyl metabolites: exploration of a novel CYP2B6 phenotyping index inline image

Fen Jiang, Zeruesenay Desta, Ji-Hong Shon, Chang-Woo Yeo, Ho-Sook Kim, Kwang-Hyeon Liu, Soo-Kyung Bae, Sang-Seop Lee, David A. Flockhart & Jae-Gook Shin

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Pioglitazone and bladder cancer: a propensity score matched cohort study inline image

Li Wei, Thomas M. MacDonald & Isla S. Mackenzie

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The risk of adverse outcomes in association with use of testosterone products: a cohort study using the UK-based general practice research database inline image

Susan S. Jick & Katrina Wilcox Hagberg

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