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British Journal of Clinical Pharmacology

© The British Pharmacological Society

Cover image for Vol. 70 Issue 1

July 2010

Volume 70, Issue 1

Pages 1–160

  1. Editors' view

    1. Top of page
    2. Editors' view
    3. Personal view
    4. New drug mechanisms
    5. Review
    6. Clinical trials
    7. Pharmacodynamics
    8. Pharmacokinetics
    9. Pharmacokinetic dynamic relationships
    10. Drug interactions
    11. Paediatric clinical pharmacology
    12. Drug safety
    13. Pharmacoepidemiology
    14. Short reports
    15. Letter to the editors
    16. Book review
    17. Mandarin translations section
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      Clinical pharmacology: a declaration of intent (pages 1–2)

      A. Somogyi, Y. K. Loke, A. Ferro, L. D. Lewis, A. F. Cohen and J. M. Ritter

      Article first published online: 11 JUN 2010 | DOI: 10.1111/j.1365-2125.2010.03706.x

  2. Personal view

    1. Top of page
    2. Editors' view
    3. Personal view
    4. New drug mechanisms
    5. Review
    6. Clinical trials
    7. Pharmacodynamics
    8. Pharmacokinetics
    9. Pharmacokinetic dynamic relationships
    10. Drug interactions
    11. Paediatric clinical pharmacology
    12. Drug safety
    13. Pharmacoepidemiology
    14. Short reports
    15. Letter to the editors
    16. Book review
    17. Mandarin translations section
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      A manifesto for clinical pharmacology from principles to practice (pages 3–13)

      Jeffrey K. Aronson

      Article first published online: 11 JUN 2010 | DOI: 10.1111/j.1365-2125.2010.03699.x

  3. New drug mechanisms

    1. Top of page
    2. Editors' view
    3. Personal view
    4. New drug mechanisms
    5. Review
    6. Clinical trials
    7. Pharmacodynamics
    8. Pharmacokinetics
    9. Pharmacokinetic dynamic relationships
    10. Drug interactions
    11. Paediatric clinical pharmacology
    12. Drug safety
    13. Pharmacoepidemiology
    14. Short reports
    15. Letter to the editors
    16. Book review
    17. Mandarin translations section
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      Dabigatran etexilate (pages 14–15)

      Eline A. Dubois and Adam F. Cohen

      Article first published online: 2 FEB 2010 | DOI: 10.1111/j.1365-2125.2010.03644.x

  4. Review

    1. Top of page
    2. Editors' view
    3. Personal view
    4. New drug mechanisms
    5. Review
    6. Clinical trials
    7. Pharmacodynamics
    8. Pharmacokinetics
    9. Pharmacokinetic dynamic relationships
    10. Drug interactions
    11. Paediatric clinical pharmacology
    12. Drug safety
    13. Pharmacoepidemiology
    14. Short reports
    15. Letter to the editors
    16. Book review
    17. Mandarin translations section
    1. You have full text access to this OnlineOpen article
      Drug- and non-drug-associated QT interval prolongation (pages 16–23)

      Charlotte Van Noord, Mark Eijgelsheim and Bruno H. Ch. Stricker

      Article first published online: 1 MAR 2010 | DOI: 10.1111/j.1365-2125.2010.03660.x

  5. Clinical trials

    1. Top of page
    2. Editors' view
    3. Personal view
    4. New drug mechanisms
    5. Review
    6. Clinical trials
    7. Pharmacodynamics
    8. Pharmacokinetics
    9. Pharmacokinetic dynamic relationships
    10. Drug interactions
    11. Paediatric clinical pharmacology
    12. Drug safety
    13. Pharmacoepidemiology
    14. Short reports
    15. Letter to the editors
    16. Book review
    17. Mandarin translations section
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      Eltrombopag does not affect cardiac repolarization: results from a definitive QTc study in healthy subjects (pages 24–33)

      Gemma Matthys, Jung Wook Park, Sandra McGuire, Mary Beth Wire, Jianping Zhang, Carolyn Bowen, Daphne Williams, Julian M. Jenkins and Bin Peng

