Funding sources Supported in part by the Italian Ministry of Health (RF-2010-2316524).
Clinical and Laboratory Investigations
Dermoscopy of basosquamous carcinoma
Version of Record online: 13 AUG 2013
© 2013 British Association of Dermatologists
British Journal of Dermatology
Volume 169, Issue 2, pages 358–364, August 2013
How to Cite
Giacomel, J., Lallas, A., Argenziano, G., Reggiani, C., Piana, S., Apalla, Z., Ferrara, G., Moscarella, E., Longo, C. and Zalaudek, I. (2013), Dermoscopy of basosquamous carcinoma. British Journal of Dermatology, 169: 358–364. doi: 10.1111/bjd.12394
Conflicts of interest None declared.
- Issue online: 13 AUG 2013
- Version of Record online: 13 AUG 2013
- Accepted manuscript online: 22 APR 2013 10:23AM EST
- Manuscript Accepted: 9 APR 2013
- Italian Ministry of Health. Grant Number: RF-2010-2316524
Basosquamous carcinoma (BSC) is a rare and potentially aggressive tumour, characterized by clinical and pathological features of both basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). It is reported to have a nonspecific clinical presentation, which makes naked-eye diagnosis a challenge.
To describe the dermoscopic patterns of BSC, which may facilitate early diagnosis and accurate management.
This was a retrospective evaluation of clinical and dermoscopic images of histopathologically proven BSC, collected from skin cancer centres in Australia (Perth), Greece (Thessaloniki) and Italy (Naples, Reggio Emilia).
Twenty-two tumours were included in the study. Our analysis revealed that the dermoscopic pattern of BSC comprises BCC-related criteria, as well as features that are known to characterize invasive SCC. The most frequently detected criteria were: unfocused (peripheral) arborizing vessels (73%), keratin masses (73%), white structureless areas (73%), superficial scale (68%), ulceration or blood crusts (68%), white structures (64%), blue-grey blotches (59%) and blood spots in keratin masses (55%). Notably, all but one of the tumours exhibited at least one BCC-related plus one SCC-related dermoscopic feature.
BSC appears to have overlapping dermoscopic features of BCC and invasive SCC, and detection of at least one dermoscopic criterion of both BCC and SCC should raise suspicion for the tumour. Appreciation of the dermoscopic patterns of BSC might assist in the timely and accurate diagnosis and subsequent optimal management of this unusual and potentially metastatic skin tumour.