British Journal of Clinical Pharmacology

© The British Pharmacological Society

Cover image for Vol. 74 Issue 6

December 2012

Volume 74, Issue 6

Pages 903–1080

  1. Editors' view

    1. Top of page
    2. Editors' view
    3. Commentary
    4. Reviews
    5. Clinical trials
    6. Pharmacodynamics
    7. Pharmacokinetics
    8. Pharmacokinetic dynamic relationships
    9. Drug interactions
    10. Pharmacogenetics
    11. Methods in clinical pharmacology
    12. Drug safety
    13. Drugs in pregnancy and lactation
    14. Short report
    15. Letters to the editors
    16. Mandarin translations section
    1. You have free access to this content
      Industrialized research in the BJCP: A neo-Luddite view (pages 903–906)

      Adam F. Cohen and James M. Ritter

      Article first published online: 13 NOV 2012 | DOI: 10.1111/bcp.12000

  2. Commentary

    1. Top of page
    2. Editors' view
    3. Commentary
    4. Reviews
    5. Clinical trials
    6. Pharmacodynamics
    7. Pharmacokinetics
    8. Pharmacokinetic dynamic relationships
    9. Drug interactions
    10. Pharmacogenetics
    11. Methods in clinical pharmacology
    12. Drug safety
    13. Drugs in pregnancy and lactation
    14. Short report
    15. Letters to the editors
    16. Mandarin translations section
    1. The clofibrate saga: a retrospective commentary (pages 907–910)

      Michael Oliver

      Article first published online: 13 NOV 2012 | DOI: 10.1111/j.1365-2125.2012.04282.x

  3. Reviews

    1. Top of page
    2. Editors' view
    3. Commentary
    4. Reviews
    5. Clinical trials
    6. Pharmacodynamics
    7. Pharmacokinetics
    8. Pharmacokinetic dynamic relationships
    9. Drug interactions
    10. Pharmacogenetics
    11. Methods in clinical pharmacology
    12. Drug safety
    13. Drugs in pregnancy and lactation
    14. Short report
    15. Letters to the editors
    16. Mandarin translations section
    1. Gut hormones: the future of obesity treatment? (pages 911–919)

      Anne K. McGavigan and Kevin G. Murphy

      Article first published online: 13 NOV 2012 | DOI: 10.1111/j.1365-2125.2012.04278.x

    2. A European approach to categorizing medicines for fitness to drive: outcomes of the DRUID project (pages 920–931)

      Silvia Ravera, Susana P. Monteiro, Johan Jacob de Gier, Trudy van der Linden, Trinidad Gómez-Talegón and F. Javier Álvarez, the DRUID Project WP4 Partners

      Article first published online: 13 NOV 2012 | DOI: 10.1111/j.1365-2125.2012.04279.x

    3. You have full text access to this OnlineOpen article
      The status of pharmacometrics in pregnancy: highlights from the 3rd American conference on pharmacometrics (pages 932–939)

      J. G. Coen van Hasselt, Marilee A. Andrew, Mary F. Hebert, Joel Tarning, Paolo Vicini and Donald R. Mattison

      Article first published online: 13 NOV 2012 | DOI: 10.1111/j.1365-2125.2012.04280.x

  4. Clinical trials

    1. Top of page
    2. Editors' view
    3. Commentary
    4. Reviews
    5. Clinical trials
    6. Pharmacodynamics
    7. Pharmacokinetics
    8. Pharmacokinetic dynamic relationships
    9. Drug interactions
    10. Pharmacogenetics
    11. Methods in clinical pharmacology
    12. Drug safety
    13. Drugs in pregnancy and lactation
    14. Short report
    15. Letters to the editors
    16. Mandarin translations section
    1. Intravitreal pegaptanib sodium (Macugen®) for treatment of diabetic macular oedema: a morphologic and functional study (pages 940–946)

      Michele Rinaldi, Flavia Chiosi, Roberto dell'Omo, Mario R. Romano, Francesco Parmeggiani, Francesco Semeraro, Rodolfo Mastropasqua and Ciro Costagliola

