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Figure S1

Observed vs. individual prediction. Values are indicated by open circles. The line of identity (dashed black) is included as a reference

Figure S2

Observed vs. population prediction. Values are indicated by open circles. The line of identity (dashed black) is included as a reference

Figure S3

Observed vs. individual prediction, in log scale. Values are indicated by open circles. The line of identity (dashed black) is included as a reference

Figure S4

Observed vs. population prediction, in log scale. Values are indicated by open circles. The line of identity (dashed black) is included as a reference.

Figure S5

Weighted residuals vs. Time. Values are indicated by open circles. A dashed line at y = 0 is included as a reference. One data point with a weighted residual of 68 excluded

FigureS6

Visual predictive check – complete study. Observed values are indicated by open circles, the observed median as red line. The predicted median is shown as solid black line and the 10th and 90th percentile as dashed black lines

Figure S7

Visual predictive check – study day 1. Observed values are indicated by open circles, the observed median as red line. The predicted median is shown as solid black line and the 10th and 90th percentile as dashed black lines

Figure S8

Visual predictive check – study day 7. Observed values are indicated by open circles, the observed median as red line. The predicted median is shown as solid black line and the 10th and 90th percentile as dashed black lines

Table S1

Model code

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