Funding sources National Natural Science Foundation of China (nos 8113032, 30972642, 30972528 and 81172749).
Clinical and Laboratory Investigations
Association between FOXP3 polymorphisms and vitiligo in a Han Chinese population
Article first published online: 30 AUG 2013
© 2013 The Authors BJD © 2013 British Association of Dermatologists
British Journal of Dermatology
Volume 169, Issue 3, pages 571–578, September 2013
How to Cite
Song, P., Wang, X.-W., Li, H.-X., Li, K., Liu, L., Wei, C., Jian, Z., Yi, X.-L., Li, Q., Wang, G., Li, C.-Y. and Gao, T.-W. (2013), Association between FOXP3 polymorphisms and vitiligo in a Han Chinese population. British Journal of Dermatology, 169: 571–578. doi: 10.1111/bjd.12377
P.S., X.-W.W. and H.-X.L. contributed equally to this work.
Conflicts of interest None declared.
- Issue published online: 30 AUG 2013
- Article first published online: 30 AUG 2013
- Accepted manuscript online: 12 APR 2013 09:41AM EST
- Manuscript Accepted: 9 APR 2013
- National Natural Science Foundation of China. Grant Numbers: 8113032, 30972642, 30972528, 81172749
Vitiligo is an autoimmune chronic depigmentation disorder caused by melanocyte loss. Previous studies found that CD4+CD25+ regulatory T-cell (Treg) dysfunction was involved in the pathogenesis of vitiligo and that gene polymorphisms in forkhead box P3 (FOXP3) – a master regulator of Treg development and function – were associated with susceptibility to some autoimmune disorders. Therefore, we hypothesized that functional polymorphisms of the FOXP3 gene might be associated with vitiligo via dysregulation of Treg cells.
To evaluate whether FOXP3 polymorphisms are associated with vitiligo risk.
Material and methods
In this hospital-based case–control study of 682 patients with vitiligo and 682 vitiligo-free age- and sex-matched controls, we genotyped three single nucleotide polymorphisms (SNPs) of the FOXP3 gene – rs2232365, rs3761548 and rs5902434 – by performing polymerase chain reaction with sequence-specific primers (PCR-SSP).
Significantly increased vitiligo risk was associated with the rs2232365 GG [odds ratio (OR) 1·68, 95% confidence interval (CI) 1·17–2·39, P = 0·004] and rs3761548 AA (OR 1·82, 95% CI 1·10–3·01, P = 0·033) genotypes compared with the rs2232365 AA and rs3761548 CC genotypes. On combined analysis of these three variant alleles, we found that individuals carrying 2–6 variant alleles had significantly increased vitiligo risk (OR 1·34, 95% CI 1·08–1·66). This risk was more pronounced in the following subgroups: age > 20 years, male sex, active vitiligo, nonsegmental vitiligo and other accompanying autoimmune diseases.
FOXP3 gene polymorphisms contributed to vitiligo risk in a Han Chinese population.