      Article first published online: 13 NOV 2012 | DOI: 10.1111/j.1365-2125.2012.04291.x

    2. Efficacy and safety of venous thromboembolism prophylaxis with fondaparinux or low molecular weight heparin in a large cohort of consecutive patients undergoing major orthopaedic surgery – findings from the ORTHO-TEP registry (pages 947–958)

      Lars Donath, Jörg Lützner, Sebastian Werth, Eberhard Kuhlisch, Albrecht Hartmann, Klaus-Peter Günther, Norbert Weiss and Jan Beyer-Westendorf

      Article first published online: 13 NOV 2012 | DOI: 10.1111/j.1365-2125.2012.04302.x

  5. Pharmacodynamics

    1. Top of page
    2. Editors' view
    3. Commentary
    4. Reviews
    5. Clinical trials
    6. Pharmacodynamics
    7. Pharmacokinetics
    8. Pharmacokinetic dynamic relationships
    9. Drug interactions
    10. Pharmacogenetics
    11. Methods in clinical pharmacology
    12. Drug safety
    13. Drugs in pregnancy and lactation
    14. Short report
    15. Letters to the editors
    16. Mandarin translations section
    1. Serum and urine bone resorption markers and pharmacokinetics of the cathepsin K inhibitor ONO-5334 after ascending single doses in post menopausal women (pages 959–970)

      Shinichi Nagase, Yoshitaka Hashimoto, Maria Small, Michiyo Ohyama, Tomohiro Kuwayama and Steve Deacon

      Article first published online: 13 NOV 2012 | DOI: 10.1111/j.1365-2125.2012.04307.x

  6. Pharmacokinetics

    1. Top of page
    2. Editors' view
    3. Commentary
    4. Reviews
    5. Clinical trials
    6. Pharmacodynamics
    7. Pharmacokinetics
    8. Pharmacokinetic dynamic relationships
    9. Drug interactions
    10. Pharmacogenetics
    11. Methods in clinical pharmacology
    12. Drug safety
    13. Drugs in pregnancy and lactation
    14. Short report
    15. Letters to the editors
    16. Mandarin translations section
    1. Population pharmacokinetics of clindamycin orally and intravenously administered in patients with osteomyelitis (pages 971–977)

      Naïm Bouazza, Vincent Pestre, Vincent Jullien, Emmanuel Curis, Saïk Urien, Dominique Salmon and Jean-Marc Tréluyer

      Article first published online: 13 NOV 2012 | DOI: 10.1111/j.1365-2125.2012.04292.x

  7. Pharmacokinetic dynamic relationships

    1. Top of page
    2. Editors' view
    3. Commentary
    4. Reviews
    5. Clinical trials
    6. Pharmacodynamics
    7. Pharmacokinetics
    8. Pharmacokinetic dynamic relationships
    9. Drug interactions
    10. Pharmacogenetics
    11. Methods in clinical pharmacology
    12. Drug safety
    13. Drugs in pregnancy and lactation
    14. Short report
    15. Letters to the editors
    16. Mandarin translations section
    1. Integrated pharmacokinetics and pharmacodynamics of epoprostenol in healthy subjects (pages 978–989)

      Laurent B. Nicolas, Andreas Krause, Marcelo M. Gutierrez and Jasper Dingemanse

      Article first published online: 13 NOV 2012 | DOI: 10.1111/j.1365-2125.2012.04301.x

    2. Acute haemodynamic response in relation to plasma vardenafil concentrations in patients with pulmonary hypertension (pages 990–998)

      Dan Henrohn, Anna Sandqvist, Mikael Hedeland, Hanna Egeröd, Ulf Bondesson and Gerhard Wikström

      Article first published online: 13 NOV 2012 | DOI: 10.1111/j.1365-2125.2012.04303.x

  8. Drug interactions

    1. Top of page
    2. Editors' view
    3. Commentary
    4. Reviews
    5. Clinical trials
    6. Pharmacodynamics
    7. Pharmacokinetics
    8. Pharmacokinetic dynamic relationships
    9. Drug interactions
    10. Pharmacogenetics
    11. Methods in clinical pharmacology
    12. Drug safety
    13. Drugs in pregnancy and lactation
    14. Short report
    15. Letters to the editors
    16. Mandarin translations section
    1. Rapid clinical induction of bupropion hydroxylation by metamizole in healthy Chinese men (pages 999–1004)

