British Journal of Clinical Pharmacology

Cover image for Vol. 82 Issue 4

October 2016

Volume 82, Issue 4

Pages 895–1149

  1. ISSUE INFORMATION

    1. Top of page
    2. ISSUE INFORMATION
    3. ISSUE HIGHLIGHTS
    4. EDITORIAL
    5. SYSTEMATIC REVIEWS
    6. REVIEWS
    7. CLINICAL TRIALS
    8. PHARMACOKINETICS
    9. PHARMACOKINETIC DYNAMIC RELATIONSHIPS
    10. DRUG INTERACTIONS
    11. METHODS IN CLINICAL PHARMACOLOGY
    12. DRUG SAFETY
    13. DRUGS IN PREGNANCY AND LACTATION
    14. PHARMACOEPIDEMIOLOGY
    15. LETTER TO THE EDITOR
    1. You have free access to this content
      Issue Information (pages 895–897)

      Version of Record online: 9 SEP 2016 | DOI: 10.1111/bcp.12773

  2. ISSUE HIGHLIGHTS

    1. Top of page
    2. ISSUE INFORMATION
    3. ISSUE HIGHLIGHTS
    4. EDITORIAL
    5. SYSTEMATIC REVIEWS
    6. REVIEWS
    7. CLINICAL TRIALS
    8. PHARMACOKINETICS
    9. PHARMACOKINETIC DYNAMIC RELATIONSHIPS
    10. DRUG INTERACTIONS
    11. METHODS IN CLINICAL PHARMACOLOGY
    12. DRUG SAFETY
    13. DRUGS IN PREGNANCY AND LACTATION
    14. PHARMACOEPIDEMIOLOGY
    15. LETTER TO THE EDITOR
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      Issue Highlights (pages 898–899)

      Version of Record online: 9 SEP 2016 | DOI: 10.1111/bcp.13104

  3. EDITORIAL

    1. Top of page
    2. ISSUE INFORMATION
    3. ISSUE HIGHLIGHTS
    4. EDITORIAL
    5. SYSTEMATIC REVIEWS
    6. REVIEWS
    7. CLINICAL TRIALS
    8. PHARMACOKINETICS
    9. PHARMACOKINETIC DYNAMIC RELATIONSHIPS
    10. DRUG INTERACTIONS
    11. METHODS IN CLINICAL PHARMACOLOGY
    12. DRUG SAFETY
    13. DRUGS IN PREGNANCY AND LACTATION
    14. PHARMACOEPIDEMIOLOGY
    15. LETTER TO THE EDITOR
    1. You have free access to this content
  4. SYSTEMATIC REVIEWS

    1. Top of page
    2. ISSUE INFORMATION
    3. ISSUE HIGHLIGHTS
    4. EDITORIAL
    5. SYSTEMATIC REVIEWS
    6. REVIEWS
    7. CLINICAL TRIALS
    8. PHARMACOKINETICS
    9. PHARMACOKINETIC DYNAMIC RELATIONSHIPS
    10. DRUG INTERACTIONS
    11. METHODS IN CLINICAL PHARMACOLOGY
    12. DRUG SAFETY
    13. DRUGS IN PREGNANCY AND LACTATION
    14. PHARMACOEPIDEMIOLOGY
    15. LETTER TO THE EDITOR
    1. You have free access to this content
      A literature review on the pharmacological sensitivity of human evoked hyperalgesia pain models (pages 903–922)

      Guido van Amerongen, Matthijs W. de Boer, Geert Jan Groeneveld and Justin L. Hay

      Version of Record online: 8 JUL 2016 | DOI: 10.1111/bcp.13018

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  5. REVIEWS

    1. Top of page
    2. ISSUE INFORMATION
    3. ISSUE HIGHLIGHTS
    4. EDITORIAL
    5. SYSTEMATIC REVIEWS
    6. REVIEWS
    7. CLINICAL TRIALS
    8. PHARMACOKINETICS
    9. PHARMACOKINETIC DYNAMIC RELATIONSHIPS
    10. DRUG INTERACTIONS
    11. METHODS IN CLINICAL PHARMACOLOGY
    12. DRUG SAFETY
    13. DRUGS IN PREGNANCY AND LACTATION
    14. PHARMACOEPIDEMIOLOGY
    15. LETTER TO THE EDITOR
    1. You have full text access to this OnlineOpen article
      Palmitoylethanolamide for the treatment of pain: pharmacokinetics, safety and efficacy (pages 932–942)

