A five-year follow-up study of neurocognitive functioning in bipolar disorder
Article first published online: 9 JUN 2014
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Volume 16, Issue 7, pages 722–731, November 2014
How to Cite
A five-year follow-up study of neurocognitive functioning in bipolar disorder. Bipolar Disord 2014: 16: 722–731. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd., , , , , , .
- Issue published online: 27 OCT 2014
- Article first published online: 9 JUN 2014
- Manuscript Accepted: 16 OCT 2013
- Manuscript Revised: 27 AUG 2013
- Manuscript Received: 9 MAR 2013
- bipolar disorder;
Cognitive dysfunction in bipolar disorder has been well-established in cross-sectional studies; however, there are few data regarding the longitudinal course of cognitive performance in bipolar disorder. The aim of this study was to examine the course of cognitive function in a sample of euthymic patients with bipolar disorder during a five-year follow-up period.
Eighty euthymic outpatients with a DSM-IV diagnosis of bipolar disorder and 40 healthy control comparison subjects were neuropsychologically assessed at baseline (T1) and then at follow-up of five years (T2). A neurocognitive battery including the main cognitive domains of speed of processing, working memory, attention, verbal memory, visual memory, and executive function was used to evaluate cognitive performance.
Repeated-measures multivariate analyses showed that progression of cognitive dysfunction in patients was not different to that of control subjects in any of the six cognitive domains examined. Only a measure from the verbal memory domain, delayed free recall, worsened more in patients with bipolar disorder. Additionally, it was found that clinical course during the follow-up period did not influence the course of cognitive dysfunction.
Cognitive dysfunction that is characteristic of bipolar disorder is persistent and stable over time. Only dysfunction in verbal recall was found to show a progressive course that cannot be explained by clinical or treatment variables.