Funding sources This study was supported by grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan.
Increased expression of cell adhesion molecule 1 by mast cells as a cause of enhanced nerve–mast cell interaction in a hapten-induced mouse model of atopic dermatitis
Version of Record online: 25 MAR 2013
© 2012 The Authors. BJD © 2012 British Association of Dermatologists
British Journal of Dermatology
Volume 168, Issue 4, pages 771–778, April 2013
How to Cite
Hagiyama, M., Inoue, T., Furuno, T., Iino, T., Itami, S., Nakanishi, M., Asada, H., Hosokawa, Y. and Ito, A. (2013), Increased expression of cell adhesion molecule 1 by mast cells as a cause of enhanced nerve–mast cell interaction in a hapten-induced mouse model of atopic dermatitis. British Journal of Dermatology, 168: 771–778. doi: 10.1111/bjd.12108
Conflicts of interest None declared.
- Issue online: 25 MAR 2013
- Version of Record online: 25 MAR 2013
- Accepted manuscript online: 27 OCT 2012 02:01AM EST
- Accepted for publication 14 October 2012
Fig S1. Histological features oftrinitrochlorobenzene (TNCB)-induced atopic dermatitis (AD)-likedermatitis. Non-AD-like lesional (left ear; a and b) and AD-likelesional (right ear; c and d) skin tissues of TNCB-induced AD modelmice were cut into sections, and were stained with haematoxylin andeosin (a and c) or alcian blue and nuclear fast red (b and d).Original magnification, ×400.Bar = 100 μm.
Fig S2. Immunohistochemistry of CADM1 in theears of the atopic dermatitis (AD) mouse model. Sections of theAD-like lesions were immunostained with the CADM1 antibody (brown),and then stained with alcian blue and nuclear fast red. Boxes [band c in (a), and e–g in (d)] are enlarged. Open arrowheadsdepict CADM1-positive epidermal cells (c and e) and bulge cells(f). Closed arrowheads depict CADM1-positive nerve fibres (b, d, eand g); large arrowheads depict contacts between CADM1-positivenerve and epidermal cells (b, e and g). Arrows indicate mast cells(a–d). R, red cells; eRR, elongated rete ridge; BeHF, bulb ofelongated hair follicle. Original magnification; a and d,×400; b, c and e–g, ×1000.Bar = 50 μm.
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