Corpus callosal morphology in youth with bipolar depression
Article first published online: 28 AUG 2014
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Volume 16, Issue 8, pages 889–893, December 2014
How to Cite
Corpus callosal morphology in youth with bipolar depression. Bipolar Disord 2014: 16: 889–893. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd., , , , .
- Issue published online: 4 DEC 2014
- Article first published online: 28 AUG 2014
- Manuscript Accepted: 15 APR 2014
- Manuscript Received: 15 OCT 2013
- Halifax Stanley Centre
- Cuthbertson and Fischer Chair in Paediatric Mental Health
- Alberta Children's Hospital Foundation
- Alberta Children's Hospital Research Institute for Child and Maternal Health
- Hotchkiss Brain Institute
- Mathison Centre for Mental Health Research & Education
- Alberta Health Services
- University of Calgary
- bipolar disorder;
- corpus callosum;
Recent evidence has demonstrated that corpus callosum maturation follows a similar developmental timeline to cognitive processes. Bipolar disorder (BD) has been associated with disruptions in error processing, response inhibition, and motor functioning, which are mediated by underlying white matter structures, including the corpus callosum. Disruptions in white matter integrity have been demonstrated in BD. However, it is unknown whether alterations in the developmental trajectory of the corpus callosum may contribute to cognitive impairments in the disorder.
We assessed the area of the corpus callosum and its subregions (the genu, rostral body, anterior and posterior bodies, isthmus, and splenium) in 14 treatment-naïve adolescents with BD (<21 years of age and in the depressed phase) and 18 healthy adolescent controls.
In comparison with healthy controls, participants with BD demonstrated a significantly reduced overall corpus callosum area. We also noted smaller areas in the anterior and posterior mid-body of the corpus callosum in adolescents with BD.
Our results suggest that commissural fibers of the corpus callosum are disrupted in early-onset BD. Specific decreases in the anterior and posterior mid-body callosal aspects may contribute to motor organization and inhibition deficits seen in BD. These findings are consistent with the involvement of inter-hemispheric tracts in early-onset BD, which may reflect an early deviation in white matter development.