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British Journal of Clinical Pharmacology

© The British Pharmacological Society

Cover image for Vol. 73 Issue 2

February 2012

Volume 73, Issue 2

Pages 159–330

  1. Editors' report

    1. Top of page
    2. Editors' report
    3. Commentary
    4. Viewpoint
    5. Reviews
    6. Education
    7. Clinical trials
    8. Translational research
    9. Pharmacokinetics
    10. Pharmacokinetic dynamic relationships
    11. Drug interactions
    12. Drug metabolism
    13. Human toxicology
    14. Paediatric clinical pharmacology
    15. Short report
    16. Letters to the editors
    17. Book reviews
    18. Abstracts
    19. Mandarin translations section
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      Editors' report, November 2011 (pages 159–160)

      Andrew A. Somogyi, Lionel D. Lewis, Adam F. Cohen, Albert Ferro, Yoon K. Loke and James M. Ritter

      Article first published online: 6 JAN 2012 | DOI: 10.1111/j.1365-2125.2011.04148.x

  2. Commentary

    1. Top of page
    2. Editors' report
    3. Commentary
    4. Viewpoint
    5. Reviews
    6. Education
    7. Clinical trials
    8. Translational research
    9. Pharmacokinetics
    10. Pharmacokinetic dynamic relationships
    11. Drug interactions
    12. Drug metabolism
    13. Human toxicology
    14. Paediatric clinical pharmacology
    15. Short report
    16. Letters to the editors
    17. Book reviews
    18. Abstracts
    19. Mandarin translations section
    1. You have full text access to this OnlineOpen article
      What do clinical pharmacologists do? A questionnaire survey of senior UK clinical pharmacologists (pages 161–169)

      Jeffrey K. Aronson

      Article first published online: 6 JAN 2012 | DOI: 10.1111/j.1365-2125.2011.04079.x

  3. Viewpoint

    1. Top of page
    2. Editors' report
    3. Commentary
    4. Viewpoint
    5. Reviews
    6. Education
    7. Clinical trials
    8. Translational research
    9. Pharmacokinetics
    10. Pharmacokinetic dynamic relationships
    11. Drug interactions
    12. Drug metabolism
    13. Human toxicology
    14. Paediatric clinical pharmacology
    15. Short report
    16. Letters to the editors
    17. Book reviews
    18. Abstracts
    19. Mandarin translations section
    1. You have full text access to this OnlineOpen article
      Kava hepatotoxicity in traditional and modern use: the presumed Pacific kava paradox hypothesis revisited (pages 170–174)

      Rolf Teschke, Jerome Sarris and Isaac Schweitzer

      Article first published online: 6 JAN 2012 | DOI: 10.1111/j.1365-2125.2011.04070.x

  4. Reviews

    1. Top of page
    2. Editors' report
    3. Commentary
    4. Viewpoint
    5. Reviews
    6. Education
    7. Clinical trials
    8. Translational research
    9. Pharmacokinetics
    10. Pharmacokinetic dynamic relationships
    11. Drug interactions
    12. Drug metabolism
    13. Human toxicology
    14. Paediatric clinical pharmacology
    15. Short report
    16. Letters to the editors
    17. Book reviews
    18. Abstracts
    19. Mandarin translations section
    1. You have full text access to this OnlineOpen article
      Positron emission tomography molecular imaging for drug development (pages 175–186)

      Paul M. Matthews, Eugenii A. Rabiner, Jan Passchier and Roger N. Gunn

      Article first published online: 6 JAN 2012 | DOI: 10.1111/j.1365-2125.2011.04085.x

    2. You have full text access to this OnlineOpen article
      Pre-hypertension: how low to go and do drugs have a role? (pages 187–193)

      Gordon McInnes

      Article first published online: 6 JAN 2012 | DOI: 10.1111/j.1365-2125.2011.04092.x

  5. Education

    1. Top of page
    2. Editors' report
    3. Commentary
    4. Viewpoint
    5. Reviews
    6. Education
    7. Clinical trials
    8. Translational research
    9. Pharmacokinetics
    10. Pharmacokinetic dynamic relationships
    11. Drug interactions
    12. Drug metabolism
    13. Human toxicology
    14. Paediatric clinical pharmacology
    15. Short report
    16. Letters to the editors
    17. Book reviews
    18. Abstracts
    19. Mandarin translations section
    1. You have full text access to this OnlineOpen article
      Junior doctors prescribing: enhancing their learning in practice (pages 194–202)

      Charlotte Rothwell, Bryan Burford, Jill Morrison, Gill Morrow, Maggie Allen, Carol Davies, Beate Baldauf, John Spencer, Neil Johnson, Ed Peile and Jan Illing