      Linda Gabrielsson, Sofia Mattsson and Christopher J. Fowler

      Version of Record online: 29 JUN 2016 | DOI: 10.1111/bcp.13020

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      AKT in cancer: new molecular insights and advances in drug development (pages 943–956)

      Prabhjot S. Mundi, Jasgit Sachdev, Carolyn McCourt and Kevin Kalinsky

      Version of Record online: 27 JUN 2016 | DOI: 10.1111/bcp.13021

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    3. You have free access to this content
  6. CLINICAL TRIALS

    1. Top of page
    2. ISSUE INFORMATION
    3. ISSUE HIGHLIGHTS
    4. EDITORIAL
    5. SYSTEMATIC REVIEWS
    6. REVIEWS
    7. CLINICAL TRIALS
    8. PHARMACOKINETICS
    9. PHARMACOKINETIC DYNAMIC RELATIONSHIPS
    10. DRUG INTERACTIONS
    11. METHODS IN CLINICAL PHARMACOLOGY
    12. DRUG SAFETY
    13. DRUGS IN PREGNANCY AND LACTATION
    14. PHARMACOEPIDEMIOLOGY
    15. LETTER TO THE EDITOR
    1. You have full text access to this OnlineOpen article
      How aligned are the perspectives of EU regulators and HTA bodies? A comparative analysis of regulatory-HTA parallel scientific advice (pages 965–973)

      Giovanni Tafuri, Margherita Pagnini, Jane Moseley, Marco Massari, Frank Petavy, Antje Behring, Arantxa Catalan, Elangovan Gajraj, Niklas Hedberg, Mercè Obach, Leeza Osipenko, Pierluigi Russo, Marc Van De Casteele, Eva-Maria Zebedin, Guido Rasi and Spiros Vamvakas

      Version of Record online: 1 JUL 2016 | DOI: 10.1111/bcp.13023

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    2. You have full text access to this OnlineOpen article
      Cardiovascular effects of urocortin 2 and urocortin 3 in patients with chronic heart failure (pages 974–982)

      Colin G. Stirrat, Sowmya Venkatasubramanian, Tania Pawade, Andrew J. Mitchell, Anoop S. Shah, Ninian N. Lang and David E. Newby

      Version of Record online: 28 JUL 2016 | DOI: 10.1111/bcp.13033

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    3. You have full text access to this OnlineOpen article
      Comparison of the pharmacokinetics, safety, and immunogenicity of MSB11022, a biosimilar of adalimumab, with Humira® in healthy subjects (pages 983–993)

      Elizabeth Hyland, Tim Mant, Pantelis Vlachos, Neil Attkins, Martin Ullmann, Sanjeev Roy and Volker Wagner

      Version of Record online: 28 JUL 2016 | DOI: 10.1111/bcp.13039

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  7. PHARMACOKINETICS

    1. Top of page
    2. ISSUE INFORMATION
    3. ISSUE HIGHLIGHTS
    4. EDITORIAL
    5. SYSTEMATIC REVIEWS
    6. REVIEWS
    7. CLINICAL TRIALS
    8. PHARMACOKINETICS
    9. PHARMACOKINETIC DYNAMIC RELATIONSHIPS
    10. DRUG INTERACTIONS
    11. METHODS IN CLINICAL PHARMACOLOGY
    12. DRUG SAFETY
    13. DRUGS IN PREGNANCY AND LACTATION
    14. PHARMACOEPIDEMIOLOGY
    15. LETTER TO THE EDITOR
    1. You have full text access to this OnlineOpen article
      Effects of renal impairment on the pharmacokinetics of orally administered deferiprone (pages 994–1001)

