Funding sources Genotyping of the psoriasis samples was funded by the NIHR Manchester Biomedical Research Centre. J.B. and A.B. are funded by Arthritis Research UK, grant 17552. C.E.M.G. is an NIHR Senior Investigator and is funded in part by the Medical Research Council. R.B.W. is funded by an NIHR Clinical Senior Lectureship.
An investigation of rheumatoid arthritis loci in patients with early-onset psoriasis validates association of the REL gene
Article first published online: 27 FEB 2013
© 2012 The Authors. BJD © 2012 British Association of Dermatologists
British Journal of Dermatology
Volume 168, Issue 4, pages 864–866, April 2013
How to Cite
Ali, F.R., Barton, A., Smith, R.L.I., Bowes, J., Flynn, E., Mangino, M., Bataille, V., Foerster, J.P., Worthington, J., Griffiths, C.E.M. and Warren, R.B. (2013), An investigation of rheumatoid arthritis loci in patients with early-onset psoriasis validates association of the REL gene. British Journal of Dermatology, 168: 864–866. doi: 10.1111/bjd.12106
Conflicts of interest None declared.
- Issue published online: 25 MAR 2013
- Article first published online: 27 FEB 2013
- Accepted manuscript online: 27 OCT 2012 01:57AM EST
- Accepted for publication 14 October 2012
Background Phenotypically diverse autoimmune conditions share common genetic susceptibility loci and underlying molecular pathways.
Objectives By systematically searching for single nucleotide polymorphisms (SNPs) associated with another autoimmune disease, rheumatoid arthritis (RA), we aimed to elucidate novel genetic markers of psoriasis.
Methods We investigated 18 SNPs, previously confirmed as being associated with RA, in a U.K. cohort of 623 patients with early-onset psoriasis (presenting before age 40 years), comparing them with 2662 control subjects.
Results Our findings confirm the association of early-onset psoriasis with REL (rs13031237, P = 0·0027). The minor allele of REL had opposing effects upon susceptibility to disease in patients with psoriasis and RA.
Conclusion Similar exploration of additional autoimmune loci and fine mapping of such regions may provide further insight into the genetics and molecular pathophysiology of psoriasis.