      Article first published online: 6 JAN 2012 | DOI: 10.1111/j.1365-2125.2011.04061.x

  6. Clinical trials

    1. Top of page
    2. Editors' report
    3. Commentary
    4. Viewpoint
    5. Reviews
    6. Education
    7. Clinical trials
    8. Translational research
    9. Pharmacokinetics
    10. Pharmacokinetic dynamic relationships
    11. Drug interactions
    12. Drug metabolism
    13. Human toxicology
    14. Paediatric clinical pharmacology
    15. Short report
    16. Letters to the editors
    17. Book reviews
    18. Abstracts
    19. Mandarin translations section
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      Assessment of the cardiac safety of prucalopride in healthy volunteers: a randomized, double-blind, placebo- and positive-controlled thorough QT study (pages 203–209)

      Boaz Mendzelevski, Jannie Ausma, Dennis O. Chanter, Patricia Robinson, Rene Kerstens, Lieve Vandeplassche and John Camm

      Article first published online: 6 JAN 2012 | DOI: 10.1111/j.1365-2125.2011.04088.x

    2. You have full text access to this OnlineOpen article
      Single dose pharmacokinetics, pharmacodynamics, tolerability and safety of BAY 60–5521, a potent inhibitor of cholesteryl ester transfer protein (pages 210–218)

      Michael-Friedrich Boettcher, Roland Heinig, Carsten Schmeck, Christian Kohlsdorfer, Matthias Ludwig, Anja Schaefer, Sabine Gelfert-Peukert, Georg Wensing and Olaf Weber

      Article first published online: 6 JAN 2012 | DOI: 10.1111/j.1365-2125.2011.04083.x

  7. Translational research

    1. Top of page
    2. Editors' report
    3. Commentary
    4. Viewpoint
    5. Reviews
    6. Education
    7. Clinical trials
    8. Translational research
    9. Pharmacokinetics
    10. Pharmacokinetic dynamic relationships
    11. Drug interactions
    12. Drug metabolism
    13. Human toxicology
    14. Paediatric clinical pharmacology
    15. Short report
    16. Letters to the editors
    17. Book reviews
    18. Abstracts
    19. Mandarin translations section
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      Prediction of a potentially effective dose in humans for BAY 60–5521, a potent inhibitor of cholesteryl ester transfer protein (CETP) by allometric species scaling and combined pharmacodynamic and physiologically-based pharmacokinetic modelling (pages 219–231)

      Olaf Weber, Stefan Willmann, Hilmar Bischoff, Volkhart Li, Alexandros Vakalopoulos, Klemens Lustig, Frank-Thorsten Hafner, Roland Heinig, Carsten Schmeck and Klaus Buehner

      Article first published online: 6 JAN 2012 | DOI: 10.1111/j.1365-2125.2011.04064.x

  8. Pharmacokinetics

    1. Top of page
    2. Editors' report
    3. Commentary
    4. Viewpoint
    5. Reviews
    6. Education
    7. Clinical trials
    8. Translational research
    9. Pharmacokinetics
    10. Pharmacokinetic dynamic relationships
    11. Drug interactions
    12. Drug metabolism
    13. Human toxicology
    14. Paediatric clinical pharmacology
    15. Short report
    16. Letters to the editors
    17. Book reviews
    18. Abstracts
    19. Mandarin translations section
    1. You have full text access to this OnlineOpen article
      Pharmacokinetics, adverse effects and tolerability of a novel analogue of human pancreatic polypeptide, PP 1420 (pages 232–239)

      Tricia M. Tan, Benjamin C. T. Field, James S. Minnion, Joyceline Cuenco-Shillito, Edward S. Chambers, Sagen Zac-Varghese, Charlie J. Brindley, Shahrul Mt-Isa, Francesca Fiorentino, Deborah Ashby, Ian Ward, Mohammad A. Ghatei and Stephen R. Bloom

      Article first published online: 6 JAN 2012 | DOI: 10.1111/j.1365-2125.2011.04082.x

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      Dosing algorithm to target a predefined AUC in patients with primary central nervous system lymphoma receiving high dose methotrexate (pages 240–247)

      Markus Joerger, Andrés J. M. Ferreri, Stephan Krähenbühl, Jan H. M. Schellens, Thomas Cerny, Emanuele Zucca and Alwin D. R. Huitema

      Article first published online: 6 JAN 2012 | DOI: 10.1111/j.1365-2125.2011.04084.x

