Funding sources None declared.
CLINICAL AND LABORATORY INVESTIGATIONS
Clinical features and histological findings are potential indicators of activity in lesions of common vitiligo
Article first published online: 13 DEC 2012
© 2012 The Authors. BJD © 2012 British Association of Dermatologists
British Journal of Dermatology
Volume 168, Issue 2, pages 265–271, February 2013
How to Cite
Benzekri, L., Gauthier, Y., Hamada, S. and Hassam, B. (2013), Clinical features and histological findings are potential indicators of activity in lesions of common vitiligo. British Journal of Dermatology, 168: 265–271. doi: 10.1111/bjd.12034
Conflicts of interest None declared.
- Issue published online: 30 JAN 2013
- Article first published online: 13 DEC 2012
- Accepted manuscript online: 10 SEP 2012 10:40AM EST
- Accepted for publication 24 August 2012
Background Unstable vitiligo lesions are usually considered to be contraindications for surgical treatment. Unfortunately, in the majority of common vitiligo cases, neither accurate clinical signs nor routine blood tests are available to determine whether or not the disease is active.
Objectives To establish a direct correlation between the clinical aspect of vitiligo lesions and their activity.
Methods This was a prospective observational study that took place over 1 year. For each patient, a standardized evaluation included both a careful daylight and Wood’s lamp examination, pictures, biopsies performed at the marginal area and histological and immunohistological studies. A second examination to assess the activity of the lesions correctly was performed 1 year after inclusion in the study. Both the clinical changes and the histological features of the lesions in actively spreading vitiligo were compared with those in stable vitiligo.
Results This study included 50 patients. The lesions were classified as hypomelanotic with poorly defined borders (HPDB, 29 cases) or amelanotic with sharply demarcated borders (ASDB, 21 cases). One year after the biopsy, of the 48 patients still in the study, 20 had lesions that were considered to be stable and 28 had active lesions. Correlations were successfully obtained between clinical aspects, histological findings and vitiligo activity. The HPDB and ASDB lesions were correlated respectively with active and stable status (P < 0·001).
Conclusions A simple clinical examination including a Wood’s lamp examination may allow reliable and efficient evaluation of the stability of vitiligo lesions.