Neurocognitive features in subgroups of bipolar disorder
Article first published online: 25 MAR 2013
© 2013 John Wiley and Sons A/S. Published by Blackwell Publishing Ltd
Volume 15, Issue 3, pages 272–283, May 2013
How to Cite
Neurocognitive features in subgroups of bipolar disorder. Bipolar Disord 2013: 15:272–283. © 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd., , , , , .
- Issue published online: 3 MAY 2013
- Article first published online: 25 MAR 2013
- Manuscript Accepted: 12 JAN 2013
- Manuscript Received: 28 APR 2011
- the Research Council of Norway. Grant Numbers: #181831, 147787/320, 167153/V50
- the Regional Health Authority for South-Eastern Norway Health. Grant Numbers: #2004123, and #2006258
- age at onset;
- bipolar I disorder;
- bipolar II disorder;
- polarity of presenting episode;
To examine which subgroups of DSM-IV bipolar disorder (BD) [BD type I (BD-I) or BD type II (BD-II), and subgroups based on history of psychosis, presenting polarity, and age at onset] differentiate best regarding neurocognitive measures.
A total of 199 patients with BD were characterized by clinical and neurocognitive features. The distribution of subgroups in this sample was: BD-I, 64% and BD-II, 36%; 60% had a history of psychosis; 57% had depression as the presenting polarity; 61% had an early onset of BD, 25% had a mid onset, and 14% had a late onset. We used multivariate regression analyses to assess relationships between neurocognitive variables and clinical subgroups.
Both BD-I diagnosis and elevated presenting polarity were related to impairments in verbal memory, with elevated presenting polarity explaining more of the variance in this cognitive domain (22.5%). History of psychosis and BD-I diagnosis were both related to impairment in semantic fluency, with history of psychosis explaining more of the variance (11.6%).
Poor performance in verbal memory appears to be associated with an elevated presenting polarity, and poor performance in semantic fluency appears to be associated with a lifetime history of psychosis.