Cognitive decline in elderly bipolar disorder patients: a follow-up study
Article first published online: 21 SEP 2012
© 2012 John Wiley and Sons A/S
Volume 14, Issue 7, pages 749–755, November 2012
How to Cite
Schouws, S. N., Stek, M. L., Comijs, H. C., Dols, A. and Beekman, A. T. (2012), Cognitive decline in elderly bipolar disorder patients: a follow-up study. Bipolar Disorders, 14: 749–755. doi: 10.1111/bdi.12000
- Issue published online: 29 OCT 2012
- Article first published online: 21 SEP 2012
- Received 26 November 2010, revised and accepted for publication 03 July 2012
- bipolar disorder;
Schouws SNTM, Stek ML, Comijs HC, Dols A, Beekman ATF. Cognitive decline in elderly bipolar disorder patients: a follow-up study. Bipolar Disord 2012: 14: 749–755. © 2012 The Authors. Journal compilation © 2012 John Wiley & Sons A/S.
Objective: Older individuals with bipolar disorder may exhibit greater cognitive decline over time compared to mentally healthy elderly individuals. We aimed to investigate neurocognitive performance in bipolar disorder over a period of two years.
Methods: A comprehensive neuropsychological test battery was applied at baseline and two years later to 65 euthymic elderly outpatients with bipolar disorder (mean age = 68.35, range: 60–90 years) and to a demographically comparable sample of 42 healthy elderly controls. A general linear model was used to measure changes over time for the two groups. The impact of baseline illness characteristics on intra-individual change in neurocognitive performance within the bipolar group was studied by using logistic regression analysis.
Results: At baseline and at follow up, bipolar disorder patients performed worse on all neurocognitive measures compared to the healthy elderly group. However, there was no significant group-by-time interaction between the bipolar disorder patients and the comparison group.
Conclusions: Although older bipolar disorder patients have worse cognitive function than normal controls, they did not have greater cognitive decline over a period of two years.