      Article first published online: 24 FEB 2010 | DOI: 10.1111/j.1365-2125.2010.03646.x

  6. Pharmacodynamics

    1. Top of page
    2. Editors' view
    3. Personal view
    4. New drug mechanisms
    5. Review
    6. Clinical trials
    7. Pharmacodynamics
    8. Pharmacokinetics
    9. Pharmacokinetic dynamic relationships
    10. Drug interactions
    11. Paediatric clinical pharmacology
    12. Drug safety
    13. Pharmacoepidemiology
    14. Short reports
    15. Letter to the editors
    16. Book review
    17. Mandarin translations section
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      Hormonal and metabolic effects of morning or evening dosing of the dipeptidyl peptidase IV inhibitor vildagliptin in patients with type 2 diabetes (pages 34–42)

      Yan-Ling He, Jessica Valencia, Yiming Zhang, Sherwyn L. Schwartz, Monica Ligueros-Saylan, James Foley and William P. Dole

      Article first published online: 26 FEB 2010 | DOI: 10.1111/j.1365-2125.2010.03652.x

  7. Pharmacokinetics

    1. Top of page
    2. Editors' view
    3. Personal view
    4. New drug mechanisms
    5. Review
    6. Clinical trials
    7. Pharmacodynamics
    8. Pharmacokinetics
    9. Pharmacokinetic dynamic relationships
    10. Drug interactions
    11. Paediatric clinical pharmacology
    12. Drug safety
    13. Pharmacoepidemiology
    14. Short reports
    15. Letter to the editors
    16. Book review
    17. Mandarin translations section
    1. You have full text access to this OnlineOpen article
      Omeprazole preferentially inhibits the metabolism of (+)-(S)-citalopram in healthy volunteers (pages 43–51)

      Adriana Rocha, Eduardo B. Coelho, Stefânia A. Sampaio and Vera L. Lanchote

      Article first published online: 24 FEB 2010 | DOI: 10.1111/j.1365-2125.2010.03649.x

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      Can finger-prick sampling replace venous sampling to determine the pharmacokinetic profile of oral paracetamol? (pages 52–56)

      Baba S. Mohammed, Garry A. Cameron, Lindsay Cameron, Gabrielle H. Hawksworth, Peter J. Helms and James S. McLay

      Article first published online: 22 MAR 2010 | DOI: 10.1111/j.1365-2125.2010.03668.x

  8. Pharmacokinetic dynamic relationships

    1. Top of page
    2. Editors' view
    3. Personal view
    4. New drug mechanisms
    5. Review
    6. Clinical trials
    7. Pharmacodynamics
    8. Pharmacokinetics
    9. Pharmacokinetic dynamic relationships
    10. Drug interactions
    11. Paediatric clinical pharmacology
    12. Drug safety
    13. Pharmacoepidemiology
    14. Short reports
    15. Letter to the editors
    16. Book review
    17. Mandarin translations section
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      Effect of hydrochlorothiazide on the pharmacokinetics and pharmacodynamics of febuxostat, a non-purine selective inhibitor of xanthine oxidase (pages 57–64)

      Brian Grabowski, Reza Khosravan, Jing-Tao Wu, Laurent Vernillet and Christopher Lademacher

      Article first published online: 22 MAR 2010 | DOI: 10.1111/j.1365-2125.2010.03667.x

    2. You have full text access to this OnlineOpen article
      Pharmacokinetics, pharmacodynamics, safety and tolerability of multiple ascending doses of ticagrelor in healthy volunteers (pages 65–77)

      Kathleen Butler and Renli Teng

      Article first published online: 22 MAR 2010 | DOI: 10.1111/j.1365-2125.2010.03669.x

  9. Drug interactions

    1. Top of page
    2. Editors' view
    3. Personal view
    4. New drug mechanisms
    5. Review
    6. Clinical trials
    7. Pharmacodynamics
    8. Pharmacokinetics
    9. Pharmacokinetic dynamic relationships
    10. Drug interactions
    11. Paediatric clinical pharmacology
    12. Drug safety
    13. Pharmacoepidemiology
    14. Short reports
    15. Letter to the editors
    16. Book review
    17. Mandarin translations section
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      Exposure to oral oxycodone is increased by concomitant inhibition of CYP2D6 and 3A4 pathways, but not by inhibition of CYP2D6 alone (pages 78–87)

