Funding sources None
Childhood-onset psoriasis: association with future cardiovascular and metabolic comorbidities
Article first published online: 10 OCT 2013
© 2013 The Authors BJD © 2013 British Association of Dermatologists
British Journal of Dermatology
Volume 169, Issue 4, pages 889–895, October 2013
How to Cite
Mahé, E., Maccari, F., Beauchet, A., Lahfa, M., Barthelemy, H., Reguiaï, Z., Beneton, N., Estève, E., Chaby, G., Ruer-Mulard, M., Steiner, H.-G., Pauwels, C., Avenel-Audran, M., Goujon-Henry, C., Descamps, V., Begon, E., Sigal, M.-L. and for the GEM Resopso (2013), Childhood-onset psoriasis: association with future cardiovascular and metabolic comorbidities. British Journal of Dermatology, 169: 889–895. doi: 10.1111/bjd.12441
Conflicts of interest Authors declare no conflict of interest in this study
- Issue published online: 10 OCT 2013
- Article first published online: 10 OCT 2013
- Accepted manuscript online: 12 AUG 2013 08:01AM EST
- Manuscript Accepted: 11 MAY 2013
Psoriasis is associated with higher prevalences of cardiovascular and metabolic comorbidities in adults but the relationship of age at onset and those prevalences is unknown.
To evaluate whether the childhood onset of psoriasis (COP) is correlated with the frequency of cardiovascular and metabolic comorbidities in adulthood.
This noninterventional, cross-sectional, multicentre study of adults with psoriasis was conducted in 29 dermatology centres in France. Data on sex, age at onset of psoriasis and its clinical characteristics, and cardiovascular risk factors, including weight, body mass index, waist circumference, dyslipidaemia, diabetes, hypertension, smoking, and personal/familial major adverse cardiovascular events (MACE) were systematically recorded.
Two thousand two hundred and one patients with psoriasis (male: 56%; mean age: 49 years; 25% with COP) were included consecutively in the study. Univariate analysis showed that COP was associated with lower frequencies of obesity, high waist circumference, diabetes, dyslipidaemia, hypertension, familial cardiovascular disease, MACE and metabolic syndrome, but more frequent active smoking. Multivariate analysis retained age as being associated with frequency of cardiovascular and metabolic comorbidities, and sex with smoking, but not age at the onset of psoriasis. Psoriasis severity was associated with higher frequencies of obesity and psoriatic arthritis.
Our results showed that COP does not seem to be an additional risk factor for higher frequencies of cardiovascular and metabolic comorbidities during adulthood.