Funding sources None.
EPIDEMIOLOGY AND HEALTH SERVICES RESEARCH
Quality of life in Dutch women with lichen sclerosus
Article first published online: 7 MAR 2013
© 2012 The Authors. BJD © 2012 British Association of Dermatologists
British Journal of Dermatology
Volume 168, Issue 4, pages 787–793, April 2013
How to Cite
Lansdorp, C.A., van den Hondel, K.E., Korfage, I.J., van Gestel, M.J. and van der Meijden, W.I. (2013), Quality of life in Dutch women with lichen sclerosus. British Journal of Dermatology, 168: 787–793. doi: 10.1111/bjd.12137
Conflicts of interest None declared.
- Issue published online: 25 MAR 2013
- Article first published online: 7 MAR 2013
- Accepted manuscript online: 18 DEC 2012 11:31AM EST
- Accepted for publication 7 November 2012
Background Lichen sclerosus (LS) is a chronic inflammatory skin disease. Earlier studies have shown an impaired health-related quality of life (HRQoL), but more extensive research including generic questionnaires has not been reported.
Objectives To investigate, in a cross-sectional study, the HRQoL of a sample of Dutch women with LS; to compare the resulting HRQoL data with that available from other skin diseases and the general Dutch population; to explore factors that may influence the HRQoL.
Methods Female members of the Dutch LS Foundation and Support Group filled out three questionnaires electronically: the Skindex-29, the SF-12 and the EQ-5D visual analogue scale (VAS). We distinguished Skindex-29 scores into groups with ‘little’ (score 0–24), ‘mild’ (25–31), ‘moderate’ (32–43) and ‘severe’ (44–100) impact on HRQoL. We compared differences using the Mann–Whitney U-test and the Kruskal–Wallis test, and correlations using Spearman’s rank correlation coefficient.
Results A total of 262 women with LS were included. The average diagnostic delay was 4·9 (SD 7·1) years. Patients had a mean total Skindex-29 score of 38·4 (0–100, SD 17·2). Domain scores for symptoms, emotions and functioning were 46·8 (SD 19·0), 38·2 (SD 20·2) and 33·6 (SD 19·3), respectively. The SF-12 showed average PCS-12 (physical component) and MCS-12 (mental component) scores of 47·7 and 48·5, respectively. For the Dutch population these scores were 49·3 and 52·3. The mean EQ-5D VAS score was 74·1 (SD 15·4).
Conclusions There is a considerable delay in diagnosis for female Dutch patients with LS. The Skindex-29 domain scores showed a moderately impaired HRQoL. Women with LS reported a lower generic HRQoL than the average female Dutch population.