      Caroline Fradette, Vincent Pichette, Éric Sicard, Anne Stilman, Shalini Jayashankar, Yu Chung Tsang, Michael Spino and Fernando Tricta

      Version of Record online: 18 JUL 2016 | DOI: 10.1111/bcp.13037

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      Limited sampling strategy for determining metformin area under the plasma concentration–time curve (pages 1002–1010)

      Ana Beatriz Santoro, Tore Bjerregaard Stage, Claudio José Struchiner, Mette Marie Hougaard Christensen, Kim Brosen and Guilherme Suarez-Kurtz

      Version of Record online: 24 JUL 2016 | DOI: 10.1111/bcp.13049

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  8. PHARMACOKINETIC DYNAMIC RELATIONSHIPS

    1. Top of page
    2. ISSUE INFORMATION
    3. ISSUE HIGHLIGHTS
    4. EDITORIAL
    5. SYSTEMATIC REVIEWS
    6. REVIEWS
    7. CLINICAL TRIALS
    8. PHARMACOKINETICS
    9. PHARMACOKINETIC DYNAMIC RELATIONSHIPS
    10. DRUG INTERACTIONS
    11. METHODS IN CLINICAL PHARMACOLOGY
    12. DRUG SAFETY
    13. DRUGS IN PREGNANCY AND LACTATION
    14. PHARMACOEPIDEMIOLOGY
    15. LETTER TO THE EDITOR
    1. Model-based exposure-response analysis to quantify age related differences in the response to scopolamine in healthy subjects (pages 1011–1021)

      Ricardo Alvarez-Jimenez, Geert Jan Groeneveld, Joop M. A. van Gerven, Sebastiaan C. Goulooze, Anne Catrien Baakman, Justin L. Hay and Jasper Stevens

      Version of Record online: 14 JUL 2016 | DOI: 10.1111/bcp.13031

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  9. DRUG INTERACTIONS

    1. Top of page
    2. ISSUE INFORMATION
    3. ISSUE HIGHLIGHTS
    4. EDITORIAL
    5. SYSTEMATIC REVIEWS
    6. REVIEWS
    7. CLINICAL TRIALS
    8. PHARMACOKINETICS
    9. PHARMACOKINETIC DYNAMIC RELATIONSHIPS
    10. DRUG INTERACTIONS
    11. METHODS IN CLINICAL PHARMACOLOGY
    12. DRUG SAFETY
    13. DRUGS IN PREGNANCY AND LACTATION
    14. PHARMACOEPIDEMIOLOGY
    15. LETTER TO THE EDITOR
    1. Effect of esomeprazole, a proton pump inhibitor on the pharmacokinetics of sonidegib in healthy volunteers (pages 1022–1029)

      Jocelyn Zhou, Michelle Quinlan, Kelli Glenn, Hildegard Boss, Franck Picard, Henry Castro and Dalila Sellami

      Version of Record online: 13 JUL 2016 | DOI: 10.1111/bcp.13038

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  10. METHODS IN CLINICAL PHARMACOLOGY

    1. Top of page
    2. ISSUE INFORMATION
    3. ISSUE HIGHLIGHTS
    4. EDITORIAL
    5. SYSTEMATIC REVIEWS
    6. REVIEWS
    7. CLINICAL TRIALS
    8. PHARMACOKINETICS
    9. PHARMACOKINETIC DYNAMIC RELATIONSHIPS
    10. DRUG INTERACTIONS
    11. METHODS IN CLINICAL PHARMACOLOGY
    12. DRUG SAFETY
    13. DRUGS IN PREGNANCY AND LACTATION
    14. PHARMACOEPIDEMIOLOGY
    15. LETTER TO THE EDITOR
    1. Multicentre study for validation of the French addictovigilance network reports assessment tool (pages 1030–1039)

