Amygdala and whole-brain activity to emotional faces distinguishes major depressive disorder and bipolar disorder
Article first published online: 1 AUG 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Volume 15, Issue 7, pages 741–752, November 2013
How to Cite
Amygdala and whole-brain activity to emotional faces distinguishes major depressive disorder and bipolar disorder. Bipolar Disord 2013: 15: 741–752. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd., , , , .
- Issue published online: 5 NOV 2013
- Article first published online: 1 AUG 2013
- Manuscript Accepted: 1 MAY 2013
- Manuscript Received: 21 MAY 2012
- National Institute of Mental Health. Grant Number: MH076971
- Michael and Morven Heller Research Fellowship. Grant Number: T32 MH018269
- bipolar disorder;
- brain imaging;
- emotion processing;
- major depressive disorder;
- whole brain
It can be clinically difficult to distinguish depressed individuals with bipolar disorder (BD) and major depressive disorder (MDD). To examine potential biomarkers of difference between the two disorders, the current study examined differences in the functioning of emotion-processing neural regions during a dynamic emotional faces task.
During functional magnetic resonance imaging, healthy control adults (HC) (n = 29) and depressed adults with MDD (n = 30) and BD (n = 22) performed an implicit emotional-faces task in which they identified a color label superimposed on neutral faces that dynamically morphed into one of four emotional faces (angry, fearful, sad, happy). We compared neural activation between the groups in an amygdala region-of-interest and at the whole-brain level.
Adults with MDD showed significantly greater activity than adults with BD in the left amygdala to the anger condition (p = 0.01). Results of whole-brain analyses (at p < 0.005, k ≥ 20) revealed that adults with BD showed greater activity to sad faces in temporoparietal regions, primarily in the left hemisphere, whereas individuals with MDD demonstrated greater activity than those with BD to displays of anger, fear, and happiness. Many of the observed BD–MDD differences represented abnormalities in functioning compared to HC.
We observed a dissociation between depressed adults with BD and MDD in the processing of emerging emotional faces. Those with BD showed greater activity during mood-congruent (i.e., sad) faces, whereas those with MDD showed greater activity for mood-incongruent (i.e., fear, anger, and happy) faces. Such findings may reflect markers of differences between BD and MDD depression in underlying pathophysiological processes.