Correction made after online publication on September 16:Results section has been updated.
Episodic memory impairments in bipolar disorder are associated with functional and structural brain changes
Article first published online: 27 AUG 2014
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Volume 16, Issue 8, pages 830–845, December 2014
How to Cite
Episodic memory impairments in bipolar disorder are associated with functional and structural brain changes. Bipolar Disord 2014: 16: 830–845. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd., , , , , , , .
- Issue published online: 4 DEC 2014
- Article first published online: 27 AUG 2014
- Manuscript Accepted: 20 DEC 2013
- Manuscript Received: 16 APR 2013
- German Research Council
- German Ministry for Education and Research. Grant Number: DLR 01GO0203
- Freunde der Universität
- bipolar disorder;
- fMRI ;
- non-verbal episodic memory;
We combined multimodal functional magnetic resonance imaging (fMRI) and structural magnetic resonance imaging to probe abnormalities in brain circuits underpinning episodic memory performance deficits in patients with bipolar disorder (BD).
We acquired whole-brain fMRI data in 21 patients with BD and a matched group of 20 healthy controls during a non-verbal episodic memory task, using abstract shapes. We also examined density of gray matter, using voxel-based morphometry (VBM), and integrity of connecting fiber tracts, using diffusion tensor imaging (DTI) and tract-based spatial statistics, for areas with significant activation differences.
Patients with BD remembered less well than controls which shapes they had seen and had lower activation levels during the encoding stage of the task in the anterior cingulate gyrus, the precuneus/cuneus bilaterally, and the left lingual gyrus, and higher activation levels during the retrieval stage in the left temporo-parietal junction. Patients with BD showed reduced gray matter volumes in the left anterior cingulate, the precuneus/cuneus bilaterally, and the left temporo-parietal region in comparison with controls. DTI revealed increased radial, axial, and mean diffusivity in the left superior longitudinal fascicle in patients with BD compared with controls.
Changes in task-related activation in frontal and parietal areas were associated with poorer episodic memory in patients with BD. Compared with data from single imaging modalities, integration of multimodal neuroimaging data enables the building of more complete neuropsychological models of mental disorders.