      Wen-Jie Qin, Wei Zhang, Zhao-Qian Liu, Xiao-Ping Chen, Zhi-Rong Tan, Dong-Li Hu, Dan Wang, Lan Fan and Hong-Hao Zhou

      Article first published online: 13 NOV 2012 | DOI: 10.1111/j.1365-2125.2012.04304.x

  9. Pharmacogenetics

    1. Top of page
    2. Editors' view
    3. Commentary
    4. Reviews
    5. Clinical trials
    6. Pharmacodynamics
    7. Pharmacokinetics
    8. Pharmacokinetic dynamic relationships
    9. Drug interactions
    10. Pharmacogenetics
    11. Methods in clinical pharmacology
    12. Drug safety
    13. Drugs in pregnancy and lactation
    14. Short report
    15. Letters to the editors
    16. Mandarin translations section
    1. Pharmacogenetic markers of CYP2B6 associated with efavirenz plasma concentrations in HIV-1 infected Thai adults (pages 1005–1012)

      Chonlaphat Sukasem, Tim R. Cressey, Pattamawan Prapaithong, Yardpiroon Tawon, Ekawat Pasomsub, Chutatip Srichunrusami, Thawinee Jantararoungtong, Marc Lallement and Wasun Chantratita

      Article first published online: 13 NOV 2012 | DOI: 10.1111/j.1365-2125.2012.04288.x

  10. Methods in clinical pharmacology

    1. Top of page
    2. Editors' view
    3. Commentary
    4. Reviews
    5. Clinical trials
    6. Pharmacodynamics
    7. Pharmacokinetics
    8. Pharmacokinetic dynamic relationships
    9. Drug interactions
    10. Pharmacogenetics
    11. Methods in clinical pharmacology
    12. Drug safety
    13. Drugs in pregnancy and lactation
    14. Short report
    15. Letters to the editors
    16. Mandarin translations section
    1. Quantification of the spatial distribution of rectally applied surrogates for microbicide and semen in colon with SPECT and magnetic resonance imaging (pages 1013–1022)

      Ying J. Cao, Brian S. Caffo, Edward J. Fuchs, Linda A. Lee, Yong Du, Liye Li, Rahul P. Bakshi, Katarzyna Macura, Wasif A. Khan, Richard L. Wahl, Lisa A. Grohskopf and Craig W. Hendrix

      Article first published online: 13 NOV 2012 | DOI: 10.1111/j.1365-2125.2012.04267.x

    2. Inhaled LPS challenges in smokers: a study of pulmonary and systemic effects (pages 1023–1032)

      Raminder Aul, Jane Armstrong, Annelyse Duvoix, David Lomas, Brian Hayes, Bruce E. Miller, Chris Jagger and Dave Singh

      Article first published online: 13 NOV 2012 | DOI: 10.1111/j.1365-2125.2012.04287.x

    3. Human microdose evaluation of the novel EP1 receptor antagonist GSK269984A (pages 1033–1044)

      Thor Ostenfeld, Claire Beaumont, Jonathan Bullman, Maria Beaumont and Phillip Jeffrey

      Article first published online: 13 NOV 2012 | DOI: 10.1111/j.1365-2125.2012.04296.x

  11. Drug safety

    1. Top of page
    2. Editors' view
    3. Commentary
    4. Reviews
    5. Clinical trials
    6. Pharmacodynamics
    7. Pharmacokinetics
    8. Pharmacokinetic dynamic relationships
    9. Drug interactions
    10. Pharmacogenetics
    11. Methods in clinical pharmacology
    12. Drug safety
    13. Drugs in pregnancy and lactation
    14. Short report
    15. Letters to the editors
    16. Mandarin translations section
    1. Sex differences in cardiovascular drug-induced adverse reactions causing hospital admissions (pages 1045–1052)

