Fig S1. Histological features oftrinitrochlorobenzene (TNCB)-induced atopic dermatitis (AD)-likedermatitis. Non-AD-like lesional (left ear; a and b) and AD-likelesional (right ear; c and d) skin tissues of TNCB-induced AD modelmice were cut into sections, and were stained with haematoxylin andeosin (a and c) or alcian blue and nuclear fast red (b and d).Original magnification, ×400.Bar = 100 μm.

Fig S2. Immunohistochemistry of CADM1 in theears of the atopic dermatitis (AD) mouse model. Sections of theAD-like lesions were immunostained with the CADM1 antibody (brown),and then stained with alcian blue and nuclear fast red. Boxes [band c in (a), and e–g in (d)] are enlarged. Open arrowheadsdepict CADM1-positive epidermal cells (c and e) and bulge cells(f). Closed arrowheads depict CADM1-positive nerve fibres (b, d, eand g); large arrowheads depict contacts between CADM1-positivenerve and epidermal cells (b, e and g). Arrows indicate mast cells(a–d). R, red cells; eRR, elongated rete ridge; BeHF, bulb ofelongated hair follicle. Original magnification; a and d,×400; b, c and e–g, ×1000.Bar = 50 μm.

bjd12108_sm_figs1.pdf8535KSupporting info item
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