      Caroline Victorri-Vigneau, Jean Benoit Hardouin, Morgane Rousselet, Marie Gerardin, Marylène Guerlais, Morgane Guillou, Marie Bronnec, Véronique Sébille, Pascale Jolliet and the French Addictovigilance Network

      Version of Record online: 28 JUL 2016 | DOI: 10.1111/bcp.13044

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  11. DRUG SAFETY

    1. Top of page
    2. ISSUE INFORMATION
    3. ISSUE HIGHLIGHTS
    4. EDITORIAL
    5. SYSTEMATIC REVIEWS
    6. REVIEWS
    7. CLINICAL TRIALS
    8. PHARMACOKINETICS
    9. PHARMACOKINETIC DYNAMIC RELATIONSHIPS
    10. DRUG INTERACTIONS
    11. METHODS IN CLINICAL PHARMACOLOGY
    12. DRUG SAFETY
    13. DRUGS IN PREGNANCY AND LACTATION
    14. PHARMACOEPIDEMIOLOGY
    15. LETTER TO THE EDITOR
    1. More than skin deep. Ten year follow-up of delayed cutaneous adverse drug reactions (CADR) (pages 1040–1047)

      Linda Velta Graudins, Jenny Ly, Jason Trubiano and Ar Kar Aung

      Version of Record online: 18 JUL 2016 | DOI: 10.1111/bcp.13030

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    2. Performance of trigger tools in identifying adverse drug events in emergency department patients: a validation study (pages 1048–1057)

      Andrei Karpov, Catherine Parcero, Catherine P.Y. Mok, Chandima Panditha, Eugenia Yu, Linda Dempster and Corinne M. Hohl

      Version of Record online: 8 JUL 2016 | DOI: 10.1111/bcp.13032

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    3. Neonatal adverse drug reactions: an analysis of reports to the French pharmacovigilance database (pages 1058–1068)

      Florentia Kaguelidou, Frédérique Beau-Salinas, Annie Pierre Jonville-Bera and Evelyne Jacqz-Aigrain

      Version of Record online: 24 JUL 2016 | DOI: 10.1111/bcp.13034

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    4. Serious adverse drug events related to non-investigational drugs in academic clinical trials: another source of safety data for risk assessment? (pages 1069–1075)

      Pascale Olivier, Anne Gimbert, Anne-Laurène Colin, Francesco Salvo, Madlyne Becker, Valérie Marty, Jean-Louis Montastruc and Nadine Petitpain

      Version of Record online: 13 JUL 2016 | DOI: 10.1111/bcp.13035

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    5. Impact of age on long-term anticoagulation and how gender and monitoring setting affect it: implications for decision making and patient management (pages 1076–1083)

      Salah Abohelaika, Hilary Wynne, Peter Avery, Brian Robinson, Patrick Kesteven and Farhad Kamali

      Version of Record online: 24 JUL 2016 | DOI: 10.1111/bcp.13046

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  12. DRUGS IN PREGNANCY AND LACTATION

    1. Top of page
    2. ISSUE INFORMATION
    3. ISSUE HIGHLIGHTS
    4. EDITORIAL
    5. SYSTEMATIC REVIEWS
    6. REVIEWS
    7. CLINICAL TRIALS
    8. PHARMACOKINETICS
    9. PHARMACOKINETIC DYNAMIC RELATIONSHIPS
    10. DRUG INTERACTIONS
    11. METHODS IN CLINICAL PHARMACOLOGY
    12. DRUG SAFETY
    13. DRUGS IN PREGNANCY AND LACTATION
    14. PHARMACOEPIDEMIOLOGY
    15. LETTER TO THE EDITOR
    1. Population pharmacokinetics of 17α-hydroxyprogesterone caproate in singleton gestation (pages 1084–1093)

      Shringi Sharma, Steve Caritis, Gary Hankins, Menachem Miodovnik, Mary F. Hebert, Don Mattison and Raman Venkataramanan

