Funding sources This work was supported by the Ministero della Salute, the Ministero dell’Istruzione, Università e Ricerca Scientifica [Programmi di Ricerca Scientifica di Rilevante Interesse Nazionale (PRIN)], and by the Association for Dermatological Research.
Ustekinumab does not increase body mass index in patients with chronic plaque psoriasis: a prospective cohort study
Article first published online: 25 APR 2013
© 2013 The Authors. BJD © 2013 British Association of Dermatologists
British Journal of Dermatology
Volume 168, Issue 5, pages 1124–1127, May 2013
How to Cite
Gisondi, P., Conti, A., Galdo, G., Piaserico, S., De Simone, C. and Girolomoni, G. (2013), Ustekinumab does not increase body mass index in patients with chronic plaque psoriasis: a prospective cohort study. British Journal of Dermatology, 168: 1124–1127. doi: 10.1111/bjd.12235
Conflicts of interest P.G. has received honoraria from lectures and/or board membership from Abbott, Janssen, Pfizer and Merck Sharp & Dohme. A.C. has received honoraria from Abbott and Pfizer. S.P. has received honoraria from Abbott, Janssen, Galderma, MSD, Novartis and Pfizer. C.DeS. has received honoraria from Abbott. G.G. has received honoraria from lectures, manuscript preparation, development of educational programmes and/or board membership from Abbott, Celgene, Janssen, Merck-Serono, Pfizer, Merck Sharp & Dohme and Novartis.
- Issue published online: 25 APR 2013
- Article first published online: 25 APR 2013
- Accepted manuscript online: 16 JAN 2013 04:28AM EST
- Accepted for publication 9 January 2013
Background Chronic plaque psoriasis is frequently associated with metabolic disorders including obesity. Antitumour necrosis factor α treatments can induce body-weight increase in patients with psoriasis. Information on the effect of ustekinumab on body weight is not available.
Objectives To investigate whether therapy with ustekinumab is associated with changes in body mass index (BMI) in patients with chronic plaque psoriasis.
Methods A prospective, multicentre study comparing the changes in BMI in two closed cohorts of patients with psoriasis during 7-month treatment with ustekinumab (n = 79) or infliximab (n = 83).
Results Patients treated for 7 months with infliximab showed a significant (P < 0·001) increase in mean BMI (2·1 ± 4·5%) and body weight (2·5 ± 3·3 kg) compared with patients treated with ustekinumab (0·1 ± 3·3%; 0·6 ± 1·1 kg). Some 45% of patients treated with infliximab had a BMI increase > 2%, compared with only 11% of those receiving ustekinumab (P = 0·01). In the multivariate analysis, all other clinical parameters predicted the BMI increase, except for the use of infliximab. At month 7, 96% of patients treated with infliximab and 82% of patients treated with ustekinumab achieved at least a 50% improvement from their baseline psoriasis area and severity index (PASI 50), and 69% of the infliximab group compared with 58% of the ustekinumab group achieved at least PASI 75. There was no difference in the proportion of PASI 50 and PASI 75 responders between the two groups.
Conclusions In contrast to infliximab, ustekinumab does not increase BMI in patients with chronic plaque psoriasis. This difference could be taken into account in the selection of biologics when treating patients with psoriasis.