Funding sources None.
Lower risk of atopic dermatitis among infants born extremely preterm compared with higher gestational age
Article first published online: 2 DEC 2013
© 2013 British Association of Dermatologists
British Journal of Dermatology
Volume 169, Issue 6, pages 1257–1264, December 2013
How to Cite
Barbarot, S., Gras-Leguen, C., Colas, H., Garrot, E., Darmaun, D., Larroque, B., Roze, J.C. and Ancel, P.Y. (2013), Lower risk of atopic dermatitis among infants born extremely preterm compared with higher gestational age. British Journal of Dermatology, 169: 1257–1264. doi: 10.1111/bjd.12581
Conflict of interest None declared.
- Issue published online: 2 DEC 2013
- Article first published online: 2 DEC 2013
- Accepted manuscript online: 12 AUG 2013 07:42AM EST
- Manuscript Accepted: 3 AUG 2013
It is not yet known whether the risk of developing atopic dermatitis (AD) is influenced by preterm birth. Moreover, AD risk has not been assessed in a large sample of extremely preterm infants (< 29 weeks’ gestation).
To determine whether the risk of AD is influenced by preterm birth.
We investigated the relationship between gestational age (GA) and AD using data from two independent population-based cohorts, including a total of 2329 preterm infants, of whom 479 were born extremely preterm.
There was a lower percentage of children with AD in the extremely preterm group compared with those born at a greater GA (Epipage cohort, 2-year outcome: 13·3% for 24–28 weeks, 17·6% for 29–32 weeks, 21·8% for 33–34 weeks, P = 0·02; LIFT cohort, 5-year outcome: 11% for 24–28 weeks, 21·5% for 29–32 weeks, 19·6% for 33–34 weeks, P = 0·11). After adjusting for confounding variables, a lower GA (< 29 weeks) was significantly associated with decreased risk of AD in the Epipage cohort [adjusted odds ratio (aOR) 0·57, 95% confidence interval (CI) 0·37–0·87; P = 0·009] and the LIFT cohort (aOR 0·41, 95% CI 0·18–0·90; P = 0·03).
Very low GA (< 29 weeks) was associated with a lower risk of AD compared with higher GA (29–34 weeks) and full-term birth.