      Eline M. Rodenburg, Bruno H. Stricker and Loes E. Visser

      Article first published online: 13 NOV 2012 | DOI: 10.1111/j.1365-2125.2012.04310.x

  12. Drugs in pregnancy and lactation

    1. Top of page
    2. Editors' view
    3. Commentary
    4. Reviews
    5. Clinical trials
    6. Pharmacodynamics
    7. Pharmacokinetics
    8. Pharmacokinetic dynamic relationships
    9. Drug interactions
    10. Pharmacogenetics
    11. Methods in clinical pharmacology
    12. Drug safety
    13. Drugs in pregnancy and lactation
    14. Short report
    15. Letters to the editors
    16. Mandarin translations section
    1. Pregnancy outcome after gestational exposure to erythromycin – a population-based register study from Norway (pages 1053–1062)

      Maria Romøren, Morten Lindbæk and Hedvig Nordeng

      Article first published online: 13 NOV 2012 | DOI: 10.1111/j.1365-2125.2012.04286.x

  13. Short report

    1. Top of page
    2. Editors' view
    3. Commentary
    4. Reviews
    5. Clinical trials
    6. Pharmacodynamics
    7. Pharmacokinetics
    8. Pharmacokinetic dynamic relationships
    9. Drug interactions
    10. Pharmacogenetics
    11. Methods in clinical pharmacology
    12. Drug safety
    13. Drugs in pregnancy and lactation
    14. Short report
    15. Letters to the editors
    16. Mandarin translations section
    1. Should monitoring of vancomycin be delayed? A case of likely nephrotoxicity occasioned by morbid obesity and minimal monitoring (pages 1063–1065)

      Terry E. Jones, Hayley Vasileff and Cassie Hewton

      Article first published online: 13 NOV 2012 | DOI: 10.1111/j.1365-2125.2011.04006.x

  14. Letters to the editors

    1. Top of page
    2. Editors' view
    3. Commentary
    4. Reviews
    5. Clinical trials
    6. Pharmacodynamics
    7. Pharmacokinetics
    8. Pharmacokinetic dynamic relationships
    9. Drug interactions
    10. Pharmacogenetics
    11. Methods in clinical pharmacology
    12. Drug safety
    13. Drugs in pregnancy and lactation
    14. Short report
    15. Letters to the editors
    16. Mandarin translations section
    1. Paracetamol (acetaminophen) overdose and acetylcysteine administration: should the United Kingdom adopt a single ‘150-line’? (pages 1066–1067)

      W. Stephen Waring

      Article first published online: 13 NOV 2012 | DOI: 10.1111/j.1365-2125.2012.04289.x

    2. The effect of omeprazole and esomeprazole on the maintenance dose of phenprocoumon (pages 1068–1069)

      Talitha I. Verhoef, Miranda J. L. Zuurhout, Rianne M. F. van Schie, William K. Redekop, Felix J. M. van der Meer, Saskia le Cessie, Tom Schalekamp, Anthonius de Boer and Anke Hilse Maitland-van der Zee

      Article first published online: 13 NOV 2012 | DOI: 10.1111/j.1365-2125.2012.04295.x

    3. Severe efavirenz-induced vacuolar axonopathy complicated by fatal aspiration pneumonia (pages 1070–1072)

      Chris Kenyon, Sipho Mfolozi, Roland Croxford, Robert Colebunders and Karen Cohen

      Article first published online: 13 NOV 2012 | DOI: 10.1111/j.1365-2125.2012.04299.x

  15. Mandarin translations section

    1. Top of page
    2. Editors' view
    3. Commentary
    4. Reviews
    5. Clinical trials
    6. Pharmacodynamics
    7. Pharmacokinetics
    8. Pharmacokinetic dynamic relationships
    9. Drug interactions
    10. Pharmacogenetics
    11. Methods in clinical pharmacology
    12. Drug safety
    13. Drugs in pregnancy and lactation
    14. Short report
    15. Letters to the editors
    16. Mandarin translations section
    1. You have free access to this content
      Translation Section (pages 1073–1080)

      Article first published online: 13 NOV 2012 | DOI: 10.1111/bcp.12013

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