      Juha Grönlund, Teijo I. Saari, Nora M. Hagelberg, Pertti J. Neuvonen, Klaus T. Olkkola and Kari Laine

      Article first published online: 26 FEB 2010 | DOI: 10.1111/j.1365-2125.2010.03653.x

  10. Paediatric clinical pharmacology

    1. Top of page
    2. Editors' view
    3. Personal view
    4. New drug mechanisms
    5. Review
    6. Clinical trials
    7. Pharmacodynamics
    8. Pharmacokinetics
    9. Pharmacokinetic dynamic relationships
    10. Drug interactions
    11. Paediatric clinical pharmacology
    12. Drug safety
    13. Pharmacoepidemiology
    14. Short reports
    15. Letter to the editors
    16. Book review
    17. Mandarin translations section
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      Population pharmacokinetics of tamsulosin hydrochloride in paediatric patients with neuropathic and non-neuropathic bladder (pages 88–101)

      Yasuhiro Tsuda, Shinji Tatami, Norio Yamamura, Yusuke Tadayasu, Akiko Sarashina, Karl-Heinz Liesenfeld, Alexander Staab, Hans-Günter Schäfer, Ichiro Ieiri and Shun Higuchi

      Article first published online: 9 MAR 2010 | DOI: 10.1111/j.1365-2125.2010.03662.x

  11. Drug safety

    1. Top of page
    2. Editors' view
    3. Personal view
    4. New drug mechanisms
    5. Review
    6. Clinical trials
    7. Pharmacodynamics
    8. Pharmacokinetics
    9. Pharmacokinetic dynamic relationships
    10. Drug interactions
    11. Paediatric clinical pharmacology
    12. Drug safety
    13. Pharmacoepidemiology
    14. Short reports
    15. Letter to the editors
    16. Book review
    17. Mandarin translations section
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      Interpreting adverse drug reaction (ADR) reports as hospital patient safety incidents (pages 102–108)

      Emma C. Davies, Christopher F. Green, David R. Mottram and Munir Pirmohamed

      Article first published online: 22 MAR 2010 | DOI: 10.1111/j.1365-2125.2010.03671.x

  12. Pharmacoepidemiology

    1. Top of page
    2. Editors' view
    3. Personal view
    4. New drug mechanisms
    5. Review
    6. Clinical trials
    7. Pharmacodynamics
    8. Pharmacokinetics
    9. Pharmacokinetic dynamic relationships
    10. Drug interactions
    11. Paediatric clinical pharmacology
    12. Drug safety
    13. Pharmacoepidemiology
    14. Short reports
    15. Letter to the editors
    16. Book review
    17. Mandarin translations section
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      Oversight: a retrospective study of biochemical monitoring in patients beginning antihypertensive drug treatment in primary care (pages 109–117)

      Jamie J. Coleman, Sarah E. McDowell, Stephen J. W. Evans, Paramjit S. Gill and Robin E. Ferner

      Article first published online: 26 FEB 2010 | DOI: 10.1111/j.1365-2125.2010.03654.x

    2. You have full text access to this OnlineOpen article
      Effect of treatment guidelines on the initial management of idiopathic pulmonary fibrosis (pages 118–125)

      Jeffrey C. Munson, Maryl Kreider, Zhen Chen, Jason D. Christie and Stephen E. Kimmel

      Article first published online: 22 MAR 2010 | DOI: 10.1111/j.1365-2125.2010.03670.x

