Funding sources The work was supported by the Italian Ministry of University and Research.
Association of KIF3A, but not OVOL1 and ACTL9, with atopic eczema in Italian patients
Article first published online: 25 APR 2013
© 2012 The Authors. BJD © 2012 British Association of Dermatologists
British Journal of Dermatology
Volume 168, Issue 5, pages 1106–1108, May 2013
How to Cite
Lepre, T., Cascella, R., Ragazzo, M., Galli, E., Novelli, G. and Giardina, E. (2013), Association of KIF3A, but not OVOL1 and ACTL9, with atopic eczema in Italian patients. British Journal of Dermatology, 168: 1106–1108. doi: 10.1111/bjd.12178
Conflicts of interest None declared.
- Issue published online: 25 APR 2013
- Article first published online: 25 APR 2013
- Accepted manuscript online: 19 DEC 2012 09:37PM EST
- Accepted for publication 2 December 2012
Background Atopic eczema (AE) (OMIM %603165) is the most common chronic inflammatory skin disease characterized by xerosis, pruritus, and erythematous lesions with increased transepidermal water loss. It’s a complex disease due to the interaction between environmental and genetics factors. To date, different loci have been related to the disease.
Objectives To verify the association, between AE and rs479844, rs2164983, and rs2897442, target for OVOLI (11q13), ACTL9 (19p13.2), and in KIF3A (5q31) genes in the Italian population. Recently, these SNPs have been validated as associated to the disease.
Methods A case-control study testing a cohort of 359 AE cases and 778 controls.
Results We confirmed the association between rs2897442 in KIF3A gene and the disease at both allele and genotype level (P-value: 4·8 × 10−4 and P-value: 6·3 × 10−4, respectively). The C allele of the SNP showed an Odds Ratio (OR) of 1·46 (95% CI 1·18–1·82), moreover the CC genotype achieved an OR of 2·77 (95% CI 1·66–4·61). We failed to reveal association between AE and the other two SNPs tested.
Conclusions Our study indicated KIF3A as a novel gene implicated in the development of AE in the Italian population.