An investigation of rheumatoid arthritis loci in patients with early-onset psoriasis validates association of the REL gene

Authors

  • F.R. Ali,

    1. The Dermatology Centre, Salford Royal NHS Foundation Trust,
    Search for more papers by this author
  • A. Barton,

    1. Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester Academic Health Science Centre, Manchester M6 8HD, U.K.
    2. NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester M13 9WL, U.K.
    Search for more papers by this author
  • R.L.I. Smith,

    1. Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester Academic Health Science Centre, Manchester M6 8HD, U.K.
    Search for more papers by this author
  • J. Bowes,

    1. Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester Academic Health Science Centre, Manchester M6 8HD, U.K.
    Search for more papers by this author
  • E. Flynn,

    1. Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester Academic Health Science Centre, Manchester M6 8HD, U.K.
    Search for more papers by this author
  • M. Mangino,

    1. Department of Twin Research and Genetic Epidemiology, King’s College London, St Thomas’ Hospital, London SE1 7EH, U.K.
    Search for more papers by this author
  • V. Bataille,

    1. Department of Twin Research and Genetic Epidemiology, King’s College London, St Thomas’ Hospital, London SE1 7EH, U.K.
    Search for more papers by this author
  • J.P. Foerster,

    1. Department of Dermatology and Division of Medical Sciences, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, U.K.
    Search for more papers by this author
  • J. Worthington,

    1. Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester Academic Health Science Centre, Manchester M6 8HD, U.K.
    2. NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester M13 9WL, U.K.
    Search for more papers by this author
  • C.E.M. Griffiths,

    1. The Dermatology Centre, Salford Royal NHS Foundation Trust,
    Search for more papers by this author
  • R.B. Warren

    1. The Dermatology Centre, Salford Royal NHS Foundation Trust,
    Search for more papers by this author

  • Funding sources
    Genotyping of the psoriasis samples was funded by the NIHR Manchester Biomedical Research Centre. J.B. and A.B. are funded by Arthritis Research UK, grant 17552. C.E.M.G. is an NIHR Senior Investigator and is funded in part by the Medical Research Council. R.B.W. is funded by an NIHR Clinical Senior Lectureship.

  • Conflicts of interest
    None declared.

Richard B. Warren.
E-mail: richard.warren@manchester.ac.uk

Summary

Background  Phenotypically diverse autoimmune conditions share common genetic susceptibility loci and underlying molecular pathways.

Objectives  By systematically searching for single nucleotide polymorphisms (SNPs) associated with another autoimmune disease, rheumatoid arthritis (RA), we aimed to elucidate novel genetic markers of psoriasis.

Methods  We investigated 18 SNPs, previously confirmed as being associated with RA, in a U.K. cohort of 623 patients with early-onset psoriasis (presenting before age 40 years), comparing them with 2662 control subjects.

Results  Our findings confirm the association of early-onset psoriasis with REL (rs13031237, = 0·0027). The minor allele of REL had opposing effects upon susceptibility to disease in patients with psoriasis and RA.

Conclusion  Similar exploration of additional autoimmune loci and fine mapping of such regions may provide further insight into the genetics and molecular pathophysiology of psoriasis.

Ancillary