  13. Short reports

    1. Top of page
    2. Editors' view
    3. Personal view
    4. New drug mechanisms
    5. Review
    6. Clinical trials
    7. Pharmacodynamics
    8. Pharmacokinetics
    9. Pharmacokinetic dynamic relationships
    10. Drug interactions
    11. Paediatric clinical pharmacology
    12. Drug safety
    13. Pharmacoepidemiology
    14. Short reports
    15. Letter to the editors
    16. Book review
    17. Mandarin translations section
    1. You have full text access to this OnlineOpen article
      Effects of woohwangcheongsimwon suspension on the pharmacokinetics of bupropion and its active metabolite, 4-hydroxybupropion, in healthy subjects (pages 126–131)

      Hyunmi Kim, Soo Kyung Bae, Soo-Jin Park, Eon-Jeong Shim, Ho-Sook Kim, Ji-Hong Shon, Kwang-Hyeon Liu and Jae-Gook Shin

      Article first published online: 1 MAR 2010 | DOI: 10.1111/j.1365-2125.2010.03661.x

    2. You have full text access to this OnlineOpen article
      The ‘apparent clearance’ of free phenytoin in elderly vs. younger adults (pages 132–138)

      Daniel F. B. Wright and Evan J. Begg

      Article first published online: 22 MAR 2010 | DOI: 10.1111/j.1365-2125.2010.03673.x

    3. You have full text access to this OnlineOpen article
      Effect of high-dose cranberry juice on the pharmacodynamics of warfarin in patients (pages 139–142)

      Chadwick K. Mellen, Marjorie Ford and Joseph P. Rindone

      Article first published online: 22 MAR 2010 | DOI: 10.1111/j.1365-2125.2010.03674.x

    4. You have full text access to this OnlineOpen article
      Teaching of clinical pharmacology and therapeutics in UK medical schools: current status in 2009 (pages 143–148)

      Lelia O'Shaughnessy, Inam Haq, Simon Maxwell and Martin Llewelyn

      Article first published online: 22 MAR 2010 | DOI: 10.1111/j.1365-2125.2010.03665.x

  14. Letter to the editors

    1. Top of page
    2. Editors' view
    3. Personal view
    4. New drug mechanisms
    5. Review
    6. Clinical trials
    7. Pharmacodynamics
    8. Pharmacokinetics
    9. Pharmacokinetic dynamic relationships
    10. Drug interactions
    11. Paediatric clinical pharmacology
    12. Drug safety
    13. Pharmacoepidemiology
    14. Short reports
    15. Letter to the editors
    16. Book review
    17. Mandarin translations section
    1. You have full text access to this OnlineOpen article
      Palonosetron induced anaphylaxis in an adult female (pages 149–150)

      Yogendra K. Gupta, Saravana P. Shanmugam, Biswa M. Padhy and Aman Goyal

      Article first published online: 22 MAR 2010 | DOI: 10.1111/j.1365-2125.2010.03666.x

  15. Book review

    1. Top of page
    2. Editors' view
    3. Personal view
    4. New drug mechanisms
    5. Review
    6. Clinical trials
    7. Pharmacodynamics
    8. Pharmacokinetics
    9. Pharmacokinetic dynamic relationships
    10. Drug interactions
    11. Paediatric clinical pharmacology
    12. Drug safety
    13. Pharmacoepidemiology
    14. Short reports
    15. Letter to the editors
    16. Book review
    17. Mandarin translations section
    1. You have full text access to this OnlineOpen article
      Biomarkers in Drug Development: A Handbook of Practice, Application and Strategy (pages 151–152)

      Diane K. Jorkasky

      Article first published online: 22 MAR 2010 | DOI: 10.1111/j.1365-2125.2010.03664.x

  16. Mandarin translations section

    1. Top of page
    2. Editors' view
    3. Personal view
    4. New drug mechanisms
    5. Review
    6. Clinical trials
    7. Pharmacodynamics
    8. Pharmacokinetics
    9. Pharmacokinetic dynamic relationships
    10. Drug interactions
    11. Paediatric clinical pharmacology
    12. Drug safety
    13. Pharmacoepidemiology
    14. Short reports
    15. Letter to the editors
    16. Book review
    17. Mandarin translations section
    1. You have free access to this content
      Translation Section (pages 153–160)

      Article first published online: 11 JUN 2010 | DOI: 10.1111/j.1365-2125.2010.03707.x

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