A quantitative review of neurocognition in euthymic late-life bipolar disorder
Article first published online: 7 MAY 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Volume 15, Issue 6, pages 633–644, September 2013
How to Cite
A quantitative review of neurocognition in euthymic late-life bipolar disorder. Bipolar Disord 2013: 15: 633–644. © 2013 John Wiley & Sons A/S., , .
- Issue published online: 3 SEP 2013
- Article first published online: 7 MAY 2013
- Manuscript Accepted: 13 JAN 2013
- Manuscript Received: 17 APR 2012
- bipolar disorder;
A sizeable body of work has consistently documented that a number of euthymic mixed-age bipolar disorder subjects exhibit prominent impairments in a variety of cognitive domains. By contrast, knowledge about neuropsychological functioning in elderly patients is scant, despite being necessary for the adequate treatment of this population and the understanding of illness evolution. The aim of this study was to combine findings from the available literature in order to examine the pattern and extent of cognitive deficits in euthymic late-life bipolar disorder subjects.
A literature search was conducted through the online databases PubMed, ScienceDirect, EBSCO, and Wiley-Blackwell, covering the period between January 1990 and April 2012. Effect sizes reflecting patient–control differences for 10 cognitive variables were extracted from selected investigations and combined by means of meta-analytical procedures.
No significant patient–control differences were found for global cognitive status as assessed with the Mini-Mental State Examination and the Clock Drawing Test. Significant overall effect sizes (Hedges' g) of between 0.61 and 0.88 were noted for sustained attention, digit span (forwards and backwards), delayed recall, serial learning, cognitive flexibility, and verbal fluency (phonemic and categorical).
The extent of cognitive dysfunction in euthymic late-life bipolar disorder subjects may be, on average, similar to that reported for remitted young adult patients. Larger effect sizes of impairment may be associated with late illness onset. Implications and future directions for research are proposed.