  9. Pharmacokinetic dynamic relationships

    1. Top of page
    2. Editors' report
    3. Commentary
    4. Viewpoint
    5. Reviews
    6. Education
    7. Clinical trials
    8. Translational research
    9. Pharmacokinetics
    10. Pharmacokinetic dynamic relationships
    11. Drug interactions
    12. Drug metabolism
    13. Human toxicology
    14. Paediatric clinical pharmacology
    15. Short report
    16. Letters to the editors
    17. Book reviews
    18. Abstracts
    19. Mandarin translations section
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      Prediction and evaluation of fetal toxicity induced by NSAIDs using transplacental kinetic parameters obtained from human placental perfusion studies (pages 248–256)

      Kyohei Shintaku, Satoko Hori, Hiroki Satoh, Kiyomi Tsukimori, Hitoo Nakano, Tomoyuki Fujii, Yuji Taketani, Hisakazu Ohtani and Yasufumi Sawada

      Article first published online: 6 JAN 2012 | DOI: 10.1111/j.1365-2125.2011.03921.x

  10. Drug interactions

    1. Top of page
    2. Editors' report
    3. Commentary
    4. Viewpoint
    5. Reviews
    6. Education
    7. Clinical trials
    8. Translational research
    9. Pharmacokinetics
    10. Pharmacokinetic dynamic relationships
    11. Drug interactions
    12. Drug metabolism
    13. Human toxicology
    14. Paediatric clinical pharmacology
    15. Short report
    16. Letters to the editors
    17. Book reviews
    18. Abstracts
    19. Mandarin translations section
    1. You have full text access to this OnlineOpen article
      CYP2C8 but not CYP3A4 is important in the pharmacokinetics of montelukast (pages 257–267)

      Tiina Karonen, Pertti J. Neuvonen and Janne T. Backman

      Article first published online: 6 JAN 2012 | DOI: 10.1111/j.1365-2125.2011.04086.x

  11. Drug metabolism

    1. Top of page
    2. Editors' report
    3. Commentary
    4. Viewpoint
    5. Reviews
    6. Education
    7. Clinical trials
    8. Translational research
    9. Pharmacokinetics
    10. Pharmacokinetic dynamic relationships
    11. Drug interactions
    12. Drug metabolism
    13. Human toxicology
    14. Paediatric clinical pharmacology
    15. Short report
    16. Letters to the editors
    17. Book reviews
    18. Abstracts
    19. Mandarin translations section
    1. You have full text access to this OnlineOpen article
      Metabolic capabilities of cytochrome P450 enzymes in Chinese liver microsomes compared with those in Caucasian liver microsomes (pages 268–284)

      Junling Yang, Minxia M. He, Wei Niu, Steven A. Wrighton, Li Li, Yang Liu and Chuan Li

      Article first published online: 6 JAN 2012 | DOI: 10.1111/j.1365-2125.2011.04076.x

  12. Human toxicology

    1. Top of page
    2. Editors' report
    3. Commentary
    4. Viewpoint
    5. Reviews
    6. Education
    7. Clinical trials
    8. Translational research
    9. Pharmacokinetics
    10. Pharmacokinetic dynamic relationships
    11. Drug interactions
    12. Drug metabolism
    13. Human toxicology
    14. Paediatric clinical pharmacology
    15. Short report
    16. Letters to the editors
    17. Book reviews
    18. Abstracts
    19. Mandarin translations section
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      Staggered overdose pattern and delay to hospital presentation are associated with adverse outcomes following paracetamol-induced hepatotoxicity (pages 285–294)

      Darren G. N. Craig, Caroline M. Bates, Janice S. Davidson, Kirsty G. Martin, Peter C. Hayes and Kenneth J. Simpson

      Article first published online: 6 JAN 2012 | DOI: 10.1111/j.1365-2125.2011.04067.x

  13. Paediatric clinical pharmacology

    1. Top of page
    2. Editors' report
    3. Commentary
    4. Viewpoint
    5. Reviews
    6. Education
    7. Clinical trials
    8. Translational research
    9. Pharmacokinetics
    10. Pharmacokinetic dynamic relationships
    11. Drug interactions
    12. Drug metabolism
    13. Human toxicology
    14. Paediatric clinical pharmacology
    15. Short report
    16. Letters to the editors
    17. Book reviews
    18. Abstracts
    19. Mandarin translations section
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      Clomipramine concentration and withdrawal symptoms in 10 neonates (pages 295–302)

      Peter G. J. ter Horst, Susanne van der Linde, Jan Pieter Smit, Jan den Boon, Richard A. van Lingen, Frank G. A. Jansman, Lolkje T. W. De Jong-van den Berg and Bob Wilffert

      Article first published online: 6 JAN 2012 | DOI: 10.1111/j.1365-2125.2011.04072.x

