Funding sources This study was supported by an unrestricted educational grant from MoleMap New Zealand.
Effect of narrowband ultraviolet B phototherapy on melanocytic naevi
Article first published online: 27 FEB 2013
© 2012 The Authors. BJD © 2012 British Association of Dermatologists
British Journal of Dermatology
Volume 168, Issue 4, pages 815–819, April 2013
How to Cite
Lin, C.Y., Oakley, A., Rademaker, M., Hill, S. and Yung, A. (2013), Effect of narrowband ultraviolet B phototherapy on melanocytic naevi. British Journal of Dermatology, 168: 815–819. doi: 10.1111/bjd.12168
Conflicts of interest A.O. and M.R. are contracted to read MoleMaps for MoleMap New Zealand.
- Issue published online: 25 MAR 2013
- Article first published online: 27 FEB 2013
- Accepted for publication 18 October 2012
Background Melanocytic naevi have been observed to undergo morphological changes following exposure to narrowband ultraviolet (NB-UV)B radiation.
Objectives To analyse changes in naevi exposed to NB-UVB in a large cohort of patients.
Methods Subjects referred for phototherapy had macroscopic and dermoscopic images taken of prominent melanocytic naevi at the following time points: immediately prior to NB-UVB treatment, after 10 exposures, after 30 exposures or at the end of treatment if earlier, and 3 months after discontinuing treatment. Four dermatologists, by consensus, examined each naevus for specific clinical and dermoscopic features at each time point. The size (area) of each naevus was determined by plenimetry.
Results Complete sets of images were taken for 36 out of 51 patients. The most common global dermoscopic patterns in the 440 naevi examined were reticular (50%) and globular (32%). Following NB-UVB exposure, blurring or merging of lines was observed in 45% of reticular naevi. An increase in colour intensity and in the number of dots or globules was observed in 63% of globular naevi, and 167 naevi (40%) underwent a change in size. Of these, 91/167 (54%) decreased in size, with a median area reduction of 8% (0·9–42%); while 76/167 (46%) increased in size, with a median area increase of 9% (1–76%).
Conclusions Around half of naevi exposed to a course of NB-UVB treatment undergo size or morphological changes. Naevi that enlarged tended to revert to pretreatment size 3 months after discontinuation of phototherapy.