Funding sources None.
Pulsed dye laser-resistant port-wine stains: mechanisms of resistance and implications for treatment
Article first published online: 25 APR 2013
© 2013 The Authors. BJD © 2013 British Association of Dermatologists
British Journal of Dermatology
Volume 168, Issue 5, pages 941–953, May 2013
How to Cite
Savas, J.A., Ledon, J.A., Franca, K., Chacon, A. and Nouri, K. (2013), Pulsed dye laser-resistant port-wine stains: mechanisms of resistance and implications for treatment. British Journal of Dermatology, 168: 941–953. doi: 10.1111/bjd.12204
Conflicts of interest None declared.
- Issue published online: 25 APR 2013
- Article first published online: 25 APR 2013
- Accepted manuscript online: 5 JAN 2013 08:44AM EST
- Accepted for publication 18 December 2012
Port-wine stains (PWS) are among the most common congenital vascular malformations. Unlike capillary haemangiomas, these lesions do not involute spontaneously but rather become progressively more disfiguring as the patient ages. While benign in nature, the cosmetic deformity and attendant psychological and emotional distress prompt the majority of those afflicted to seek treatment. The pulsed dye laser (PDL) has long been considered the treatment of choice for these vascular lesions; however, very few patients achieve total clearance with PDL therapy and a significant number of lesions fail to respond at all. In order to address these recalcitrant cases, the mechanisms that contribute to treatment resistance must be understood and novel laser and light therapies must be employed. This review will address what is currently known about lesion-specific characteristics of PDL-resistant PWS as well as discuss current and future treatment options.