Funding sources S.G. is supported by the March of Dimes, Basil O'Connor Starter Scholar Research Award no. 5-FY12 -55 and by the Talpiot Medical Leadership Program, Sheba Medical Center. J.B. is supported by NIH grants R01 HL 096384 and P01 AR48564.
Pathogenesis of infantile haemangioma
Article first published online: 8 JUL 2013
© 2013 British Association of Dermatologists
British Journal of Dermatology
Volume 169, Issue 1, pages 12–19, July 2013
How to Cite
Greenberger, S. and Bischoff, J. (2013), Pathogenesis of infantile haemangioma. British Journal of Dermatology, 169: 12–19. doi: 10.1111/bjd.12435
Conflicts of interest None declared.
S. Greenberger and J. Bischoff contributed equally to this work.
- Issue published online: 8 JUL 2013
- Article first published online: 8 JUL 2013
- Accepted manuscript online: 13 MAY 2013 09:16AM EST
- Manuscript Accepted: 9 MAY 2013
Haemangioma is a vascular tumour of infancy that is well known for its rapid growth during the first weeks to months of a child's life, followed by a spontaneous but slow involution. During the proliferative phase, the vessels are disorganized and composed of immature endothelial cells. When the tumour involutes, the vessels mature and enlarge but are reduced in number. Fat, fibroblasts and connective tissue replace the vascular tissue, with few, large, feeding and draining vessels evident. Both angiogenesis and vasculogenesis have been proposed as mechanisms contributing to the neovascularization in haemangioma tumours. In recent years, several of the ‘building blocks’, the cells comprising the haemangioma, have been isolated. Among them are haemangioma progenitor/stem cells, endothelial cells and pericytes. This review focuses on these cell types, and the molecular pathways within these cells that have been implicated in driving the pathogenesis of infantile haemangioma.