  14. Short report

    1. Top of page
    2. Editors' report
    3. Commentary
    4. Viewpoint
    5. Reviews
    6. Education
    7. Clinical trials
    8. Translational research
    9. Pharmacokinetics
    10. Pharmacokinetic dynamic relationships
    11. Drug interactions
    12. Drug metabolism
    13. Human toxicology
    14. Paediatric clinical pharmacology
    15. Short report
    16. Letters to the editors
    17. Book reviews
    18. Abstracts
    19. Mandarin translations section
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      The effects of a single nucleotide polymorphism in SLCO1B1 on the pharmacodynamics of pravastatin (pages 303–306)

      Nicholas G. Martin, Ka Wah Li, Heather Murray, Wendy Putt, Chris J. Packard and Steve E. Humphries

      Article first published online: 6 JAN 2012 | DOI: 10.1111/j.1365-2125.2011.04090.x

  15. Letters to the editors

    1. Top of page
    2. Editors' report
    3. Commentary
    4. Viewpoint
    5. Reviews
    6. Education
    7. Clinical trials
    8. Translational research
    9. Pharmacokinetics
    10. Pharmacokinetic dynamic relationships
    11. Drug interactions
    12. Drug metabolism
    13. Human toxicology
    14. Paediatric clinical pharmacology
    15. Short report
    16. Letters to the editors
    17. Book reviews
    18. Abstracts
    19. Mandarin translations section
    1. You have full text access to this OnlineOpen article
      Unlicensed use of metformin in children and adolescents in Germany and France (pages 307–308)

      Karel Kostev and Hartmut Richter

      Article first published online: 6 JAN 2012 | DOI: 10.1111/j.1365-2125.2011.04099.x

    2. You have full text access to this OnlineOpen article
      Time for clinical trials of epigenetic drugs in psychiatric disorders? (pages 309–310)

      Jacob Peedicayil and Aniket Kumar

      Article first published online: 6 JAN 2012 | DOI: 10.1111/j.1365-2125.2011.04100.x

  16. Book reviews

    1. Top of page
    2. Editors' report
    3. Commentary
    4. Viewpoint
    5. Reviews
    6. Education
    7. Clinical trials
    8. Translational research
    9. Pharmacokinetics
    10. Pharmacokinetic dynamic relationships
    11. Drug interactions
    12. Drug metabolism
    13. Human toxicology
    14. Paediatric clinical pharmacology
    15. Short report
    16. Letters to the editors
    17. Book reviews
    18. Abstracts
    19. Mandarin translations section
    1. You have full text access to this OnlineOpen article
      Atlas of Implantable Therapies for Pain Management (page 311)

      Nicholas Padfield

      Article first published online: 6 JAN 2012 | DOI: 10.1111/j.1365-2125.2011.04057.x

    2. You have full text access to this OnlineOpen article
      Basic Pharmacokinetics and Pharmacodynamics, an Integrated Textbook and Computer Simulations (pages 312–313)

      Stephen Duffull

      Article first published online: 6 JAN 2012 | DOI: 10.1111/j.1365-2125.2011.04077.x

  17. Abstracts

    1. Top of page
    2. Editors' report
    3. Commentary
    4. Viewpoint
    5. Reviews
    6. Education
    7. Clinical trials
    8. Translational research
    9. Pharmacokinetics
    10. Pharmacokinetic dynamic relationships
    11. Drug interactions
    12. Drug metabolism
    13. Human toxicology
    14. Paediatric clinical pharmacology
    15. Short report
    16. Letters to the editors
    17. Book reviews
    18. Abstracts
    19. Mandarin translations section
    1. You have full text access to this OnlineOpen article
      ABSTRACTS OF THE DUTCH SOCIETY OF CLINICAL PHARMACOLOGY AND BIOPHARMACY MEETING OF APRIL 2011 (pages 314–321)

      Article first published online: 6 JAN 2012 | DOI: 10.1111/j.1365-2125.2011.04069.x

  18. Mandarin translations section

    1. Top of page
    2. Editors' report
    3. Commentary
    4. Viewpoint
    5. Reviews
    6. Education
    7. Clinical trials
    8. Translational research
    9. Pharmacokinetics
    10. Pharmacokinetic dynamic relationships
    11. Drug interactions
    12. Drug metabolism
    13. Human toxicology
    14. Paediatric clinical pharmacology
    15. Short report
    16. Letters to the editors
    17. Book reviews
    18. Abstracts
    19. Mandarin translations section
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      Translation Section (pages 322–330)

      Article first published online: 6 JAN 2012 | DOI: 10.1111/j.1365-2125.2011.04162.x

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