Get access

Conflict monitoring and adaptation in individuals at familial risk for developing bipolar disorder

Authors

  • Luis R Patino,

    1. Division of Bipolar Disorders Research, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    2. Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente, Mexico City, Mexico
    Search for more papers by this author
  • Caleb M Adler,

    1. Division of Bipolar Disorders Research, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    2. Center for Imaging Research, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Search for more papers by this author
  • Neil P Mills,

    1. Division of Bipolar Disorders Research, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Search for more papers by this author
  • Stephen M Strakowski,

    1. Division of Bipolar Disorders Research, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    2. Center for Imaging Research, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Search for more papers by this author
  • David E Fleck,

    1. Division of Bipolar Disorders Research, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    2. Center for Imaging Research, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Search for more papers by this author
  • Jeffrey A Welge,

    1. Division of Bipolar Disorders Research, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Search for more papers by this author
  • Melissa P DelBello

    Corresponding author
    • Division of Bipolar Disorders Research, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Search for more papers by this author

Corresponding author:

Melissa P DelBello, M.D., M.S.

Department of Psychiatry and Behavioral Neuroscience

University of Cincinnati College of Medicine

260 Stetson Street, Suite 3200

Cincinnati, OH 45219-0516

USA

Fax: 513-558-3399

E-mail: delbelmp@ucmail.uc.edu

Abstract

Objective

To examine conflict monitoring and conflict-driven adaptation in individuals at familial risk for developing bipolar disorder.

Methods

We recruited 24 adolescents who had a parent with bipolar disorder and 23 adolescents with healthy parents. Participants completed an arrow version of the Eriksen Flanker Task that included trials with three levels of conflict: neutral, congruent, and incongruent flanks. Differences in performance were explored based upon the level of conflict in the current and previous trials.

Results

Individuals at risk for developing bipolar disorder performed more slowly than youth with healthy parents in all trials. Analyses evaluating sequential effects revealed that at-risk subjects responded more slowly than youth of healthy parents for all trial types when preceded by an incongruent trial, for incongruent trials preceded by congruent trials, and for neutral and congruent trials when preceded by neutral trials. In contrast to the comparison group, at-risk adolescents failed to display a response time advantage for incongruent trials preceded by an incongruent trial. When removing subjects with attention-deficit hyperactivity disorder (ADHD), differences between groups in response time fell below significant level, but a difference in sequence modulation remained significant. Subjects at risk for bipolar disorder also displayed greater intra-subject response time variability for incongruent and congruent trials compared with the comparison adolescents. No differences in response accuracy were observed between groups.

Conclusions

Adolescents at risk for developing bipolar disorder displayed specific deficits in cognitive flexibility, which might be useful as a potential marker related to the development of bipolar disorder.

Get access to the full text of this article

Ancillary