      Version of Record online: 13 JUL 2016 | DOI: 10.1111/bcp.12990

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  13. PHARMACOEPIDEMIOLOGY

    1. Top of page
    2. ISSUE INFORMATION
    3. ISSUE HIGHLIGHTS
    4. EDITORIAL
    5. SYSTEMATIC REVIEWS
    6. REVIEWS
    7. CLINICAL TRIALS
    8. PHARMACOKINETICS
    9. PHARMACOKINETIC DYNAMIC RELATIONSHIPS
    10. DRUG INTERACTIONS
    11. METHODS IN CLINICAL PHARMACOLOGY
    12. DRUG SAFETY
    13. DRUGS IN PREGNANCY AND LACTATION
    14. PHARMACOEPIDEMIOLOGY
    15. LETTER TO THE EDITOR
    1. You have full text access to this OnlineOpen article
      EUROmediCAT signal detection: an evaluation of selected congenital anomaly-medication associations (pages 1094–1109)

      Joanne E. Given, Maria Loane, Johannes M. Luteijn, Joan K. Morris, Lolkje T.W. de Jong van den Berg, Ester Garne, Marie-Claude Addor, Ingeborg Barisic, Hermien de Walle, Miriam Gatt, Kari Klungsoyr, Babak Khoshnood, Anna Latos-Bielenska, Vera Nelen, Amanda J. Neville, Mary O'Mahony, Anna Pierini, David Tucker, Awi Wiesel and Helen Dolk

      Version of Record online: 7 JUL 2016 | DOI: 10.1111/bcp.12947

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    2. EUROmediCAT signal detection: a systematic method for identifying potential teratogenic medication (pages 1110–1122)

      Johannes M. Luteijn, Joan K. Morris, Ester Garne, Joanne Given, Lolkje de Jong-van den Berg, Marie-Claude Addor, Marian Bakker, Ingeborg Barisic, Miriam Gatt, Kari Klungsoyr, Anna Latos-Bielenska, Nathalie Lelong, Vera Nelen, Amanda Neville, Mary O'Mahony, Anna Pierini, David Tucker, Hermien de Walle, Awi Wiesel, Maria Loane and Helen Dolk

      Version of Record online: 4 AUG 2016 | DOI: 10.1111/bcp.13056

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    3. Initiation of strong prescription opioids in Australia: cohort characteristics and factors associated with the type of opioid initiated (pages 1123–1133)

      Natasa Gisev, Sallie-Anne Pearson, Bianca Blanch, Briony Larance, Timothy Dobbins, Sarah Larney and Louisa Degenhardt

      Version of Record online: 18 JUL 2016 | DOI: 10.1111/bcp.13026

  14. LETTER TO THE EDITOR

    1. Top of page
    2. ISSUE INFORMATION
    3. ISSUE HIGHLIGHTS
    4. EDITORIAL
    5. SYSTEMATIC REVIEWS
    6. REVIEWS
    7. CLINICAL TRIALS
    8. PHARMACOKINETICS
    9. PHARMACOKINETIC DYNAMIC RELATIONSHIPS
    10. DRUG INTERACTIONS
    11. METHODS IN CLINICAL PHARMACOLOGY
    12. DRUG SAFETY
    13. DRUGS IN PREGNANCY AND LACTATION
    14. PHARMACOEPIDEMIOLOGY
    15. LETTER TO THE EDITOR
    1. Ofatumumab-associated acute respiratory manifestations: clinical characteristics and treatment (pages 1146–1148)

      Alice Bonanni, Enrica Bertelli, Andrea Moscatelli, Elisabetta Lampugnani, Monica Bodria, Pietro Ravani and Gian Marco Ghiggeri

      Version of Record online: 28 JUN 2016 | DOI: 10.1111/bcp.13029

    2. You lookin' at me? (page 1149)

      Carl T. Bergstrom, Brian R. Wasik and Richard E. Lenski

      Version of Record online: 14 JUL 2016 | DOI: 10.1111/bcp.13036

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