Dermatomyositis is associated with an increased risk of cardiovascular and cerebrovascular events: a Taiwanese population-based longitudinal follow-up study

Authors

  • Y.-T. Lai,

    1. Department of Physical Medicine and Rehabilitation, Sijhih Cathay General Hospital, New Taipei, Taiwan
    2. Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan
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  • Y.-S. Dai,

    1. Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
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  • M.-F. Yen,

    1. School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
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  • L.-S. Chen,

    1. School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
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  • H.-H. Chen,

    1. Centre of Biostatistics Consultation, College of Public Health, National Taiwan University, Taipei, Taiwan
    2. Division of Biostatistics, Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
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  • R.G. Cooper,

    1. University of Manchester Rheumatic Diseases Centre, Salford Royal NHS Foundation Trust, Salford, U.K.
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  • S.-L. Pan

    1. Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
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  • Funding sources
    This work was supported by grants DOH93-TD-M-113-030, DOH94-TD-M-113-004 and DOH95-TD-M-113-002 from the Department of Health, Executive Yuan, Republic of China.

  • Conflicts of interest
    None declared.

Shin-Liang Pan.
E-mail: panslcb@gmail.com

Summary

Background  While the chronic inflammation related to autoimmune diseases is known to be associated with an increased cardiovascular risk, much less is known about cerebrovascular risks.

Objectives  The present population-based, age- and sex-matched follow-up study was undertaken to investigate the risks of acute myocardial infarction (AMI) and ischaemic stroke in patients with dermatomyositis (DMS).

Methods  In total 907 patients with DMS were enrolled and compared with a non-DMS control group consisting of 4535 age- and sex-matched, randomly sampled subjects without DMS. The AMI-free and ischaemic stroke-free survival curves were generated using the Kaplan–Meier method. Cox proportional hazard regression was used to estimate the DMS-associated risks of AMI and ischaemic stroke.

Results  During the 2-year follow-up period, 14 patients with DMS (1·5%) and 18 patients in the non-DMS control group (0·4%) suffered AMIs. The crude hazard ratio (HR) for suffering an AMI in patients with DMS compared with subjects in the non-DMS group was 3·96 [95% confidence interval (CI) 1·97–7·96, P = 0·0001], while the adjusted HR was 3·37 (95% CI 1·67–6·80, P = 0·0007), after taking into account demographic characteristics and cardiovascular comorbidities. During the same follow-up period, 46 patients (5·1%) and 133 subjects in the control group (2·9%) developed ischaemic strokes. The crude HR for developing an ischaemic stroke in patients with DMS compared with subjects in the non-DMS group was 1·78 (95% CI 1·27–2·49, P = 0·0007), and the adjusted HR was 1·67 (95% CI, 1·19–2·34, P = 0·0028).

Conclusions  These findings suggest that DMS is associated with an increased risk of cardiovascular and cerebrovascular events.

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