Can Physical Exercise or Food Deprivation Cause Release of Fat-Stored Cannabinoids?
Article first published online: 22 APR 2014
© 2014 The Authors. Basic & Clinical Pharmacology & Toxicology published by John Wiley & Sons Ltd on behalf of Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Basic & Clinical Pharmacology & Toxicology
Volume 115, Issue 5, pages 467–471, November 2014
How to Cite
Westin, A. A., Mjønes, G., Burchardt, O., Fuskevåg, O. M. and Slørdal, L. (2014), Can Physical Exercise or Food Deprivation Cause Release of Fat-Stored Cannabinoids?. Basic & Clinical Pharmacology & Toxicology, 115: 467–471. doi: 10.1111/bcpt.12235
- Issue published online: 17 OCT 2014
- Article first published online: 22 APR 2014
- Accepted manuscript online: 27 MAR 2014 05:44AM EST
- Manuscript Accepted: 7 MAR 2014
- Manuscript Received: 21 JAN 2014
The aim of this study was to evaluate whether physical exercise or food deprivation may increase cannabinoid levels in serum or urine in abstinent chronic cannabis users. The study took place in a drug detoxification ward parallel to study participants receiving treatment. Six chronic, daily cannabis users (one female, five males, average age 30.0 years; BMI 20.8) were exposed to a 45-min. moderate-intensity workout and a 24-hr period of food deprivation. Serum samples were drawn prior to and after interventions and analysed for ∆9-tetrahydrocannabinol (THC) and 11-nor-9-carboxy-∆9-tetrahydrocannabinol (THCCOOH) by liquid chromatography–tandem mass spectrometry (LCMSMS), and all voided urine was tested for THCCOOH by LCMSMS and normalized to the creatinine levels, yielding ng/mg ratios. There were no major differences in the measured cannabinoid levels in serum or urine before and after physical exercise or food deprivation. We conclude that exercise and/or food deprivation are unlikely to cause sufficient cannabinoid concentration changes to hamper correct interpretations in drug testing programmes.