Funding sources This study was funded by the Innovation Oriented Research Program on Genomics (SenterNovem; IGE01014 and IGE5007), the Centre for Medical Systems Biology, the Netherlands Genomics Initiative/Netherlands Organization for Scientific Research (05040202 and 050-060-810), Unilever PLC and the EU-funded Network of Excellence Lifespan (FP6 036894). P.E.S. is supported by an unrestricted grant from the Netherlands Genomics Initiative (NCHA 050-060-810).
CLINICAL AND LABORATORY INVESTIGATIONS
Serum insulin-like growth factor 1 and facial ageing: high levels associate with reduced skin wrinkling in a cross-sectional study
Article first published online: 31 JAN 2013
© 2012 The Authors. BJD © 2012 British Association of Dermatologists
British Journal of Dermatology
Volume 168, Issue 3, pages 533–538, March 2013
How to Cite
Noordam, R., Gunn, D.A., Tomlin, C.C., Maier, A.B., Griffiths, T., Catt, S.D., Ogden, S., Slagboom, P.E., Westendorp, R.G.J., Griffiths, C.E.M., van Heemst, D., de Craen, A.J.M. and on behalf of the Leiden Longevity Study group (2013), Serum insulin-like growth factor 1 and facial ageing: high levels associate with reduced skin wrinkling in a cross-sectional study. British Journal of Dermatology, 168: 533–538. doi: 10.1111/bjd.12131
Conflicts of interest None declared.
- Issue published online: 28 FEB 2013
- Article first published online: 31 JAN 2013
- Accepted for publication 17 October 2012
Background Insulin-like growth factor (IGF)-1 is a growth factor that can influence fibroblast functioning, with effects including the inhibition of collagenases and the induction of collagen expression.
Objectives To assess whether serum IGF-1, IGF-binding protein (IGFBP)3 and the ratio between IGF-1 and IGFBP3, as a measure of IGF-1 bioavailability, are associated with facial ageing and skin wrinkling.
Methods From a random sample comprising 617 subjects from the Leiden Longevity Study, perceived age and skin wrinkling were assessed from facial photographs, and IGF-1 and IGFBP3 were measured in serum. The associations were assessed using linear regression models, adjusted for chronological age, sex, body mass index, smoking and sun exposure.
Results Across tertiles of the ratio of IGF-1 to IGFBP3, and after adjusting for all potential confounding factors, the mean perceived age decreased from 60·6 years in the lowest tertile to 59·5 years in the highest (Ptrend = 0·045). Similarly, the mean skin wrinkling grade decreased from 4·8 in the lowest tertile to 4·5 in the highest (Ptrend = 0·011). Adding skin wrinkling as a covariate in the analysis between IGF-1 and perceived age diminished this association.
Conclusions This study demonstrates that a higher ratio of IGF-1 to IGFBP3 associates with a lower perceived age, via its association with reduced skin wrinkling. Whether high IGF-1 levels actually delay the accumulation of skin wrinkling now needs investigating.